PDBsum entry 1cf8

Catalytic antibody

PDB id: 1cf8

Contents

Protein chains

215 a.a. *

218 a.a. *

Ligands

HAZ

Metals

_CD ×2

Waters ×11

* Residue conservation analysis

PDB id:

1cf8

Name:

Catalytic antibody

Title:

Convergence of catalytic antibody and terpene cyclase mechanisms: polyene cyclization directed by carbocation-pi interactions

Structure:

Protein (catalytic antibody 19a4 (light chain)). Chain: l. Fragment: fab, variable region. Protein (catalytic antibody 19a4 (heavy chain)). Chain: h. Fragment: fab, variable region

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Strain: 129g1x+/boy. Cell_line: 129g1x+(mouse)/p3x63ag8.653 (myeloma). Cell_line: 129g1x+(mouse)/p3x63ag8.653 (myeloma)

Biol. unit:

Tetramer (from PQS)

Resolution:

2.70Å R-factor: 0.165 R-free: 0.257

Authors:

C.M.Paschall,J.Hasserodt,T.Jones,R.A.Lerner,K.D.Janda, D.W.Christianson

Key ref:

C.M.Paschall et al. (1999). Convergence of catalytic antibody and terpene cyclase mechanisms: polyene cyclization directed by carbocation-Pi interactions. Angew chem int ed engl, 38, 1743-1747.

Date:

24-Mar-99 Release date: 28-Jul-99

Protein chain

P01837  (IGKC_MOUSE) -  Immunoglobulin kappa constant from Mus musculus

Seq: 107 a.a.

Struc: 215 a.a.*

Protein chain

P01867  (IGG2B_MOUSE) -  Immunoglobulin heavy constant gamma 2B from Mus musculus

Seq: 404 a.a.

Struc: 218 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)