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PDBsum entry 1cda
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Int Immunol
5:233-238
(1993)
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PubMed id:
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A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors.
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M.C.Peitsch,
C.V.Jongeneel.
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ABSTRACT
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Based on the similarity in primary structure between the newly characterized
ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a
detailed 3-D structure for CD40L. We used the known structure of TNF alpha as a
template for the generation of the CD40L model. The soundness of the
model-building algorithms was verified by constructing a 3-D model of TNF beta
and comparing it to its crystallographically determined structure. The CD40L
sequence is entirely compatible with the 'jelly-roll' beta-strand structure
characteristic of the TNFs. Like the TNFs, CD40L is predicted to form a compact
trimer, although the interactions between monomers are distinct from those found
in the TNFs. The model predicts which regions of CD40L could interact with its
receptor(s) and which amino acids are essential for the maintenance of its
trimeric structure.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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PDB code:
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A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation.
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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