PDBsum entry 1c8m

Virus

PDB id: 1c8m

Contents

Protein chains

285 a.a. *

252 a.a. *

238 a.a. *

29 a.a. *

Ligands

W11

Metals

_ZN

Waters ×482

* Residue conservation analysis

PDB id:

1c8m

Name:

Virus

Title:

Refined crystal structure of human rhinovirus 16 complexed with vp63843 (pleconaril), an anti-picornaviral drug currently in clinical trials

Structure:

Human rhinovirus 16 coat protein. Chain: 1. Fragment: residues 569-853. Synonym: hrv16. Human rhinovirus 16 coat protein. Chain: 2. Fragment: residues 79-330. Synonym: hrv16. Human rhinovirus 16 coat protein.

Source:

Human rhinovirus 16. Organism_taxid: 31708. Strain: serotype 16. Strain: serotype 16

Resolution:

2.80Å R-factor: 0.219 R-free: 0.226

Authors:

S.Chakravarty,C.M.Bator,D.C.Pevear,G.D.Diana,M.G.Rossmann

Key ref:

S.Chakravarty et al. The refined structure of a picornavirus inhibitor currently in clinical trials, When complexed with human rhinovirus 16. To be published, .

Date:

26-May-00 Release date: 22-Nov-00

Protein chain

Q82122  (POLG_HRV16) -  Genome polyprotein from Human rhinovirus 16

Seq: 2153 a.a.

Struc: 285 a.a.

Protein chain

Q82122  (POLG_HRV16) -  Genome polyprotein from Human rhinovirus 16

Seq: 2153 a.a.

Struc: 252 a.a.

Protein chain

Q82122  (POLG_HRV16) -  Genome polyprotein from Human rhinovirus 16

Seq: 2153 a.a.

Struc: 238 a.a.

Protein chain

Q82122  (POLG_HRV16) -  Genome polyprotein from Human rhinovirus 16

Seq: 2153 a.a.

Struc: 29 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 2: Chains 1, 2, 3, 4: E.C.2.7.7.48 - RNA-directed Rna polymerase.
• Reaction: RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
• Enzyme class 3: Chains 1, 2, 3, 4: E.C.3.4.22.28 - picornain 3C.
• Reaction: Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
• Enzyme class 4: Chains 1, 2, 3, 4: E.C.3.4.22.29 - picornain 2A.
• Reaction: Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
• Enzyme class 5: Chains 1, 2, 3, 4: E.C.3.6.1.15 - nucleoside-triphosphate phosphatase.
• Reaction: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site