PDBsum entry 1bkf

Isomerase

PDB id: 1bkf

Contents

Protein chain

107 a.a. *

Ligands

FK5

Waters ×64

* Residue conservation analysis

PDB id:

1bkf

Name:

Isomerase

Title:

Fk506 binding protein fkbp mutant r42k/h87v complex with immunosuppressant fk506

Structure:

Fk506 binding protein. Chain: a. Synonym: fkbp. Engineered: yes. Mutation: yes. Other_details: complexed with immunosuppressant fk506

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Biol. unit:

Dimer (from PQS)

Resolution:

1.60Å R-factor: 0.187

Authors:

S.Itoh,M.T.Decenzo,D.J.Livingston,D.A.Pearlman,M.A.Navia

Key ref:

S.Itoh et al. (1995). Conformation of fk506 in X-Ray structures of its complexes with human recombinant fkbp12 mutants. Bioorg med chem lett, 5, 1983.

Date:

18-Oct-95 Release date: 01-Aug-96

Protein chain

P62942  (FKB1A_HUMAN) -  Peptidyl-prolyl cis-trans isomerase FKBP1A from Homo sapiens

Seq: 108 a.a.

Struc: 107 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site