|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
275 a.a.
|
|
|
|
|
|
|
|
|
|
|
99 a.a.
|
|
|
|
|
|
|
|
|
|
|
190 a.a.
|
|
|
|
|
|
|
|
|
|
|
242 a.a.
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Complex (mhc/viral peptide/receptor)
|
|
|
Title:
|
|
Complex between human t-cell receptor b7, viral peptide (tax) and mhc class i molecule hla-a 0201
|
|
Structure:
|
|
Hla-a 0201. Chain: a. Fragment: extracellular domains alpha 1, alpha 2, alpha 3. Synonym: hla a2 heavy chain. Engineered: yes. Beta-2 microglobulin. Chain: b. Engineered: yes. Tax peptide.
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Organ: plasma. Cellular_location: plasma membrane. Gene: hla-a 0201. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
Biol. unit:
|
|
Pentamer (from
)
|
|
Resolution:
|
|
|
2.50Å
|
R-factor:
|
0.238
|
R-free:
|
0.312
|
|
|
Authors:
|
|
Y.-H.Ding,K.J.Smith,D.N.Garboczi,U.Utz,W.E.Biddison,D.C.Wiley
|
Key ref:
|
|
Y.H.Ding
et al.
(1998).
Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids.
Immunity,
8,
403-411.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
12-May-98
|
Release date:
|
19-Aug-98
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P04439
(1A03_HUMAN) -
HLA class I histocompatibility antigen, A alpha chain from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
365 a.a.
275 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P61769
(B2MG_HUMAN) -
Beta-2-microglobulin from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
119 a.a.
99 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P01848
(TCA_HUMAN) -
T cell receptor alpha chain constant from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
140 a.a.
190 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P04437
(TVA29_HUMAN) -
T cell receptor alpha variable 29/delta variable 5 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
119 a.a.
190 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
DOI no:
|
Immunity
8:403-411
(1998)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids.
|
|
Y.H.Ding,
K.J.Smith,
D.N.Garboczi,
U.Utz,
W.E.Biddison,
D.C.Wiley.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
The three-dimensional structure of a human alphabeta T cell receptor (TCR), B7,
bound to the HLA-A2 molecule/HTLV-1 Tax peptide complex was determined by x-ray
crystallography. Although different from the A6 TCR, previously studied, in 16
of the 17 residues that contact HLA-A2/Tax, the B7 TCR binds in a similar
diagonal manner, only slightly tipped and rotated, relative to the A6 TCR. The
structure explains data from functional assays on the specificity differences
between the B7 and A6 TCRs for agonist, partial agonist, and null peptides. The
existence of a structurally similar diagonal binding mode for TCRs favors
mechanisms based on the formation of geometrically defined supramolecular
assemblies for initiating signaling.
|
|
|
|
|
|
| |
Selected figure(s)
|
|
|
|
| |
|
|
|
|
|
|
Figure 1.
Figure 1. Comparison of the Diagonal Binding Modes of the
Human B7 TCR and A6 TCR Bound to the HLA-A2/HTLV-1 Tax Peptide
Complex(A) Shown are the three variable or CDR loops of B7 TCR
Vα (red) and Vβ (yellow); A6 TCR (blue); HLA (dark blue); and
peptide (white). The variable loop 4 of Vα is omitted because
it makes no contacts in the B7 TCR complex.(B) The Vα and Vβ
domains of each TCR bound to HLA-A2 (colors as in [A]). The
α[1]α[2] domains of HLA-A2 from each TCR/MHC structure are
superimposed.(C) TCR/HLA-A2/Tax complexes are compared by
superimposing the HLA-A2 (blue) molecule. B7 TCR (red); A6 TCR
(green). B7–CDR2β contacts HLA-A2 (arrow); A6–CDR2β does
not.(D) Vα (blue)–Vβ (red) interface in B7 and A6 (light
colors). β chains of B7 and A6 are superimposed.Figure drawn
with RIBBONS ([6]).
|
|
Figure 3.
Figure 3. The Two TCR Surfaces That Contact the Same
MHC/Peptide Complex(A) The molecular surface of the B7 TCR with
a ball-and-stick model of the bound Tax peptide superimposed.
Surface color: red, negative electrostatic charge potential;
blue, positive.(B) The molecular surface of the A6 TCR with a
ball-and-stick model of the bound Tax peptide
superimposed.Figure drawn with GRASP ([28]).
|
|
|
|
|
|
| |
The above figures are
reprinted
by permission from Cell Press:
Immunity
(1998,
8,
403-411)
copyright 1998.
|
|
| |
Figures were
selected
by an automated process.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
J.M.Khan,
and
S.Ranganathan
(2011).
Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One.
|
| |
PLoS One,
6,
e17194.
|
|
|
|
|
|
|
S.Gras,
L.Kjer-Nielsen,
Z.Chen,
J.Rossjohn,
and
J.McCluskey
(2011).
The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection.
|
| |
Immunol Cell Biol,
89,
388-395.
|
|
|
|
|
|
|
G.I.van Boxel,
S.Holmes,
L.Fugger,
and
E.Y.Jones
(2010).
An alternative conformation of the T-cell receptor alpha constant region.
|
| |
J Mol Biol,
400,
828-837.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.J.Miles,
A.M.Bulek,
D.K.Cole,
E.Gostick,
A.J.Schauenburg,
G.Dolton,
V.Venturi,
M.P.Davenport,
M.P.Tan,
S.R.Burrows,
L.Wooldridge,
D.A.Price,
P.J.Rizkallah,
and
A.K.Sewell
(2010).
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.
|
| |
PLoS Pathog,
6,
e1001198.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.W.Wucherpfennig,
E.Gagnon,
M.J.Call,
E.S.Huseby,
and
M.E.Call
(2010).
Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.
|
| |
Cold Spring Harb Perspect Biol,
2,
a005140.
|
|
|
|
|
|
|
Y.Fujii,
T.Matsutani,
K.Kitaura,
S.Suzuki,
T.Itoh,
T.Takasaki,
R.Suzuki,
and
I.Kurane
(2010).
Comprehensive analysis and characterization of the TCR alpha chain sequences in the common marmoset.
|
| |
Immunogenetics,
62,
383-395.
|
|
|
|
|
|
|
Y.Godet,
J.Desfrançois,
V.Vignard,
D.Schadendorf,
A.Khammari,
B.Dreno,
F.Jotereau,
and
N.Labarrière
(2010).
Frequent occurrence of high affinity T cells against MELOE-1 makes this antigen an attractive target for melanoma immunotherapy.
|
| |
Eur J Immunol,
40,
1786-1794.
|
|
|
|
|
|
|
D.K.Cole,
F.Yuan,
P.J.Rizkallah,
J.J.Miles,
E.Gostick,
D.A.Price,
G.F.Gao,
B.K.Jakobsen,
and
A.K.Sewell
(2009).
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
|
| |
J Biol Chem,
284,
27281-27289.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
F.K.Insaidoo,
J.Zajicek,
and
B.M.Baker
(2009).
A general and efficient approach for NMR studies of peptide dynamics in class I MHC peptide binding grooves.
|
| |
Biochemistry,
48,
9708-9710.
|
|
|
|
|
|
|
K.H.Piepenbrink,
O.Y.Borbulevych,
R.F.Sommese,
J.Clemens,
K.M.Armstrong,
C.Desmond,
P.Do,
and
B.M.Baker
(2009).
Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner.
|
| |
Biochem J,
423,
353-361.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Rubtsova,
J.P.Scott-Browne,
F.Crawford,
S.Dai,
P.Marrack,
and
J.W.Kappler
(2009).
Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.
|
| |
Proc Natl Acad Sci U S A,
106,
7951-7956.
|
|
|
|
|
|
|
T.Beddoe,
Z.Chen,
C.S.Clements,
L.K.Ely,
S.R.Bushell,
J.P.Vivian,
L.Kjer-Nielsen,
S.S.Pang,
M.A.Dunstone,
Y.C.Liu,
W.A.Macdonald,
M.A.Perugini,
M.C.Wilce,
S.R.Burrows,
A.W.Purcell,
T.Tiganis,
S.P.Bottomley,
J.McCluskey,
and
J.Rossjohn
(2009).
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
|
| |
Immunity,
30,
777-788.
|
|
|
|
|
|
|
D.I.Godfrey,
J.Rossjohn,
and
J.McCluskey
(2008).
The fidelity, occasional promiscuity, and versatility of T cell receptor recognition.
|
| |
Immunity,
28,
304-314.
|
|
|
|
|
|
|
E.J.Collins,
and
D.S.Riddle
(2008).
TCR-MHC docking orientation: natural selection, or thymic selection?
|
| |
Immunol Res,
41,
267-294.
|
|
|
|
|
|
|
K.M.Armstrong,
K.H.Piepenbrink,
and
B.M.Baker
(2008).
Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.
|
| |
Biochem J,
415,
183-196.
|
|
|
|
|
|
|
L.G.Petrich de Marquesini,
A.K.Moustakas,
I.J.Thomas,
L.Wen,
G.K.Papadopoulos,
and
F.S.Wong
(2008).
Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands.
|
| |
Eur J Immunol,
38,
240-249.
|
|
|
|
|
|
|
P.Marrack,
J.P.Scott-Browne,
S.Dai,
L.Gapin,
and
J.W.Kappler
(2008).
Evolutionarily conserved amino acids that control TCR-MHC interaction.
|
| |
Annu Rev Immunol,
26,
171-203.
|
|
|
|
|
|
|
Z.Ma,
K.A.Sharp,
P.A.Janmey,
and
T.H.Finkel
(2008).
Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity.
|
| |
PLoS Biol,
6,
e43.
|
|
|
|
|
|
|
C.Mazza,
and
B.Malissen
(2007).
What guides MHC-restricted TCR recognition?
|
| |
Semin Immunol,
19,
225-235.
|
|
|
|
|
|
|
C.Mazza,
N.Auphan-Anezin,
C.Gregoire,
A.Guimezanes,
C.Kellenberger,
A.Roussel,
A.Kearney,
P.A.van der Merwe,
A.M.Schmitt-Verhulst,
and
B.Malissen
(2007).
How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?
|
| |
EMBO J,
26,
1972-1983.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.Feng,
C.J.Bond,
L.K.Ely,
J.Maynard,
and
K.C.Garcia
(2007).
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
|
| |
Nat Immunol,
8,
975-983.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
F.E.Tynan,
H.H.Reid,
L.Kjer-Nielsen,
J.J.Miles,
M.C.Wilce,
L.Kostenko,
N.A.Borg,
N.A.Williamson,
T.Beddoe,
A.W.Purcell,
S.R.Burrows,
J.McCluskey,
and
J.Rossjohn
(2007).
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule.
|
| |
Nat Immunol,
8,
268-276.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
O.Y.Borbulevych,
F.K.Insaidoo,
T.K.Baxter,
D.J.Powell,
L.A.Johnson,
N.P.Restifo,
and
B.M.Baker
(2007).
Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition.
|
| |
J Mol Biol,
372,
1123-1136.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
P.J.Miller,
Y.Pazy,
B.Conti,
D.Riddle,
E.Appella,
and
E.J.Collins
(2007).
Single MHC mutation eliminates enthalpy associated with T cell receptor binding.
|
| |
J Mol Biol,
373,
315-327.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.J.Bordner,
and
R.Abagyan
(2006).
Ab initio prediction of peptide-MHC binding geometry for diverse class I MHC allotypes.
|
| |
Proteins,
63,
512-526.
|
|
|
|
|
|
|
A.K.Iversen,
G.Stewart-Jones,
G.H.Learn,
N.Christie,
C.Sylvester-Hviid,
A.E.Armitage,
R.Kaul,
T.Beattie,
J.K.Lee,
Y.Li,
P.Chotiyarnwong,
T.Dong,
X.Xu,
M.A.Luscher,
K.MacDonald,
H.Ullum,
B.Klarlund-Pedersen,
P.Skinhøj,
L.Fugger,
S.Buus,
J.I.Mullins,
E.Y.Jones,
P.A.van der Merwe,
and
A.J.McMichael
(2006).
Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope.
|
| |
Nat Immunol,
7,
179-189.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.Thilo,
P.Berglund,
S.E.Applequist,
J.W.Yewdell,
H.G.Ljunggren,
and
A.Achour
(2006).
Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules: prominent role of a single arginine residue in human leukocyte antigen-A2.
|
| |
J Biol Chem,
281,
8950-8957.
|
|
|
|
|
|
|
E.Martinez-Hackert,
N.Anikeeva,
S.A.Kalams,
B.D.Walker,
W.A.Hendrickson,
and
Y.Sykulev
(2006).
Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes.
|
| |
J Biol Chem,
281,
20205-20212.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
L.C.Sullivan,
H.L.Hoare,
J.McCluskey,
J.Rossjohn,
and
A.G.Brooks
(2006).
A structural perspective on MHC class Ib molecules in adaptive immunity.
|
| |
Trends Immunol,
27,
413-420.
|
|
|
|
|
|
|
L.K.Ely,
T.Beddoe,
C.S.Clements,
J.M.Matthews,
A.W.Purcell,
L.Kjer-Nielsen,
J.McCluskey,
and
J.Rossjohn
(2006).
Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.
|
| |
Proc Natl Acad Sci U S A,
103,
6641-6646.
|
|
|
|
|
|
|
M.G.Rudolph,
R.L.Stanfield,
and
I.A.Wilson
(2006).
How TCRs bind MHCs, peptides, and coreceptors.
|
| |
Annu Rev Immunol,
24,
419-466.
|
|
|
|
|
|
|
S.M.Dunn,
P.J.Rizkallah,
E.Baston,
T.Mahon,
B.Cameron,
R.Moysey,
F.Gao,
M.Sami,
J.Boulter,
Y.Li,
and
B.K.Jakobsen
(2006).
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
|
| |
Protein Sci,
15,
710-721.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.R.Burrows,
J.Rossjohn,
and
J.McCluskey
(2006).
Have we cut ourselves too short in mapping CTL epitopes?
|
| |
Trends Immunol,
27,
11-16.
|
|
|
|
|
|
|
D.M.Zajonc,
M.D.Crispin,
T.A.Bowden,
D.C.Young,
T.Y.Cheng,
J.Hu,
C.E.Costello,
P.M.Rudd,
R.A.Dwek,
M.J.Miller,
M.B.Brenner,
D.B.Moody,
and
I.A.Wilson
(2005).
Molecular mechanism of lipopeptide presentation by CD1a.
|
| |
Immunity,
22,
209-219.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
F.E.Tynan,
S.R.Burrows,
A.M.Buckle,
C.S.Clements,
N.A.Borg,
J.J.Miles,
T.Beddoe,
J.C.Whisstock,
M.C.Wilce,
S.L.Silins,
J.M.Burrows,
L.Kjer-Nielsen,
L.Kostenko,
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
(2005).
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide.
|
| |
Nat Immunol,
6,
1114-1122.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.Li,
S.Van Vranken,
Y.Zhao,
Z.Li,
Y.Guo,
L.Eisele,
and
Y.Li
(2005).
Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.
|
| |
Protein Sci,
14,
3025-3038.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.L.Brzezinski,
R.Deka,
A.G.Menon,
D.N.Glass,
and
E.Choi
(2005).
Variability in TRBV haplotype frequency and composition in Caucasian, African American, Western African and Chinese populations.
|
| |
Int J Immunogenet,
32,
413-420.
|
|
|
|
|
|
|
J.Maynard,
K.Petersson,
D.H.Wilson,
E.J.Adams,
S.E.Blondelle,
M.J.Boulanger,
D.B.Wilson,
and
K.C.Garcia
(2005).
Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.
|
| |
Immunity,
22,
81-92.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Hülsmeyer,
P.Chames,
R.C.Hillig,
R.L.Stanfield,
G.Held,
P.G.Coulie,
C.Alings,
G.Wille,
W.Saenger,
B.Uchanska-Ziegler,
H.R.Hoogenboom,
and
A.Ziegler
(2005).
A major histocompatibility complex-peptide-restricted antibody and t cell receptor molecules recognize their target by distinct binding modes: crystal structure of human leukocyte antigen (HLA)-A1-MAGE-A1 in complex with FAB-HYB3.
|
| |
J Biol Chem,
280,
2972-2980.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Hahn,
M.J.Nicholson,
J.Pyrdol,
and
K.W.Wucherpfennig
(2005).
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor.
|
| |
Nat Immunol,
6,
490-496.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.Garbelli,
S.Mantovani,
B.Palermo,
and
C.Giachino
(2005).
Melanocyte-specific, cytotoxic T cell responses in vitiligo: the effective variant of melanoma immunity?
|
| |
Pigment Cell Res,
18,
234-242.
|
|
|
|
|
|
|
S.Huang,
S.Gilfillan,
M.Cella,
M.J.Miley,
O.Lantz,
L.Lybarger,
D.H.Fremont,
and
T.H.Hansen
(2005).
Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.
|
| |
J Biol Chem,
280,
21183-21193.
|
|
|
|
|
|
|
J.E.Gumperz
(2004).
Antigen specificity of semi-invariant CD1d-restricted T cell receptors: the best of both worlds?
|
| |
Immunol Cell Biol,
82,
285-294.
|
|
|
|
|
|
|
J.K.Lee,
G.Stewart-Jones,
T.Dong,
K.Harlos,
K.Di Gleria,
L.Dorrell,
D.C.Douek,
P.A.van der Merwe,
E.Y.Jones,
and
A.J.McMichael
(2004).
T cell cross-reactivity and conformational changes during TCR engagement.
|
| |
J Exp Med,
200,
1455-1466.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.K.Baxter,
S.J.Gagnon,
R.L.Davis-Harrison,
J.C.Beck,
A.K.Binz,
R.V.Turner,
W.E.Biddison,
and
B.M.Baker
(2004).
Strategic mutations in the class I major histocompatibility complex HLA-A2 independently affect both peptide binding and T cell receptor recognition.
|
| |
J Biol Chem,
279,
29175-29184.
|
|
|
|
|
|
|
V.Apostolopoulos,
and
E.Lazoura
(2004).
Noncanonical peptides in complex with MHC class I.
|
| |
Expert Rev Vaccines,
3,
151-162.
|
|
|
|
|
|
|
A.Hamrouni,
A.Aublin,
P.Guillaume,
and
J.L.Maryanski
(2003).
T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires.
|
| |
J Exp Med,
197,
601-614.
|
|
|
|
|
|
|
D.Housset,
and
B.Malissen
(2003).
What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity?
|
| |
Trends Immunol,
24,
429-437.
|
|
|
|
|
|
|
H.Robertson,
and
J.A.Kirby
(2003).
Post-transplant renal tubulitis: the recruitment, differentiation and persistence of intra-epithelial T cells.
|
| |
Am J Transplant,
3,
3.
|
|
|
|
|
|
|
J.Buslepp,
H.Wang,
W.E.Biddison,
E.Appella,
and
E.J.Collins
(2003).
A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection.
|
| |
Immunity,
19,
595-606.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
L.Kjer-Nielsen,
C.S.Clements,
A.W.Purcell,
A.G.Brooks,
J.C.Whisstock,
S.R.Burrows,
J.McCluskey,
and
J.Rossjohn
(2003).
A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity.
|
| |
Immunity,
18,
53-64.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
P.A.van der Merwe,
and
S.J.Davis
(2003).
Molecular interactions mediating T cell antigen recognition.
|
| |
Annu Rev Immunol,
21,
659-684.
|
|
|
|
|
|
|
R.H.McMahan,
L.Watson,
R.Meza-Romero,
G.G.Burrows,
D.N.Bourdette,
and
A.C.Buenafe
(2003).
Production, characterization, and immunogenicity of a soluble rat single chain T cell receptor specific for an encephalitogenic peptide.
|
| |
J Biol Chem,
278,
30961-30970.
|
|
|
|
|
|
|
S.Radaev,
and
P.D.Sun
(2003).
Structure and function of natural killer cell surface receptors.
|
| |
Annu Rev Biophys Biomol Struct,
32,
93.
|
|
|
|
|
|
|
Z.Wang,
and
J.Moult
(2003).
Three-dimensional structural location and molecular functional effects of missense SNPs in the T cell receptor Vbeta domain.
|
| |
Proteins,
53,
748-757.
|
|
|
|
|
|
|
A.Achour,
J.Michaëlsson,
R.A.Harris,
J.Odeberg,
P.Grufman,
J.K.Sandberg,
V.Levitsky,
K.Kärre,
T.Sandalova,
and
G.Schneider
(2002).
A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses.
|
| |
Immunity,
17,
757-768.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.S.Clements,
L.Kjer-Nielsen,
W.A.MacDonald,
A.G.Brooks,
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
(2002).
The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.
|
| |
Acta Crystallogr D Biol Crystallogr,
58,
2131-2134.
|
|
|
|
|
|
|
J.G.Luz,
M.Huang,
K.C.Garcia,
M.G.Rudolph,
V.Apostolopoulos,
L.Teyton,
and
I.A.Wilson
(2002).
Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.
|
| |
J Exp Med,
195,
1175-1186.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.Hennecke,
and
D.C.Wiley
(2002).
Structure of a complex of the human alpha/beta T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity.
|
| |
J Exp Med,
195,
571-581.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Hernandez,
F.Garcia-Pons,
Y.C.Lone,
H.Firat,
J.D.Schmidt,
P.Langlade-Demoyen,
and
M.Zanetti
(2002).
Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells.
|
| |
Proc Natl Acad Sci U S A,
99,
12275-12280.
|
|
|
|
|
|
|
K.Natarajan,
N.Dimasi,
J.Wang,
R.A.Mariuzza,
and
D.H.Margulies
(2002).
Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.
|
| |
Annu Rev Immunol,
20,
853-885.
|
|
|
|
|
|
|
L.Kjer-Nielsen,
C.S.Clements,
A.G.Brooks,
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
(2002).
The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.
|
| |
Structure,
10,
1521-1532.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.G.Rudolph,
and
I.A.Wilson
(2002).
The specificity of TCR/pMHC interaction.
|
| |
Curr Opin Immunol,
14,
52-65.
|
|
|
|
|
|
|
M.G.Rudolph,
J.G.Luz,
and
I.A.Wilson
(2002).
Structural and thermodynamic correlates of T cell signaling.
|
| |
Annu Rev Biophys Biomol Struct,
31,
121-149.
|
|
|
|
|
|
|
P.E.Adrian,
G.Rajaseger,
V.S.Mathura,
M.K.Sakharkar,
and
P.Kangueane
(2002).
Types of inter-atomic interactions at the MHC-peptide interface: identifying commonality from accumulated data.
|
| |
BMC Struct Biol,
2,
2.
|
|
|
|
|
|
|
R.König
(2002).
Interactions between MHC molecules and co-receptors of the TCR.
|
| |
Curr Opin Immunol,
14,
75-83.
|
|
|
|
|
|
|
T.Sasada,
M.Touma,
H.C.Chang,
L.K.Clayton,
J.H.Wang,
and
E.L.Reinherz
(2002).
Involvement of the TCR Cbeta FG loop in thymic selection and T cell function.
|
| |
J Exp Med,
195,
1419-1431.
|
|
|
|
|
|
|
T.Yokosuka,
K.Takase,
M.Suzuki,
Y.Nakagawa,
S.Taki,
H.Takahashi,
T.Fujisawa,
H.Arase,
and
T.Saito
(2002).
Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system.
|
| |
J Exp Med,
195,
991.
|
|
|
|
|
|
|
A.Qadri,
and
E.S.Ward
(2001).
Activation of a T cell hybridoma by an alloligand results in differential effects on IL-2 secretion and activation-induced cell death.
|
| |
Eur J Immunol,
31,
3825-3832.
|
|
|
|
|
|
|
A.Quesnel,
A.Zerbib,
F.Connan,
J.G.Guillet,
J.P.Briand,
and
J.Choppin
(2001).
Synthesis and antigenic properties of reduced peptide bond analogues of an immunodominant epitope of the melanoma MART-1 protein.
|
| |
J Pept Sci,
7,
157-165.
|
|
|
|
|
|
|
B.K.Cho,
K.C.Lian,
P.Lee,
A.Brunmark,
C.McKinley,
J.Chen,
D.M.Kranz,
and
H.N.Eisen
(2001).
Differences in antigen recognition and cytolytic activity of CD8(+) and CD8(-) T cells that express the same antigen-specific receptor.
|
| |
Proc Natl Acad Sci U S A,
98,
1723-1727.
|
|
|
|
|
|
|
B.M.Baker,
R.V.Turner,
S.J.Gagnon,
D.C.Wiley,
and
W.E.Biddison
(2001).
Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors.
|
| |
J Exp Med,
193,
551-562.
|
|
|
|
|
|
|
J.Buslepp,
R.Zhao,
D.Donnini,
D.Loftus,
M.Saad,
E.Appella,
and
E.J.Collins
(2001).
T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface.
|
| |
J Biol Chem,
276,
47320-47328.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.Hennecke,
and
D.C.Wiley
(2001).
T cell receptor-MHC interactions up close.
|
| |
Cell,
104,
1-4.
|
|
|
|
|
|
|
K.D.Bourcier,
D.G.Lim,
Y.H.Ding,
K.J.Smith,
K.Wucherpfennig,
and
D.A.Hafler
(2001).
Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure.
|
| |
J Virol,
75,
9836-9843.
|
|
|
|
|
|
|
K.W.Wucherpfennig
(2001).
Structural basis of molecular mimicry.
|
| |
J Autoimmun,
16,
293-302.
|
|
|
|
|
|
|
M.G.Rudolph,
J.A.Speir,
A.Brunmark,
N.Mattsson,
M.R.Jackson,
P.A.Peterson,
L.Teyton,
and
I.A.Wilson
(2001).
The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity.
|
| |
Immunity,
14,
231-242.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.Regner
(2001).
Cross-reactivity in T-cell antigen recognition.
|
| |
Immunol Cell Biol,
79,
91.
|
|
|
|
|
|
|
M.Saito,
G.P.Taylor,
A.Saito,
Y.Furukawa,
K.Usuku,
J.N.Weber,
M.Osame,
and
C.R.Bangham
(2001).
In vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes.
|
| |
J Virol,
75,
1065-1071.
|
|
|
|
|
|
|
P.M.Rudd,
T.Elliott,
P.Cresswell,
I.A.Wilson,
and
R.A.Dwek
(2001).
Glycosylation and the immune system.
|
| |
Science,
291,
2370-2376.
|
|
|
|
|
|
|
S.Radaev,
B.Rostro,
A.G.Brooks,
M.Colonna,
and
P.D.Sun
(2001).
Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.
|
| |
Immunity,
15,
1039-1049.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Z.J.Sun,
K.S.Kim,
G.Wagner,
and
E.L.Reinherz
(2001).
Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.
|
| |
Cell,
105,
913-923.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
B.M.Baker,
S.J.Gagnon,
W.E.Biddison,
and
D.C.Wiley
(2000).
Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.
|
| |
Immunity,
13,
475-484.
|
|
|
|
|
|
|
C.R.Bangham
(2000).
The immune response to HTLV-I.
|
| |
Curr Opin Immunol,
12,
397-402.
|
|
|
|
|
|
|
C.T.Morita,
R.A.Mariuzza,
and
M.B.Brenner
(2000).
Antigen recognition by human gamma delta T cells: pattern recognition by the adaptive immune system.
|
| |
Springer Semin Immunopathol,
22,
191-217.
|
|
|
|
|
|
|
D.Fleury,
R.S.Daniels,
J.J.Skehel,
M.Knossow,
and
T.Bizebard
(2000).
Structural evidence for recognition of a single epitope by two distinct antibodies.
|
| |
Proteins,
40,
572-578.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
F.A.Saul,
P.Rovira,
G.Boulot,
E.J.Damme,
W.J.Peumans,
P.Truffa-Bachi,
and
G.A.Bentley
(2000).
Crystal structure of Urtica dioica agglutinin, a superantigen presented by MHC molecules of class I and class II.
|
| |
Structure,
8,
593-603.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
H.W.Kessels,
M.D.van Den Boom,
H.Spits,
E.Hooijberg,
and
T.N.Schumacher
(2000).
Changing T cell specificity by retroviral T cell receptor display.
|
| |
Proc Natl Acad Sci U S A,
97,
14578-14583.
|
|
|
|
|
|
|
J.Hennecke,
A.Carfi,
and
D.C.Wiley
(2000).
Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1.
|
| |
EMBO J,
19,
5611-5624.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.L.Xu,
and
M.M.Davis
(2000).
Diversity in the CDR3 region of V(H) is sufficient for most antibody specificities.
|
| |
Immunity,
13,
37-45.
|
|
|
|
|
|
|
J.Wang,
and
E.L.Reinherz
(2000).
Structural basis of cell-cell interactions in the immune system.
|
| |
Curr Opin Struct Biol,
10,
656-661.
|
|
|
|
|
|
|
J.Yagüe,
J.Vázquez,
and
J.A.López de Castro
(2000).
A post-translational modification of nuclear proteins, N(G),N(G)-dimethyl-Arg, found in a natural HLA class I peptide ligand.
|
| |
Protein Sci,
9,
2210-2217.
|
|
|
|
|
|
|
M.Degano,
K.C.Garcia,
V.Apostolopoulos,
M.G.Rudolph,
L.Teyton,
and
I.A.Wilson
(2000).
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.
|
| |
Immunity,
12,
251-261.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.K.Maini,
S.Reignat,
C.Boni,
G.S.Ogg,
A.S.King,
F.Malacarne,
G.J.Webster,
and
A.Bertoletti
(2000).
T cell receptor usage of virus-specific CD8 cells and recognition of viral mutations during acute and persistent hepatitis B virus infection.
|
| |
Eur J Immunol,
30,
3067-3078.
|
|
|
|
|
|
|
N.Burdin,
L.Brossay,
M.Degano,
H.Iijima,
M.Gui,
I.A.Wilson,
and
M.Kronenberg
(2000).
Structural requirements for antigen presentation by mouse CD1.
|
| |
Proc Natl Acad Sci U S A,
97,
10156-10161.
|
|
|
|
|
|
|
O.Schueler-Furman,
Y.Altuvia,
A.Sette,
and
H.Margalit
(2000).
Structure-based prediction of binding peptides to MHC class I molecules: application to a broad range of MHC alleles.
|
| |
Protein Sci,
9,
1838-1846.
|
|
|
|
|
|
|
P.U.Lee,
H.R.Churchill,
M.Daniels,
S.C.Jameson,
and
D.M.Kranz
(2000).
Role of 2CT cell receptor residues in the binding of self- and allo-major histocompatibility complexes.
|
| |
J Exp Med,
191,
1355-1364.
|
|
|
|
|
|
|
A.Glithero,
J.Tormo,
J.S.Haurum,
G.Arsequell,
G.Valencia,
J.Edwards,
S.Springer,
A.Townsend,
Y.L.Pao,
M.Wormald,
R.A.Dwek,
E.Y.Jones,
and
T.Elliott
(1999).
Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity.
|
| |
Immunity,
10,
63-74.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
B.Kessler,
O.Michielin,
C.L.Blanchard,
I.Apostolou,
C.Delarbre,
G.Gachelin,
C.Grégoire,
B.Malissen,
J.C.Cerottini,
F.Wurm,
M.Karplus,
and
I.F.Luescher
(1999).
T cell recognition of hapten. Anatomy of T cell receptor binding of a H-2kd-associated photoreactive peptide derivative.
|
| |
J Biol Chem,
274,
3622-3631.
|
|
|
|
|
|
|
B.M.Baker,
Y.H.Ding,
D.N.Garboczi,
W.E.Biddison,
and
D.C.Wiley
(1999).
Structural, biochemical, and biophysical studies of HLA-A2/altered peptide ligands binding to viral-peptide-specific human T-cell receptors.
|
| |
Cold Spring Harb Symp Quant Biol,
64,
235-241.
|
|
|
|
|
|
|
C.Pinilla,
R.Martin,
B.Gran,
J.R.Appel,
C.Boggiano,
D.B.Wilson,
and
R.A.Houghten
(1999).
Exploring immunological specificity using synthetic peptide combinatorial libraries.
|
| |
Curr Opin Immunol,
11,
193-202.
|
|
|
|
|
|
|
D.B.Moody,
G.S.Besra,
I.A.Wilson,
and
S.A.Porcelli
(1999).
The molecular basis of CD1-mediated presentation of lipid antigens.
|
| |
Immunol Rev,
172,
285-296.
|
|
|
|
|
|
|
D.Bonnin,
B.Prakken,
R.Samodal,
A.La Cava,
D.A.Carson,
and
S.Albani
(1999).
Ontogeny of synonymous T cell populations with specificity for a self MHC epitope mimicked by a bacterial homologoue: an antigen-specific T cell analysis in a non-transgenic system.
|
| |
Eur J Immunol,
29,
3826-3836.
|
|
|
|
|
|
|
D.N.Garboczi,
and
W.E.Biddison
(1999).
Shapes of MHC restriction.
|
| |
Immunity,
10,
1-7.
|
|
|
|
|
|
|
E.Sebzda,
S.Mariathasan,
T.Ohteki,
R.Jones,
M.F.Bachmann,
and
P.S.Ohashi
(1999).
Selection of the T cell repertoire.
|
| |
Annu Rev Immunol,
17,
829-874.
|
|
|
|
|
|
|
H.Li,
A.Llera,
E.L.Malchiodi,
and
R.A.Mariuzza
(1999).
The structural basis of T cell activation by superantigens.
|
| |
Annu Rev Immunol,
17,
435-466.
|
|
|
|
|
|
|
I.Potolicchio,
A.Festucci,
P.Hausler,
and
R.Sorrentino
(1999).
HLA-DP molecules bind cobalt: a possible explanation for the genetic association with hard metal disease.
|
| |
Eur J Immunol,
29,
2140-2147.
|
|
|
|
|
|
|
J.A.Speir,
U.M.Abdel-Motal,
M.Jondal,
and
I.A.Wilson
(1999).
Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL.
|
| |
Immunity,
10,
51-61.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.J.Boniface,
Z.Reich,
D.S.Lyons,
and
M.M.Davis
(1999).
Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning.
|
| |
Proc Natl Acad Sci U S A,
96,
11446-11451.
|
|
|
|
|
|
|
J.Mongkolsapaya,
A.Jaye,
M.F.Callan,
A.F.Magnusen,
A.J.McMichael,
and
H.C.Whittle
(1999).
Antigen-specific expansion of cytotoxic T lymphocytes in acute measles virus infection.
|
| |
J Virol,
73,
67-71.
|
|
|
|
|
|
|
J.Thatte,
A.Qadri,
C.Radu,
and
E.S.Ward
(1999).
Molecular requirements for T cell recognition by a major histocompatibility complex class II-restricted T cell receptor: the involvement of the fourth hypervariable loop of the Valpha domain.
|
| |
J Exp Med,
189,
509-520.
|
|
|
|
|
|
|
K.C.Garcia,
L.Teyton,
and
I.A.Wilson
(1999).
Structural basis of T cell recognition.
|
| |
Annu Rev Immunol,
17,
369-397.
|
|
|
|
|
|
|
K.C.Garcia
(1999).
Molecular interactions between extracellular components of the T-cell receptor signaling complex.
|
| |
Immunol Rev,
172,
73-85.
|
|
|
|
|
|
|
K.Hashimoto,
K.Okamura,
H.Yamaguchi,
M.Ototake,
T.Nakanishi,
and
Y.Kurosawa
(1999).
Conservation and diversification of MHC class I and its related molecules in vertebrates.
|
| |
Immunol Rev,
167,
81.
|
|
|
|
|
|
|
K.Maenaka,
and
E.Y.Jones
(1999).
MHC superfamily structure and the immune system.
|
| |
Curr Opin Struct Biol,
9,
745-753.
|
|
|
|
|
|
|
K.Natarajan,
L.F.Boyd,
P.Schuck,
W.M.Yokoyama,
D.Eliat,
and
D.H.Margulies
(1999).
Interaction of the NK cell inhibitory receptor Ly49A with H-2Dd: identification of a site distinct from the TCR site.
|
| |
Immunity,
11,
591-601.
|
|
|
|
|
|
|
P.Brawand,
J.C.Cerottini,
and
H.R.MacDonald
(1999).
Hierarchal utilization of different T-cell receptor Vbeta gene segments in the CD8(+)-T-cell response to an immunodominant Moloney leukemia virus-encoded epitope in vivo.
|
| |
J Virol,
73,
9161-9169.
|
|
|
|
|
|
|
P.Höllsberg
(1999).
Mechanisms of T-cell activation by human T-cell lymphotropic virus type I.
|
| |
Microbiol Mol Biol Rev,
63,
308-333.
|
|
|
|
|
|
|
P.M.Lavoie,
J.Thibodeau,
F.Erard,
and
R.P.Sékaly
(1999).
Understanding the mechanism of action of bacterial superantigens from a decade of research.
|
| |
Immunol Rev,
168,
257-269.
|
|
|
|
|
|
|
P.S.Andersen,
P.M.Lavoie,
R.P.Sékaly,
H.Churchill,
D.M.Kranz,
P.M.Schlievert,
K.Karjalainen,
and
R.A.Mariuzza
(1999).
Role of the T cell receptor alpha chain in stabilizing TCR-superantigen-MHC class II complexes.
|
| |
Immunity,
10,
473-483.
|
|
|
|
|
|
|
Q.R.Fan,
and
D.C.Wiley
(1999).
Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor.
|
| |
J Exp Med,
190,
113-123.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.A.Lake,
B.W.Robinson,
and
J.D.Hayball
(1999).
MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response.
|
| |
Immunol Cell Biol,
77,
99.
|
|
|
|
|
|
|
R.N.Germain,
and
I.Stefanová
(1999).
The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation.
|
| |
Annu Rev Immunol,
17,
467-522.
|
|
|
|
|
|
|
R.Zhao,
D.J.Loftus,
E.Appella,
and
E.J.Collins
(1999).
Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry.
|
| |
J Exp Med,
189,
359-370.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.C.Manning,
E.A.Parke,
L.Teyton,
and
D.M.Kranz
(1999).
Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing.
|
| |
J Exp Med,
189,
461-470.
|
|
|
|
|
|
|
T.J.Kirksey,
R.R.Pogue-Caley,
J.A.Frelinger,
and
E.J.Collins
(1999).
The structural basis for the increased immunogenicity of two HIV-reverse transcriptase peptide variant/class I major histocompatibility complexes.
|
| |
J Biol Chem,
274,
37259-37264.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.Jensen,
P.Hansen,
A.Faurskov Nielsen,
M.Meldal,
S.Komba,
and
O.Werdelin
(1999).
Shared structural motifs in TCR of glycopeptide-recognizing T cell hybridomas.
|
| |
Eur J Immunol,
29,
2759-2768.
|
|
|
|
|
|
|
Y.H.Ding,
B.M.Baker,
D.N.Garboczi,
W.E.Biddison,
and
D.C.Wiley
(1999).
Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical.
|
| |
Immunity,
11,
45-56.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.A.Janeway
(1998).
A tale of two T cells.
|
| |
Immunity,
8,
391-394.
|
|
|
|
|
|
|
D.Amsen,
and
A.M.Kruisbeek
(1998).
Thymocyte selection: not by TCR alone.
|
| |
Immunol Rev,
165,
209-229.
|
|
|
|
|
|
|
H.Li,
A.Llera,
D.Tsuchiya,
L.Leder,
X.Ysern,
P.M.Schlievert,
K.Karjalainen,
and
R.A.Mariuzza
(1998).
Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B.
|
| |
Immunity,
9,
807-816.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Delon,
C.Grégoire,
B.Malissen,
S.Darche,
F.Lemaître,
P.Kourilsky,
J.P.Abastado,
and
A.Trautmann
(1998).
CD8 expression allows T cell signaling by monomeric peptide-MHC complexes.
|
| |
Immunity,
9,
467-473.
|
|
|
|
|
|
|
K.J.Smith,
J.Pyrdol,
L.Gauthier,
D.C.Wiley,
and
K.W.Wucherpfennig
(1998).
Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein.
|
| |
J Exp Med,
188,
1511-1520.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Feng,
D.Chou,
Y.Liaw,
and
M.Lai
(1998).
Conserved T-cell receptor class II major histocompatibility complex contact detected in a T-lymphocyte population.
|
| |
Immunology,
95,
185-192.
|
|
|
|
|
|
|
P.Bowness,
R.L.Allen,
D.N.Barclay,
E.Y.Jones,
and
A.J.McMichael
(1998).
Importance of a conserved TCR J alpha-encoded tyrosine for T cell recognition of an HLA B27/peptide complex.
|
| |
Eur J Immunol,
28,
2704-2713.
|
|
|
|
|
|
|
T.P.DiLorenzo,
R.T.Graser,
T.Ono,
G.J.Christianson,
H.D.Chapman,
D.C.Roopenian,
S.G.Nathenson,
and
D.V.Serreze
(1998).
Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement.
|
| |
Proc Natl Acad Sci U S A,
95,
12538-12543.
|
|
|
|
|
|
|
Z.Cai,
A.B.Brunmark,
A.T.Luxembourg,
K.C.Garcia,
M.Degano,
L.Teyton,
I.Wilson,
P.A.Peterson,
J.Sprent,
and
M.R.Jackson
(1998).
Probing the activation requirements for naive CD8+ T cells with Drosophila cell transfectants as antigen presenting cells.
|
| |
Immunol Rev,
165,
249-265.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
| |
Links
