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PDBsum entry 1ap8
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Contents |
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* Residue conservation analysis
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PDB id:
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RNA cap
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Title:
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Translation initiation factor eif4e in complex with m7gdp, nmr, 20 structures
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Structure:
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Translation initiation factor eif4e. Chain: a. Engineered: yes
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Source:
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Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Cell_line: bl21 (de3). Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 (de3).
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NMR struc:
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20 models
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Authors:
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H.Matsuo,H.Li,A.M.Mcguire,M.Fletcher,A.C.Gingras,N.Sonenberg,G.Wagner
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Key ref:
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H.Matsuo
et al.
(1997).
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.
Nat Struct Biol,
4,
717-724.
PubMed id:
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Date:
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25-Jul-97
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Release date:
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28-Jan-98
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PROCHECK
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Headers
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References
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P07260
(IF4E_YEAST) -
Eukaryotic translation initiation factor 4E from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
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Seq:
Struc:
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213 a.a.
213 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Nat Struct Biol
4:717-724
(1997)
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PubMed id:
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Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.
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H.Matsuo,
H.Li,
A.M.McGuire,
C.M.Fletcher,
A.C.Gingras,
N.Sonenberg,
G.Wagner.
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ABSTRACT
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eIF4E, the mRNA cap binding protein, is a master switch that controls eukaryotic
translation. To be active, it must bind eIF4G and form the eIF4F complex, which
also contains eIF4A. Translation is downregulated by association of eIF4E with
4E-BP, which occupies the eIF4G binding site. Signalling events acting on 4E-BP
cause it to dissociate from eIF4E, and eIF4E is then free to bind eIF4G to form
the active eIF4F complex. We have solved the structure of the yeast eIF4E/m7Gpp
complex in a CHAPS micelle. We determined the position of the second nucleotide
in a complex with m7GpppA, and identified the 4E-BP binding site. eIF4E has a
curved eight-stranded antiparallel beta-sheet, decorated with three helices on
the convex face and three smaller helices inserted in connecting loops. The m7G
of the cap is intercalated into a stack of tryptophans in the concave face. The
4E-BP binding site is located in a region encompassing one edge of the
beta-sheet, the adjacent helix a2 and several regions of non-regular secondary
structure. It is adjacent to, but does not overlap the cap-binding site.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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K.Ruszczyńska-Bartnik,
M.Maciejczyk,
and
R.Stolarski
(2011).
Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.
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J Mol Model,
17,
727-737.
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P.Gosselin,
N.Oulhen,
M.Jam,
J.Ronzca,
P.Cormier,
M.Czjzek,
and
B.Cosson
(2011).
The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS.
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Nucleic Acids Res,
39,
3496-3503.
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D.R.Schoenberg,
and
L.E.Maquat
(2009).
Re-capping the message.
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Trends Biochem Sci,
34,
435-442.
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H.Okade,
Y.Fujita,
S.Miyamoto,
K.Tomoo,
S.Muto,
H.Miyoshi,
T.Natsuaki,
R.E.Rhoads,
and
T.Ishida
(2009).
Turnip mosaic virus genome-linked protein VPg binds C-terminal region of cap-bound initiation factor 4E orthologue without exhibiting host cellular specificity.
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J Biochem,
145,
299-307.
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H.Sato,
and
L.E.Maquat
(2009).
Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta.
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Genes Dev,
23,
2537-2550.
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M.A.Khan,
H.Yumak,
and
D.J.Goss
(2009).
Kinetic mechanism for the binding of eIF4F and tobacco Etch virus internal ribosome entry site rna: effects of eIF4B and poly(A)-binding protein.
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J Biol Chem,
284,
35461-35470.
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M.Franzmann,
D.Otzen,
and
R.Wimmer
(2009).
Quantitative use of paramagnetic relaxation enhancements for determining orientations and insertion depths of peptides in micelles.
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Chembiochem,
10,
2339-2347.
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M.Hemond,
T.L.Rothstein,
and
G.Wagner
(2009).
Fas apoptosis inhibitory molecule contains a novel beta-sandwich in contact with a partially ordered domain.
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J Mol Biol,
386,
1024-1037.
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PDB code:
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R.E.Rhoads
(2009).
eIF4E: New Family Members, New Binding Partners, New Roles.
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J Biol Chem,
284,
16711-16715.
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R.Tuteja
(2009).
Identification and bioinformatics characterization of translation initiation complex eIF4F components and poly(A)-binding protein from Plasmodium falciparum.
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Commun Integr Biol,
2,
245-260.
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W.Liu,
R.Zhao,
C.McFarland,
J.Kieft,
A.Niedzwiecka,
M.Jankowska-Anyszka,
J.Stepinski,
E.Darzynkiewicz,
D.N.Jones,
and
R.E.Davis
(2009).
Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps.
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J Biol Chem,
284,
31336-31349.
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PDB codes:
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H.Dong,
S.Ren,
B.Zhang,
Y.Zhou,
F.Puig-Basagoiti,
H.Li,
and
P.Y.Shi
(2008).
West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism.
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J Virol,
82,
4295-4307.
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I.Y.Tcherepanova,
M.D.Adams,
X.Feng,
A.Hinohara,
J.Horvatinovich,
D.Calderhead,
D.Healey,
and
C.A.Nicolette
(2008).
Ectopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion.
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BMC Mol Biol,
9,
90.
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K.M.Chen,
E.Harjes,
P.J.Gross,
A.Fahmy,
Y.Lu,
K.Shindo,
R.S.Harris,
and
H.Matsuo
(2008).
Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G.
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Nature,
452,
116-119.
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PDB code:
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K.Treder,
E.L.Kneller,
E.M.Allen,
Z.Wang,
K.S.Browning,
and
W.A.Miller
(2008).
The 3' cap-independent translation element of Barley yellow dwarf virus binds eIF4F via the eIF4G subunit to initiate translation.
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RNA,
14,
134-147.
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L.Lindqvist,
M.Oberer,
M.Reibarkh,
R.Cencic,
M.E.Bordeleau,
E.Vogt,
A.Marintchev,
J.Tanaka,
F.Fagotto,
M.Altmann,
G.Wagner,
and
J.Pelletier
(2008).
Selective pharmacological targeting of a DEAD box RNA helicase.
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PLoS ONE,
3,
e1583.
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M.A.Mir,
and
A.T.Panganiban
(2008).
A protein that replaces the entire cellular eIF4F complex.
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EMBO J,
27,
3129-3139.
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M.V.Deshmukh,
B.N.Jones,
D.U.Quang-Dang,
J.Flinders,
S.N.Floor,
C.Kim,
J.Jemielity,
M.Kalek,
E.Darzynkiewicz,
and
J.D.Gross
(2008).
mRNA decapping is promoted by an RNA-binding channel in Dcp2.
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Mol Cell,
29,
324-336.
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PDB code:
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R.Grzela,
E.Szolajska,
C.Ebel,
D.Madern,
A.Favier,
I.Wojtal,
W.Zagorski,
and
J.Chroboczek
(2008).
Virulence factor of potato virus Y, genome-attached terminal protein VPg, is a highly disordered protein.
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J Biol Chem,
283,
213-221.
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S.V.Slepenkov,
N.L.Korneeva,
and
R.E.Rhoads
(2008).
Kinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complex.
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J Biol Chem,
283,
25227-25237.
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H.K.Saini,
and
D.Fischer
(2007).
Structural and functional insights into Mimivirus ORFans.
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BMC Genomics,
8,
115.
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J.Zuberek,
D.Kubacka,
A.Jablonowska,
J.Jemielity,
J.Stepinski,
N.Sonenberg,
and
E.Darzynkiewicz
(2007).
Weak binding affinity of human 4EHP for mRNA cap analogs.
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RNA,
13,
691-697.
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N.J.Moerke,
H.Aktas,
H.Chen,
S.Cantel,
M.Y.Reibarkh,
A.Fahmy,
J.D.Gross,
A.Degterev,
J.Yuan,
M.Chorev,
J.A.Halperin,
and
G.Wagner
(2007).
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.
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Cell,
128,
257-267.
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P.Nilsson,
N.Henriksson,
A.Niedzwiecka,
N.A.Balatsos,
K.Kokkoris,
J.Eriksson,
and
A.Virtanen
(2007).
A multifunctional RNA recognition motif in poly(A)-specific ribonuclease with cap and poly(A) binding properties.
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J Biol Chem,
282,
32902-32911.
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A.Schmidt,
A.Lindner,
M.Nieger,
M.d.e.l. .C.Ruiz-Delgado,
and
F.J.Ramirez
(2006).
Syntheses, pi-stacking interactions and base-pairings of uracil pyridinium salts and uracilyl betaines with nucleobases.
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Org Biomol Chem,
4,
3056-3066.
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E.Grudzien,
M.Kalek,
J.Jemielity,
E.Darzynkiewicz,
and
R.E.Rhoads
(2006).
Differential inhibition of mRNA degradation pathways by novel cap analogs.
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J Biol Chem,
281,
1857-1867.
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M.P.Hall,
and
C.K.Ho
(2006).
Functional characterization of a 48 kDa Trypanosoma brucei cap 2 RNA methyltransferase.
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Nucleic Acids Res,
34,
5594-5602.
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M.Reibarkh,
T.J.Malia,
B.T.Hopkins,
and
G.Wagner
(2006).
Identification of individual protein-ligand NOEs in the limit of intermediate exchange.
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J Biomol NMR,
36,
1.
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S.V.Slepenkov,
E.Darzynkiewicz,
and
R.E.Rhoads
(2006).
Stopped-flow kinetic analysis of eIF4E and phosphorylated eIF4E binding to cap analogs and capped oligoribonucleotides: evidence for a one-step binding mechanism.
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J Biol Chem,
281,
14927-14938.
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A.Kentsis,
L.Volpon,
I.Topisirovic,
C.E.Soll,
B.Culjkovic,
L.Shao,
and
K.L.Borden
(2005).
Further evidence that ribavirin interacts with eIF4E.
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RNA,
11,
1762-1766.
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A.Strasser,
A.Dickmanns,
R.Lührmann,
and
R.Ficner
(2005).
Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1.
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EMBO J,
24,
2235-2243.
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PDB code:
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B.Joshi,
K.Lee,
D.L.Maeder,
and
R.Jagus
(2005).
Phylogenetic analysis of eIF4E-family members.
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BMC Evol Biol,
5,
48.
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E.Bitto,
C.A.Bingman,
H.Robinson,
S.T.Allard,
G.E.Wesenberg,
and
G.N.Phillips
(2005).
The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03.
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Acta Crystallogr Sect F Struct Biol Cryst Commun,
61,
812-817.
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PDB code:
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J.D.Richter,
and
N.Sonenberg
(2005).
Regulation of cap-dependent translation by eIF4E inhibitory proteins.
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Nature,
433,
477-480.
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J.D.Swarbrick,
S.Buyya,
D.Gunawardana,
K.R.Gayler,
A.G.McLennan,
and
P.R.Gooley
(2005).
Structure and substrate-binding mechanism of human Ap4A hydrolase.
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J Biol Chem,
280,
8471-8481.
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PDB codes:
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K.Mochizuki,
A.Oguro,
T.Ohtsu,
N.Sonenberg,
and
Y.Nakamura
(2005).
High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation.
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RNA,
11,
77-89.
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L.Li,
and
C.C.Wang
(2005).
Identification in the ancient protist Giardia lamblia of two eukaryotic translation initiation factor 4E homologues with distinctive functions.
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Eukaryot Cell,
4,
948-959.
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P.F.Cho,
F.Poulin,
Y.A.Cho-Park,
I.B.Cho-Park,
J.D.Chicoine,
P.Lasko,
and
N.Sonenberg
(2005).
A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP.
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Cell,
121,
411-423.
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R.Majumdar,
and
U.Maitra
(2005).
Regulation of GTP hydrolysis prior to ribosomal AUG selection during eukaryotic translation initiation.
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EMBO J,
24,
3737-3746.
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R.Worch,
A.Niedzwiecka,
J.Stepinski,
C.Mazza,
M.Jankowska-Anyszka,
E.Darzynkiewicz,
S.Cusack,
and
R.Stolarski
(2005).
Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complex.
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RNA,
11,
1355-1363.
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T.D.Dinkova,
B.D.Keiper,
N.L.Korneeva,
E.J.Aamodt,
and
R.E.Rhoads
(2005).
Translation of a small subset of Caenorhabditis elegans mRNAs is dependent on a specific eukaryotic translation initiation factor 4E isoform.
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Mol Cell Biol,
25,
100-113.
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Y.Yan,
Y.Svitkin,
J.M.Lee,
M.Bisaillon,
and
J.Pelletier
(2005).
Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap.
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RNA,
11,
1238-1244.
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B.Joshi,
A.Cameron,
and
R.Jagus
(2004).
Characterization of mammalian eIF4E-family members.
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| |
Eur J Biochem,
271,
2189-2203.
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E.Grudzien,
J.Stepinski,
M.Jankowska-Anyszka,
R.Stolarski,
E.Darzynkiewicz,
and
R.E.Rhoads
(2004).
Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency.
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RNA,
10,
1479-1487.
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I.Bougie,
and
M.Bisaillon
(2004).
The broad spectrum antiviral nucleoside ribavirin as a substrate for a viral RNA capping enzyme.
|
| |
J Biol Chem,
279,
22124-22130.
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J.Robalino,
B.Joshi,
S.C.Fahrenkrug,
and
R.Jagus
(2004).
Two zebrafish eIF4E family members are differentially expressed and functionally divergent.
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| |
J Biol Chem,
279,
10532-10541.
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L.D.Kapp,
and
J.R.Lorsch
(2004).
The molecular mechanics of eukaryotic translation.
|
| |
Annu Rev Biochem,
73,
657-704.
|
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M.Lewdorowicz,
Y.Yoffe,
J.Zuberek,
J.Jemielity,
J.Stepinski,
R.Kierzek,
R.Stolarski,
M.Shapira,
and
E.Darzynkiewicz
(2004).
Chemical synthesis and binding activity of the trypanosomatid cap-4 structure.
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| |
RNA,
10,
1469-1478.
|
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T.von der Haar,
J.D.Gross,
G.Wagner,
and
J.E.McCarthy
(2004).
The mRNA cap-binding protein eIF4E in post-transcriptional gene expression.
|
| |
Nat Struct Mol Biol,
11,
503-511.
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A.Gradi,
Y.V.Svitkin,
W.Sommergruber,
H.Imataka,
S.Morino,
T.Skern,
and
N.Sonenberg
(2003).
Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different.
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J Virol,
77,
5026-5029.
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J.D.Gross,
N.J.Moerke,
T.von der Haar,
A.A.Lugovskoy,
A.B.Sachs,
J.E.McCarthy,
and
G.Wagner
(2003).
Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E.
|
| |
Cell,
115,
739-750.
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PDB code:
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J.Jemielity,
T.Fowler,
J.Zuberek,
J.Stepinski,
M.Lewdorowicz,
A.Niedzwiecka,
R.Stolarski,
E.Darzynkiewicz,
and
R.E.Rhoads
(2003).
Novel "anti-reverse" cap analogs with superior translational properties.
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| |
RNA,
9,
1108-1122.
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K.Ruszczynska,
K.Kamienska-Trela,
J.Wojcik,
J.Stepinski,
E.Darzynkiewicz,
and
R.Stolarski
(2003).
Charge distribution in 7-methylguanine regarding cation-pi interaction with protein factor eIF4E.
|
| |
Biophys J,
85,
1450-1456.
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N.Sonenberg,
and
T.E.Dever
(2003).
Eukaryotic translation initiation factors and regulators.
|
| |
Curr Opin Struct Biol,
13,
56-63.
|
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P.Fechter,
L.Mingay,
J.Sharps,
A.Chambers,
E.Fodor,
and
G.G.Brownlee
(2003).
Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding.
|
| |
J Biol Chem,
278,
20381-20388.
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S.J.Freedman,
Z.Y.Sun,
A.L.Kung,
D.S.France,
G.Wagner,
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Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.
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Nat Struct Biol,
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PDB code:
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T.Preiss,
and
M.W Hentze
(2003).
Starting the protein synthesis machine: eukaryotic translation initiation.
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Bioessays,
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T.V.Pestova,
and
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Coupled folding during translation initiation.
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Cell,
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Purifying mRNAs with a high-affinity eIF4E mutant identifies the short 3' poly(A) end phenotype.
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Proc Natl Acad Sci U S A,
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C.M.Groft,
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(2002).
Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization.
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Mol Cell,
9,
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PDB code:
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C.Mazza,
A.Segref,
I.W.Mattaj,
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Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex.
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EMBO J,
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PDB codes:
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G.C.Scheper,
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D.J.Goss,
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Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.
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J Biol Chem,
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G.C.Scheper,
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Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?
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Eur J Biochem,
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Nat Struct Biol,
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Discrimination between mono- and trimethylated cap structures by two isoforms of Caenorhabditis elegans eIF4E.
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EMBO J,
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The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site.
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EMBO J,
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PDB codes:
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S.J.Freedman,
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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
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Proc Natl Acad Sci U S A,
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PDB code:
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S.Ruffel,
M.H.Dussault,
A.Palloix,
B.Moury,
A.Bendahmane,
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A natural recessive resistance gene against potato virus Y in pepper corresponds to the eukaryotic initiation factor 4E (eIF4E).
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Plant J,
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Curr Opin Struct Biol,
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Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG.
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RNA,
7,
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The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits.
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EMBO J,
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W.Li,
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Structure and dynamics of translation initiation factor aIF-1A from the archaeon Methanococcus jannaschii determined by NMR spectroscopy.
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Protein Sci,
10,
2426-2438.
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PDB code:
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X.Shen,
K.Tomoo,
S.Uchiyama,
Y.Kobayashi,
and
T.Ishida
(2001).
Structural and thermodynamic behavior of eukaryotic initiation factor 4E in supramolecular formation with 4E-binding protein 1 and mRNA cap analogue, studied by spectroscopic methods.
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Chem Pharm Bull (Tokyo),
49,
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Z.J.Sun,
K.S.Kim,
G.Wagner,
and
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(2001).
Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.
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Cell,
105,
913-923.
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PDB code:
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A.N.Kuhn,
and
D.A.Brow
(2000).
Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation.
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Genetics,
155,
1667-1682.
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F.A.Quiocho,
G.Hu,
and
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Structural basis of mRNA cap recognition by proteins.
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Curr Opin Struct Biol,
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J.L.Battiste,
and
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(2000).
Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data.
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Biochemistry,
39,
5355-5365.
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J.R.Dyer,
and
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(2000).
Regulation of eukaryotic initiation factor 4E phosphorylation in the nervous system of Aplysia californica.
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J Neurochem,
75,
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J.T.Brown,
X.Yang,
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(2000).
Inhibition of mRNA turnover in yeast by an xrn1 mutation enhances the requirement for eIF4E binding to eIF4G and for proper capping of transcripts by Ceg1p.
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Genetics,
155,
31-42.
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L.Aravind,
and
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(2000).
Eukaryote-specific domains in translation initiation factors: implications for translation regulation and evolution of the translation system.
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Genome Res,
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1172-1184.
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S.C.Fahrenkrug,
B.Joshi,
P.B.Hackett,
and
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(2000).
Alternative transcriptional initiation and splicing define the translational efficiencies of zebrafish mRNAs encoding eukaryotic initiation factor 4E.
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Differentiation,
66,
15-22.
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A.C.Gingras,
B.Raught,
and
N.Sonenberg
(1999).
eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
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Annu Rev Biochem,
68,
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A.C.Gingras,
S.P.Gygi,
B.Raught,
R.D.Polakiewicz,
R.T.Abraham,
M.F.Hoekstra,
R.Aebersold,
and
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(1999).
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
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Genes Dev,
13,
1422-1437.
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A.Cai,
M.Jankowska-Anyszka,
A.Centers,
L.Chlebicka,
J.Stepinski,
R.Stolarski,
E.Darzynkiewicz,
and
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(1999).
Quantitative assessment of mRNA cap analogues as inhibitors of in vitro translation.
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Biochemistry,
38,
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A.J.Waskiewicz,
J.C.Johnson,
B.Penn,
M.Mahalingam,
S.R.Kimball,
and
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(1999).
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.
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Mol Cell Biol,
19,
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A.Lampio,
T.Ahola,
E.Darzynkiewicz,
J.Stepinski,
M.Jankowska-Anyszka,
and
L.Kääriäinen
(1999).
Guanosine nucleotide analogs as inhibitors of alphavirus mRNA capping enzyme.
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Antiviral Res,
42,
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B.Raught,
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eIF4E activity is regulated at multiple levels.
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Int J Biochem Cell Biol,
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J.J.Chou,
H.Li,
G.S.Salvesen,
J.Yuan,
and
G.Wagner
(1999).
Solution structure of BID, an intracellular amplifier of apoptotic signaling.
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Cell,
96,
615-624.
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PDB code:
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|
J.Marcotrigiano,
A.C.Gingras,
N.Sonenberg,
and
S.K.Burley
(1999).
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.
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Mol Cell,
3,
707-716.
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PDB codes:
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J.R.Lorsch,
and
D.Herschlag
(1999).
Kinetic dissection of fundamental processes of eukaryotic translation initiation in vitro.
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EMBO J,
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K.J.Walters,
G.T.Gassner,
S.J.Lippard,
and
G.Wagner
(1999).
Structure of the soluble methane monooxygenase regulatory protein B.
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Proc Natl Acad Sci U S A,
96,
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PDB code:
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|
L.McKendrick,
V.M.Pain,
and
S.J.Morley
(1999).
Translation initiation factor 4E.
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Int J Biochem Cell Biol,
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M.Ptushkina,
T.von der Haar,
M.M.Karim,
J.M.Hughes,
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(1999).
Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state.
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EMBO J,
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P.Zhou,
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(1999).
Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction.
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Proc Natl Acad Sci U S A,
96,
11265-11270.
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PDB code:
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S.Manjunath,
A.J.Williams,
and
J.Bailey-Serres
(1999).
Oxygen deprivation stimulates Ca2+-mediated phosphorylation of mRNA cap-binding protein eIF4E in maize roots.
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Plant J,
19,
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S.Pyronnet,
H.Imataka,
A.C.Gingras,
R.Fukunaga,
T.Hunter,
and
N.Sonenberg
(1999).
Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
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EMBO J,
18,
270-279.
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S.Tharun,
and
R.Parker
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Analysis of mutations in the yeast mRNA decapping enzyme.
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Genetics,
151,
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T.V.Pestova,
and
C.U.Hellen
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Ribosome recruitment and scanning: what's new?
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Trends Biochem Sci,
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Z.Y.Sun,
V.Dötsch,
M.Kim,
J.Li,
E.L.Reinherz,
and
G.Wagner
(1999).
Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies.
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EMBO J,
18,
2941-2949.
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PDB code:
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A.Gradi,
Y.V.Svitkin,
H.Imataka,
and
N.Sonenberg
(1998).
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection.
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Proc Natl Acad Sci U S A,
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(1998).
NMR structure determination of proteins and protein complexes larger than 20 kDa.
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K.Nagai
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RNA recognition by RNP proteins during RNA processing.
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Annu Rev Biophys Biomol Struct,
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B.J.de la Cruz,
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Control of mRNA turnover as a mechanism of glucose repression in Saccharomyces cerevisiae.
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J.E.McCarthy
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Posttranscriptional control of gene expression in yeast.
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Microbiol Mol Biol Rev,
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H.Matsuo,
H.Duan,
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(1998).
Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment.
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Cell,
94,
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PDB code:
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J.R.Dyer,
A.M.Pepio,
S.K.Yanow,
and
W.S.Sossin
(1998).
Phosphorylation of eIF4E at a conserved serine in Aplysia.
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J Biol Chem,
273,
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K.A.Ruud,
C.Kuhlow,
D.J.Goss,
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(1998).
Identification and characterization of a novel cap-binding protein from Arabidopsis thaliana.
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J Biol Chem,
273,
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M.Jankowska-Anyszka,
B.J.Lamphear,
E.J.Aamodt,
T.Harrington,
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R.Stolarski,
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(1998).
Multiple isoforms of eukaryotic protein synthesis initiation factor 4E in Caenorhabditis elegans can distinguish between mono- and trimethylated mRNA cap structures.
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J Biol Chem,
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M.Ptushkina,
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R.Frank,
R.Birkenhäger,
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Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20.
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EMBO J,
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N.Sonenberg,
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The mRNA 5' cap-binding protein eIF4E and control of cell growth.
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Curr Opin Cell Biol,
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N.Sonenberg,
S.K.Burley,
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RNA chiropractics.
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Nat Struct Biol,
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X.Wang,
A.Flynn,
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I.A.Baines,
J.A.Cooper,
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(1998).
The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways.
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J Biol Chem,
273,
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
|
Links
