PDBsum entry 1amn

Hydrolase (serine esterase)

PDB id: 1amn

Contents

Protein chain

526 a.a. *

Ligands

SO4

NAF

Waters ×297

* Residue conservation analysis

PDB id:

1amn

Name:

Hydrolase (serine esterase)

Title:

Transition state analog: acetylcholinesterase complexed with m-(n,n,n- trimethylammonio)trifluoroacetophenone

Structure:

Acetylcholinesterase. Chain: a. Ec: 3.1.1.7

Source:

Torpedo californica. Pacific electric ray. Organism_taxid: 7787. Organ: electric organ

Resolution:

2.80Å R-factor: 0.188 R-free: 0.235

Authors:

M.Harel,I.Silman,J.L.Sussman

Key ref:

M.Harel et al. (1996). The X-Ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.. J am chem soc, 118, 2340-2346.

Date:

13-Feb-96 Release date: 03-Apr-96

Protein chain

P04058  (ACES_TETCF) -  Acetylcholinesterase from Tetronarce californica

Seq: 586 a.a.

Struc: 526 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.1.7 - acetylcholinesterase.
• Reaction: acetylcholine + H2O = choline + acetate + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site