 |
PDBsum entry 1a9v
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
DOI no:
|
Biochemistry
37:12707-12714
(1998)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Tertiary structure of the major house dust mite allergen Der p 2: sequential and structural homologies.
|
|
G.A.Mueller,
D.C.Benjamin,
G.S.Rule.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
Sensitization to indoor allergens, especially those of the house dust mite, is
strongly correlated with the development of asthma. We report the tertiary
structure of the major house dust mite allergen, Der p 2, determined by NMR
methods. The structure of Der p 2 is a beta-barrel and is composed of two
three-stranded antiparallel beta-pleated sheets. This arrangement of
beta-strands is similar to the immunoglobulin fold with respect to the
orientation of the two sheets and the interactions of the strands. However, the
three-dimensional structure of Der p 2 aligns equivalently with a number of
proteins from different families within the immunoglobulin superfamily. The
structural homology with the highest significance score from analysis by DALI is
to Der f 2. Although Der p 2 and Der f 2 are 87% identical in amino acid
sequence, they align in three dimensions rather poorly (4.85 A RMSD; Z-score,
8.58). This unexpected finding is likely due to the different solution
conditions used during structure determination by NMR for both proteins. While
the structural comparisons did not elucidate a clear homologue for the function
of Der p 2 in mites, we report that Der p 2 is sequentially homologous to esr16.
This is a protein from moths that is expressed coincident with molting. Thus,
this homology has important ramifications for the study of mite allergy. The
structure of Der p 2 provides a useful tool in the design of recombinant
immunotherapeutics for the group 2 allergens.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
J.Horácková,
N.Rudenko,
M.Golovchenko,
and
L.Grubhoffer
(2010).
Der-p2 ( Dermatophagoides pteronyssinus) allergen-like protein from the hard tick Ixodes ricinus - a novel member of ML (MD-2-related lipid-recognition) domain protein family.
|
| |
Parasitology,
137,
1139-1149.
|
|
|
|
|
|
|
K.E.Loft,
and
E.J.Rosser
(2010).
Group 1 and 2 Dermatophagoides house dust mite allergens in the microenvironment of cats.
|
| |
Vet Dermatol,
21,
152-158.
|
|
|
|
|
|
|
R.van Ree,
M.D.Chapman,
F.Ferreira,
S.Vieths,
D.Bryan,
O.Cromwell,
M.Villalba,
S.R.Durham,
W.M.Becker,
M.Aalbers,
C.André,
D.Barber,
A.Cistero Bahima,
A.Custovic,
A.Didierlaurent,
C.Dolman,
J.W.Dorpema,
G.Di Felice,
F.Eberhardt,
E.Fernandez Caldas,
M.Fernandez Rivas,
H.Fiebig,
M.Focke,
K.Fötisch,
G.Gadermaier,
R.G.Das,
E.Gonzalez Mancebo,
M.Himly,
T.Kinaciyan,
A.C.Knulst,
A.M.Kroon,
U.Lepp,
F.M.Marco,
A.Mari,
P.Moingeon,
R.Monsalve,
A.Neubauer,
S.Notten,
P.Ooievaar-de Heer,
G.Pauli,
C.Pini,
A.Purohit,
J.Quiralte,
S.Rak,
M.Raulf-Heimsoth,
M.M.San Miguel Moncin,
B.Simpson,
A.Tsay,
L.Vailes,
M.Wallner,
and
B.Weber
(2008).
The CREATE project: development of certified reference materials for allergenic products and validation of methods for their quantification.
|
| |
Allergy,
63,
310-326.
|
|
|
|
|
|
|
D.Lienard,
O.Tran Dinh,
E.van Oort,
L.Van Overtvelt,
C.Bonneau,
E.Wambre,
M.Bardor,
P.Cosette,
A.Didier-Laurent,
F.D.de Borne,
R.Delon,
R.van Ree,
P.Moingeon,
L.Faye,
and
V.Gomord
(2007).
Suspension-cultured BY-2 tobacco cells produce and mature immunologically active house dust mite allergens.
|
| |
Plant Biotechnol J,
5,
93.
|
|
|
|
|
|
|
W.R.Thomas,
and
B.J.Hales
(2007).
T and B cell responses to HDM allergens and antigens.
|
| |
Immunol Res,
37,
187-199.
|
|
|
|
|
|
|
T.J.Nuttall,
P.B.Hill,
E.Bensignor,
and
T.Willemse
(2006).
House dust and forage mite allergens and their role in human and canine atopic dermatitis.
|
| |
Vet Dermatol,
17,
223-235.
|
|
|
|
|
|
|
E.Raffan,
H.Lawrence,
T.Henderson,
S.Nelson,
D.Isherwood,
C.McArdle,
and
T.Nuttall
(2005).
Prevalence of the group 1 Dermatophagoides allergens Der p 1 and Der f 1 in homes with no dogs, healthy dogs and Dermatophagoides-sensitized atopic dogs in Liverpool.
|
| |
Vet Dermatol,
16,
253-260.
|
|
|
|
|
|
|
A.Gruber,
M.Mancek,
H.Wagner,
C.J.Kirschning,
and
R.Jerala
(2004).
Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition.
|
| |
J Biol Chem,
279,
28475-28482.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.C.Ko,
J.Binkley,
A.Sidow,
and
M.P.Scott
(2003).
The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.
|
| |
Proc Natl Acad Sci U S A,
100,
2518-2525.
|
|
|
|
|
|
|
D.Roeber,
A.Achari,
T.Takai,
Y.Okumura,
and
D.L.Scott
(2003).
Crystallization and preliminary X-ray analysis of Der f 2, a potent allergen derived from the house dust mite (Dermatophagoides farinae).
|
| |
Acta Crystallogr D Biol Crystallogr,
59,
1046-1048.
|
|
|
|
|
|
|
N.Friedland,
H.L.Liou,
P.Lobel,
and
A.M.Stock
(2003).
Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease.
|
| |
Proc Natl Acad Sci U S A,
100,
2512-2517.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.P.Trombone,
K.R.Tobias,
V.P.Ferriani,
J.Schuurman,
R.C.Aalberse,
A.M.Smith,
M.D.Chapman,
and
L.K.Arruda
(2002).
Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and/or rhinitis.
|
| |
Clin Exp Allergy,
32,
1323-1328.
|
|
|
|
|
|
|
A.Pomés
(2002).
Intrinsic properties of allergens and environmental exposure as determinants of allergenicity.
|
| |
Allergy,
57,
673-679.
|
|
|
|
|
|
|
A.Tsay,
L.Williams,
E.B.Mitchell,
and
M.D.Chapman
(2002).
A rapid test for detection of mite allergens in homes.
|
| |
Clin Exp Allergy,
32,
1596-1601.
|
|
|
|
|
|
|
B.J.Hales,
L.A.Hazell,
W.Smith,
and
W.R.Thomas
(2002).
Genetic variation of Der p 2 allergens: effects on T cell responses and immunoglobulin E binding.
|
| |
Clin Exp Allergy,
32,
1461-1467.
|
|
|
|
|
|
|
K.B.Temeyer,
L.C.Soileau,
and
J.H.Pruett
(2002).
Cloning and sequence analysis of a cDNA encoding Pso o II, a mite group II allergen of the sheep scab mite (Acari: Psoroptidae).
|
| |
J Med Entomol,
39,
384-391.
|
|
|
|
|
|
|
K.Y.Jeong,
I.Y.Lee,
H.I.Ree,
C.S.Hong,
and
T.S.Yong
(2002).
Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae.
|
| |
Allergy,
57,
729-731.
|
|
|
|
|
|
|
L.G.Arlian
(2002).
Arthropod allergens and human health.
|
| |
Annu Rev Entomol,
47,
395-433.
|
|
|
|
|
|
|
R.Rodríguez,
M.Villalba,
E.Batanero,
E.M.González,
R.I.Monsalve,
S.Huecas,
M.L.Tejera,
and
A.Ledesma
(2002).
Allergenic diversity of the olive pollen.
|
| |
Allergy,
57,
6.
|
|
|
|
|
|
|
R.van Ree
(2002).
Isoallergens: a clinically relevant phenomenon or just a product of cloning?
|
| |
Clin Exp Allergy,
32,
975-978.
|
|
|
|
|
|
|
A.Pomés,
and
M.D.Chapman
(2001).
Can knowledge of the molecular structure of allergens improve immunotherapy?
|
| |
Curr Opin Allergy Clin Immunol,
1,
549-554.
|
|
|
|
|
|
|
M.D.Chapman,
A.Tsay,
and
L.D.Vailes
(2001).
Home allergen monitoring and control--improving clinical practice and patient benefits.
|
| |
Allergy,
56,
604-610.
|
|
|
|
|
|
|
T.Takai,
M.Akagawa-Chihara,
T.Yokota,
and
Y.Okumura
(2001).
Reactivities of mutants of a major house dust mite allergen Der f 2 to mouse anti-Der f 2 monoclonal antibodies analyzed by immunoblotting.
|
| |
Biosci Biotechnol Biochem,
65,
694-697.
|
|
|
|
|
|
|
K.V.Soman,
T.Midoro-Horiuti,
J.C.Ferreon,
R.M.Goldblum,
E.G.Brooks,
A.Kurosky,
W.Braun,
and
C.H.Schein
(2000).
Homology modeling and characterization of IgE binding epitopes of mountain cedar allergen Jun a 3.
|
| |
Biophys J,
79,
1601-1609.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
T.Takai,
S.Ichikawa,
H.Hatanaka,
F.Inagaki,
and
Y.Okumura
(2000).
Effects of proline mutations in the major house dust mite allergen Der f 2 on IgE-binding and histamine-releasing activity.
|
| |
Eur J Biochem,
267,
6650-6656.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
|
Links
