PDBsum entry 1xq7

Isomerase/immunosuppressant

PDB id: 1xq7

Contents

Protein chains

166 a.a. *

11 a.a. *

Waters ×288

* Residue conservation analysis

PDB id:

1xq7

Name:

Isomerase/immunosuppressant

Title:

Cyclophilin from trypanosoma cruzi bound to cyclosporin a

Structure:

Peptidyl-prolyl cis-trans isomerase. Chain: a, b, c. Synonym: ppiase, rotamase, cyclophilin a. Engineered: yes. Cyclosporin a. Chain: d, e, f. Synonym: cyclosporine, ciclosporin, ciclosporine. Engineered: yes

Source:

Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Tolypocladium inflatum 2. Organism_taxid: 29910

Resolution:

2.07Å R-factor: 0.172 R-free: 0.235

Authors:

J.M.Caruthers,W.G.J.Hol,Structural Genomics Of Pathogenic Protozoa Consortium (Sgpp)

Key ref:

J.M.Caruthers et al. Cyclophilin from trypanosoma cruzi bound to cyclosporin a. To be published, .

Date:

11-Oct-04 Release date: 21-Dec-04

Protein chains

Q4DPB9  (Q4DPB9_TRYCC) -  Peptidyl-prolyl cis-trans isomerase from Trypanosoma cruzi (strain CL Brener)

Seq: 194 a.a.

Struc: 166 a.a.*

Protein chains

No UniProt id for this chain

Struc: 11 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains A, B, C: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site