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PDBsum entry 1mzb
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protein metals links
Gene regulation PDB id
1mzb

 

 

 

 

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JSmol PyMol  
Contents
Protein chain
133 a.a. *
Metals
_ZN ×4
Waters ×126
* Residue conservation analysis
PDB id:
1mzb
Name: Gene regulation
Title: Ferric uptake regulator
Structure: Ferric uptake regulation protein. Chain: a. Synonym: ferric uptake regulator. Engineered: yes
Source: Pseudomonas aeruginosa. Organism_taxid: 287. Expressed in: escherichia coli. Expression_system_taxid: 562
Biol. unit: Tetramer (from PDB file)
Resolution:
1.80Å     R-factor:   0.226     R-free:   0.254
Authors: E.Pohl,M.L.Vasil,J.C.Haller
Key ref: E.Pohl et al. (2003). Architecture of a protein central to iron homeostasis: crystal structure and spectroscopic analysis of the ferric uptake regulator. Mol Microbiol, 47, 903-915. PubMed id: 12581348
Date:
07-Oct-02     Release date:   07-Oct-03    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q03456  (FUR_PSEAE) -  Ferric uptake regulation protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Seq:
Struc: 		134 a.a.
133 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
Mol Microbiol 47:903-915 (2003)
PubMed id: 12581348  
 
 
Architecture of a protein central to iron homeostasis: crystal structure and spectroscopic analysis of the ferric uptake regulator.
E.Pohl, J.C.Haller, A.Mijovilovich, W.Meyer-Klaucke, E.Garman, M.L.Vasil.
 
  ABSTRACT  
 
Iron is an essential element for almost all organisms, although an overload of this element results in toxicity because of the formation of hydroxyl radicals. Consequently, most living entities have developed sophisticated mechanisms to control their intracellular iron concentration. In many bacteria, including the opportunistic pathogen Pseudomonas aeruginosa, this task is performed by the ferric uptake regulator (Fur). Fur controls a wide variety of basic physiological processes including iron uptake systems and the expression of exotoxin A. Here, we present the first crystal structure of Fur from P. aeruginosa in complex with Zn2+ determined at a resolution of 1.8 A. Furthermore, X-ray absorption spectroscopic measurements and microPIXE analysis were performed in order to characterize the distinct zinc and iron binding sites in solution. The combination of these complementary techniques enables us to present a model for the activation and DNA binding of the Fur protein.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21292540 A.S.Fleischhacker, and P.J.Kiley (2011).
Iron-containing transcription factors and their roles as sensors.
  Curr Opin Chem Biol, 15, 335-341.  
21208302 C.Dian, S.Vitale, G.A.Leonard, C.Bahlawane, C.Fauquant, D.Leduc, C.Muller, H.de Reuse, I.Michaud-Soret, and L.Terradot (2011).
The structure of the Helicobacter pylori ferric uptake regulator Fur reveals three functional metal binding sites.
  Mol Microbiol, 79, 1260-1275.
PDB code: 2xig
21244531 H.Ando, T.Kitao, T.Miyoshi-Akiyama, S.Kato, T.Mori, and T.Kirikae (2011).
Downregulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis.
  Mol Microbiol, 79, 1615-1628.  
21383173 J.H.Shin, H.J.Jung, Y.J.An, Y.B.Cho, S.S.Cha, and J.H.Roe (2011).
Graded expression of zinc-responsive genes through two regulatory zinc-binding sites in Zur.
  Proc Natl Acad Sci U S A, 108, 5045-5050.
PDB code: 3mwm
21132364 L.F.Ferraz, L.C.Verde, R.Vicentini, A.P.Felício, M.L.Ribeiro, F.Alexandrino, M.T.Novo, O.Garcia, D.J.Rigden, and L.M.Ottoboni (2011).
Ferric iron uptake genes are differentially expressed in the presence of copper sulfides in Acidithiobacillus ferrooxidans strain LR.
  Antonie Van Leeuwenhoek, 99, 609-617.  
21338516 N.Vajrala, L.A.Sayavedra-Soto, P.J.Bottomley, and D.J.Arp (2011).
Role of a Fur homolog in iron metabolism in Nitrosomonas europaea.
  BMC Microbiol, 11, 37.  
20442958 D.Osman, and J.S.Cavet (2010).
Bacterial metal-sensing proteins exemplified by ArsR-SmtB family repressors.
  Nat Prod Rep, 27, 668-680.  
20437149 H.L.Pedersen, R.Ahmad, E.K.Riise, H.K.Leiros, S.Hauglid, S.Espelid, B.O.Brandsdal, I.Leiros, N.P.Willassen, and P.Haugen (2010).
Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida).
  J Microbiol, 48, 174-183.  
20562310 R.Uebe, B.Voigt, T.Schweder, D.Albrecht, E.Katzmann, C.Lang, L.Böttger, B.Matzanke, and D.Schüler (2010).
Deletion of a fur-like gene affects iron homeostasis and magnetosome formation in Magnetospirillum gryphiswaldense.
  J Bacteriol, 192, 4192-4204.  
20571957 S.Miles, B.M.Carpenter, H.Gancz, and D.S.Merrell (2010).
Helicobacter pylori apo-Fur regulation appears unconserved across species.
  J Microbiol, 48, 378-386.  
20237769 T.Jittawuttipoka, R.Sallabhan, P.Vattanaviboon, M.Fuangthong, and S.Mongkolsuk (2010).
Mutations of ferric uptake regulator (fur) impair iron homeostasis, growth, oxidative stress survival, and virulence of Xanthomonas campestris pv. campestris.
  Arch Microbiol, 192, 331-339.  
  20428459 B.J.Gaffney (2009).
EPR of Mononuclear Non-Heme Iron Proteins.
  Biol Magn Reson, 28, 233-268.  
19364842 B.M.Carpenter, J.M.Whitmire, and D.S.Merrell (2009).
This is not your mother's repressor: the complex role of fur in pathogenesis.
  Infect Immun, 77, 2590-2601.  
19508286 D.P.Giedroc (2009).
Hydrogen peroxide sensing in Bacillus subtilis: it is all about the (metallo)regulator.
  Mol Microbiol, 73, 1-4.  
19487727 G.A.Somerville, and R.A.Proctor (2009).
At the crossroads of bacterial metabolism and virulence factor synthesis in Staphylococci.
  Microbiol Mol Biol Rev, 73, 233-248.  
19940381 K.Sun, S.Cheng, F.Wang, and L.Sun (2009).
Domain analysis of the Edwardsiella tarda ferric uptake regulator.
  J Gen Appl Microbiol, 55, 351-358.  
19508285 L.Jacquamet, D.A.Traoré, J.L.Ferrer, O.Proux, D.Testemale, J.L.Hazemann, E.Nazarenko, A.El Ghazouani, C.Caux-Thang, V.Duarte, and J.M.Latour (2009).
Structural characterization of the active form of PerR: insights into the metal-induced activation of PerR and Fur proteins for DNA binding.
  Mol Microbiol, 73, 20-31.
PDB code: 3f8n
19400801 M.A.Sheikh, and G.L.Taylor (2009).
Crystal structure of the Vibrio cholerae ferric uptake regulator (Fur) reveals insights into metal co-ordination.
  Mol Microbiol, 72, 1208-1220.
PDB code: 2w57
19772347 M.Sandy, and A.Butler (2009).
Microbial iron acquisition: marine and terrestrial siderophores.
  Chem Rev, 109, 4580-4595.  
19604474 N.Huang, J.De Ingeniis, L.Galeazzi, C.Mancini, Y.D.Korostelev, A.B.Rakhmaninova, M.S.Gelfand, D.A.Rodionov, N.Raffaelli, and H.Zhang (2009).
Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism.
  Structure, 17, 939-951.
PDB codes: 3gz5 3gz6 3gz8
18831042 R.Ahmad, B.O.Brandsdal, I.Michaud-Soret, and N.P.Willassen (2009).
Ferric uptake regulator protein: binding free energy calculations and per-residue free energy decomposition.
  Proteins, 75, 373-386.  
19319388 S.C.Wang, A.V.Dias, and D.B.Zamble (2009).
The "metallo-specific" response of proteins: a perspective based on the Escherichia coli transcriptional regulator NikR.
  Dalton Trans, (), 2459-2466.  
19023664 S.Jabour, and M.Y.Hamed (2009).
Binding of the Zn(2+) ion to ferric uptake regulation protein from E. coli and the competition with Fe(2+) binding: a molecular modeling study of the effect on DNA binding and conformational changes of Fur.
  J Comput Aided Mol Des, 23, 199-208.  
19093075 S.K.Small, S.Puri, and M.R.O'Brian (2009).
Heme-dependent metalloregulation by the iron response regulator (Irr) protein in Rhizobium and other Alpha-proteobacteria.
  Biometals, 22, 89-97.  
19336416 Y.J.An, B.E.Ahn, A.R.Han, H.M.Kim, K.M.Chung, J.H.Shin, Y.B.Cho, J.H.Roe, and S.S.Cha (2009).
Structural basis for the specialization of Nur, a nickel-specific Fur homolog, in metal sensing and DNA recognition.
  Nucleic Acids Res, 37, 3442-3451.
PDB code: 3eyy
19788177 Z.Ma, F.E.Jacobsen, and D.P.Giedroc (2009).
Coordination chemistry of bacterial metal transport and sensing.
  Chem Rev, 109, 4644-4681.  
18972503 A.Mijovilovich (2008).
XANES study of the carboxylate binding mode in two pterin hydroxylases.
  Chem Biodivers, 5, 2131-2139.  
19169435 D.Lucarelli, M.L.Vasil, W.Meyer-Klaucke, and E.Pohl (2008).
The Metal-Dependent Regulators FurA and FurB from Mycobacterium Tuberculosis.
  Int J Mol Sci, 9, 1548-1560.  
18316381 H.L.Briggs, N.Pul, R.Seshadri, M.J.Wilson, C.Tersteeg, K.E.Russell-Lodrigue, M.Andoh, A.J.Bäumler, and J.E.Samuel (2008).
Limited role for iron regulation in Coxiella burnetii pathogenesis.
  Infect Immun, 76, 2189-2201.  
18058194 J.D.Awaya, and J.L.Dubois (2008).
Identification, isolation, and analysis of a gene cluster involved in iron acquisition by Pseudomonas mendocina ymp.
  Biometals, 21, 353-366.  
19107396 K.Sun, S.Cheng, M.Zhang, F.Wang, and L.Sun (2008).
Cys-92, Cys-95, and the C-terminal 12 residues of the Vibrio harveyi ferric uptake regulator (Fur) are functionally inessential.
  J Microbiol, 46, 670-680.  
18400778 L.van Oeffelen, P.Cornelis, W.Van Delm, F.De Ridder, B.De Moor, and Y.Moreau (2008).
Detecting cis-regulatory binding sites for cooperatively binding proteins.
  Nucleic Acids Res, 36, e46.  
18723622 Y.Feng, M.Li, H.Zhang, B.Zheng, H.Han, C.Wang, J.Yan, J.Tang, and G.F.Gao (2008).
Functional definition and global regulation of Zur, a zinc uptake regulator in a Streptococcus suis serotype 2 strain causing streptococcal toxic shock syndrome.
  J Bacteriol, 190, 7567-7578.  
  18259067 Y.J.An, B.E.Ahn, J.H.Roe, and S.S.Cha (2008).
Crystallization and preliminary X-ray crystallographic analyses of Nur, a nickel-responsive transcription regulator from Streptomyces coelicolor.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 64, 130-132.  
18320590 Z.Liu, J.T.Guo, T.Li, and Y.Xu (2008).
Structure-based prediction of transcription factor binding sites using a protein-DNA docking approach.
  Proteins, 72, 1114-1124.  
17120142 D.Koch, D.H.Nies, and G.Grass (2007).
The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis.
  Biometals, 20, 759-771.  
17213192 D.Lucarelli, S.Russo, E.Garman, A.Milano, W.Meyer-Klaucke, and E.Pohl (2007).
Crystal structure and function of the zinc uptake regulator FurB from Mycobacterium tuberculosis.
  J Biol Chem, 282, 9914-9922.
PDB code: 2o03
17637984 D.P.Giedroc, and A.I.Arunkumar (2007).
Metal sensor proteins: nature's metalloregulated allosteric switches.
  Dalton Trans, (), 3107-3120.  
18205608 H.Yijun, Z.Weijia, J.Wei, R.Chengbo, and L.Ying (2007).
Disruption of a fur-like gene inhibits magnetosome formation in Magnetospirillum gryphiswaldense MSR-1.
  Biochemistry (Mosc), 72, 1247-1253.  
17416659 J.H.Shin, S.Y.Oh, S.J.Kim, and J.H.Roe (2007).
The zinc-responsive regulator Zur controls a zinc uptake system and some ribosomal proteins in Streptomyces coelicolor A3(2).
  J Bacteriol, 189, 4070-4077.  
17216355 J.W.Lee, and J.D.Helmann (2007).
Functional specialization within the Fur family of metalloregulators.
  Biometals, 20, 485-499.  
17186376 M.L.Vasil (2007).
How we learnt about iron acquisition in Pseudomonas aeruginosa: a series of very fortunate events.
  Biometals, 20, 587-601.  
17804665 M.Miethke, and M.A.Marahiel (2007).
Siderophore-based iron acquisition and pathogen control.
  Microbiol Mol Biol Rev, 71, 413-451.  
17109885 T.Kawamura, L.U.Le, H.Zhou, and F.W.Dahlquist (2007).
Solution structure of Escherichia coli PapI, a key regulator of the pap pili phase variation.
  J Mol Biol, 365, 1130-1142.
PDB code: 2htj
17921503 Z.Chen, K.A.Lewis, R.K.Shultzaberger, I.G.Lyakhov, M.Zheng, B.Doan, G.Storz, and T.D.Schneider (2007).
Discovery of Fur binding site clusters in Escherichia coli by information theory models.
  Nucleic Acids Res, 35, 6762-6777.  
16553888 B.E.Ahn, J.Cha, E.J.Lee, A.R.Han, C.J.Thompson, and J.H.Roe (2006).
Nur, a nickel-responsive regulator of the Fur family, regulates superoxide dismutases and nickel transport in Streptomyces coelicolor.
  Mol Microbiol, 59, 1848-1858.  
17173478 D.A.Rodionov, M.S.Gelfand, J.D.Todd, A.R.Curson, and A.W.Johnston (2006).
Computational reconstruction of iron- and manganese-responsive transcriptional networks in alpha-proteobacteria.
  PLoS Comput Biol, 2, e163.  
16925555 D.A.Traoré, A.El Ghazouani, S.Ilango, J.Dupuy, L.Jacquamet, J.L.Ferrer, C.Caux-Thang, V.Duarte, and J.M.Latour (2006).
Crystal structure of the apo-PerR-Zn protein from Bacillus subtilis.
  Mol Microbiol, 61, 1211-1219.
PDB code: 2fe3
16630248 D.Zhou, L.Qin, Y.Han, J.Qiu, Z.Chen, B.Li, Y.Song, J.Wang, Z.Guo, J.Zhai, Z.Du, X.Wang, and R.Yang (2006).
Global analysis of iron assimilation and fur regulation in Yersinia pestis.
  FEMS Microbiol Lett, 258, 9.  
16774589 G.Rudolph, H.Hennecke, and H.M.Fischer (2006).
Beyond the Fur paradigm: iron-controlled gene expression in rhizobia.
  FEMS Microbiol Rev, 30, 631-648.  
16980464 H.Louvel, S.Bommezzadri, N.Zidane, C.Boursaux-Eude, S.Creno, A.Magnier, Z.Rouy, C.Médigue, I.Saint Girons, C.Bouchier, and M.Picardeau (2006).
Comparative and functional genomic analyses of iron transport and regulation in Leptospira spp.
  J Bacteriol, 188, 7893-7904.  
16799864 J.A.Hernández, S.López-Gomollón, A.Muro-Pastor, A.Valladares, M.T.Bes, M.L.Peleato, and M.F.Fillat (2006).
Interaction of FurA from Anabaena sp. PCC 7120 with DNA: a reducing environment and the presence of Mn(2+) are positive effectors in the binding to isiB and furA promoters.
  Biometals, 19, 259-268.  
16533030 J.I.Kliegman, S.L.Griner, J.D.Helmann, R.G.Brennan, and A.Glasfeld (2006).
Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis.
  Biochemistry, 45, 3493-3505.
PDB codes: 2ev0 2ev5 2ev6 2f5c 2f5d 2f5e 2f5f
16541078 J.W.Lee, and J.D.Helmann (2006).
The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation.
  Nature, 440, 363-367.  
16766519 J.W.Lee, and J.D.Helmann (2006).
Biochemical characterization of the structural Zn2+ site in the Bacillus subtilis peroxide sensor PerR.
  J Biol Chem, 281, 23567-23578.  
16672617 K.Agnoli, C.A.Lowe, K.L.Farmer, S.I.Husnain, and M.S.Thomas (2006).
The ornibactin biosynthesis and transport genes of Burkholderia cenocepacia are regulated by an extracytoplasmic function sigma factor which is a part of the Fur regulon.
  J Bacteriol, 188, 3631-3644.  
16690618 L.Pecqueur, B.D'Autréaux, J.Dupuy, Y.Nicolet, L.Jacquamet, B.Brutscher, I.Michaud-Soret, and B.Bersch (2006).
Structural changes of Escherichia coli ferric uptake regulator during metal-dependent dimerization and activation explored by NMR and X-ray crystallography.
  J Biol Chem, 281, 21286-21295.
PDB code: 2fu4
15802251 C.M.Moore, and J.D.Helmann (2005).
Metal ion homeostasis in Bacillus subtilis.
  Curr Opin Microbiol, 8, 188-195.  
15601721 D.Parker, R.M.Kennan, G.S.Myers, I.T.Paulsen, and J.I.Rood (2005).
Identification of a Dichelobacter nodosus ferric uptake regulator and determination of its regulatory targets.
  J Bacteriol, 187, 366-375.  
15549269 G.Grass, M.Otto, B.Fricke, C.J.Haney, C.Rensing, D.H.Nies, and D.Munkelt (2005).
FieF (YiiP) from Escherichia coli mediates decreased cellular accumulation of iron and relieves iron stress.
  Arch Microbiol, 183, 9.  
15616356 I.Ascone, R.Fourme, S.Hasnain, and K.Hodgson (2005).
Metallogenomics and biological X-ray absorption spectroscopy.
  J Synchrotron Radiat, 12, 1-3.  
16169981 J.A.Hernández, J.Meier, F.N.Barrera, O.R.de los Paños, E.Hurtado-Gómez, M.T.Bes, M.F.Fillat, M.L.Peleato, C.N.Cavasotto, and J.L.Neira (2005).
The conformational stability and thermodynamics of Fur A (ferric uptake regulator) from Anabaena sp. PCC 7119.
  Biophys J, 89, 4188-4200.  
16158234 M.A.Pennella, and D.P.Giedroc (2005).
Structural determinants of metal selectivity in prokaryotic metal-responsive transcriptional regulators.
  Biometals, 18, 413-428.  
16210314 M.Doucleff, L.T.Malak, J.G.Pelton, and D.E.Wemmer (2005).
The C-terminal RpoN domain of sigma54 forms an unpredicted helix-turn-helix motif similar to domains of sigma70.
  J Biol Chem, 280, 41530-41536.
PDB code: 2ahq
16199555 R.J.Kadner (2005).
Regulation by iron: RNA rules the rust.
  J Bacteriol, 187, 6870-6873.  
15652979 T.Olczak, W.Simpson, X.Liu, and C.A.Genco (2005).
Iron and heme utilization in Porphyromonas gingivalis.
  FEMS Microbiol Rev, 29, 119-144.  
15487950 C.Wandersman, and P.Delepelaire (2004).
Bacterial iron sources: from siderophores to hemophores.
  Annu Rev Microbiol, 58, 611-647.  
15251208 J.A.Hernández, S.López-Gomollón, M.T.Bes, M.F.Fillat, and M.L.Peleato (2004).
Three fur homologues from Anabaena sp. PCC7120: exploring reciprocal protein-promoter recognition.
  FEMS Microbiol Lett, 236, 275-282.  
15554974 J.Seshu, J.A.Boylan, J.A.Hyde, K.L.Swingle, F.C.Gherardini, and J.T.Skare (2004).
A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi.
  Mol Microbiol, 54, 1352-1363.  
15375125 L.I.Katona, R.Tokarz, C.J.Kuhlow, J.Benach, and J.L.Benach (2004).
The fur homologue in Borrelia burgdorferi.
  J Bacteriol, 186, 6443-6456.  
15210934 P.J.Wilderman, N.A.Sowa, D.J.FitzGerald, P.C.FitzGerald, S.Gottesman, U.A.Ochsner, and M.L.Vasil (2004).
Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis.
  Proc Natl Acad Sci U S A, 101, 9792-9797.  
15240318 R.Platero, L.Peixoto, M.R.O'Brian, and E.Fabiano (2004).
Fur is involved in manganese-dependent regulation of mntA (sitA) expression in Sinorhizobium meliloti.
  Appl Environ Microbiol, 70, 4349-4355.  
14960585 T.Liu, S.Nakashima, K.Hirose, M.Shibasaka, M.Katsuhara, B.Ezaki, D.P.Giedroc, and K.Kasamo (2004).
A novel cyanobacterial SmtB/ArsR family repressor regulates the expression of a CPx-ATPase and a metallothionein in response to both Cu(I)/Ag(I) and Zn(II)/Cd(II).
  J Biol Chem, 279, 17810-17818.  
15576789 X.F.Wan, N.C.Verberkmoes, L.A.McCue, D.Stanek, H.Connelly, L.J.Hauser, L.Wu, X.Liu, T.Yan, A.Leaphart, R.L.Hettich, J.Zhou, and D.K.Thompson (2004).
Transcriptomic and proteomic characterization of the Fur modulon in the metal-reducing bacterium Shewanella oneidensis.
  J Bacteriol, 186, 8385-8400.  
15148310 Y.E.Friedman, and M.R.O'Brian (2004).
The ferric uptake regulator (Fur) protein from Bradyrhizobium japonicum is an iron-responsive transcriptional repressor in vitro.
  J Biol Chem, 279, 32100-32105.  
12847518 A.Glasfeld, E.Guedon, J.D.Helmann, and R.G.Brennan (2003).
Structure of the manganese-bound manganese transport regulator of Bacillus subtilis.
  Nat Struct Biol, 10, 652-657.
PDB codes: 1on1 1on2
14617647 C.A.Kunkle, and M.P.Schmitt (2003).
Analysis of the Corynebacterium diphtheriae DtxR regulon: identification of a putative siderophore synthesis and transport system that is similar to the Yersinia high-pathogenicity island-encoded yersiniabactin synthesis and uptake system.
  J Bacteriol, 185, 6826-6840.  
14622419 I.Delany, G.Spohn, R.Rappuoli, and V.Scarlato (2003).
An anti-repression Fur operator upstream of the promoter is required for iron-mediated transcriptional autoregulation in Helicobacter pylori.
  Mol Microbiol, 50, 1329-1338.  
12897000 K.A.Kalivoda, S.M.Steenbergen, E.R.Vimr, and J.Plumbridge (2003).
Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli.
  J Bacteriol, 185, 4806-4815.  
14563870 M.Fuangthong, and J.D.Helmann (2003).
Recognition of DNA by three ferric uptake regulator (Fur) homologs in Bacillus subtilis.
  J Bacteriol, 185, 6348-6357.  
12829269 S.C.Andrews, A.K.Robinson, and F.Rodríguez-Quiñones (2003).
Bacterial iron homeostasis.
  FEMS Microbiol Rev, 27, 215-237.  
12881516 Y.E.Friedman, and M.R.O'Brian (2003).
A novel DNA-binding site for the ferric uptake regulator (Fur) protein from Bradyrhizobium japonicum.
  J Biol Chem, 278, 38395-38401.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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