PDBsum entry 1iiu

Transport protein

PDB id: 1iiu

Contents

Protein chain

174 a.a. *

Ligands

RTL

Metals

_CD

Waters ×95

* Residue conservation analysis

PDB id:

1iiu

Name:

Transport protein

Title:

Chicken plasma retinol-binding protein (rbp)

Structure:

Plasma retinol-binding protein. Chain: a. Synonym: prbp

Source:

Gallus gallus. Chicken. Organism_taxid: 9031

Resolution:

2.50Å R-factor: 0.211 R-free: 0.266

Authors:

G.Zanotti,V.Calderone,R.Berni

Key ref:

G.Zanotti et al. (2001). Structure of chicken plasma retinol-binding protein. Biochim Biophys Acta, 1550, 64-69. PubMed id: 11738088 DOI: 10.1016/S0167-4838(01)00268-0

Date:

24-Apr-01 Release date: 16-Jan-02

Protein chain

P41263  (RET4_CHICK) -  Retinol-binding protein 4 from Gallus gallus

Seq: 196 a.a.

Struc: 174 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

DOI no: 10.1016/S0167-4838(01)00268-0

Biochim Biophys Acta 1550:64-69 (2001)

PubMed id: 11738088

Structure of chicken plasma retinol-binding protein.

G.Zanotti, V.Calderone, M.Beda, G.Malpeli, C.Folli, R.Berni.

ABSTRACT

The crystal structure of the specific carrier of retinol (retinol-binding protein, RBP) purified from chicken plasma has been determined (space group P2(1)2(1)2(1), with a=46.06(5) A, b=53.56(6) A, c=73.41(8) A, and one protein molecule in the asymmetric unit). Despite being obtained from a species phylogenetically distant from mammals, chicken holoRBP has an overall structure that closely resembles the previously determined structures of mammalian holoRBPs. The lack in chicken RBP of eight carboxy-terminal amino acid residues characteristic of mammalian RBPs does not significantly affect the protein structure. A distinctive feature of the avian protein is a better definition of the loop 63-67, close to the opening of the beta-barrel cavity accommodating the retinol molecule, which is rather disordered in the structures of mammalian RBPs.