PDBsum entry 1if4

Lyase

PDB id: 1if4

Contents

Protein chain

258 a.a. *

Ligands

FBS

Metals

_ZN

_HG

Waters ×60

* Residue conservation analysis

PDB id:

1if4

Name:

Lyase

Title:

Carbonic anhydrase ii complexed with 4-fluorobenzenesulfonamide

Structure:

Carbonic anhydrase ii. Chain: a. Synonym: carbonate dehydratase ii. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.93Å R-factor: 0.219 R-free: 0.296

Authors:

C.-Y.Kim,D.W.Christianson

Key ref:

C.-Y.Kim and d.w.christianson Binding of fluorine substituted benzenesulfonamides to carbonic anhydrase ii. To be published, .

Date:

12-Apr-01 Release date: 02-May-01

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 258 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site