 |
PDBsum entry 1glu
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Transcription/DNA
|
PDB id
|
|
|
|
1glu
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
Nature
352:497-505
(1991)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA.
|
|
B.F.Luisi,
W.X.Xu,
Z.Otwinowski,
L.P.Freedman,
K.R.Yamamoto,
P.B.Sigler.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
Two crystal structures of the glucocorticoid receptor DNA-binding domain
complexed with DNA are reported. The domain has a globular fold which contains
two Zn-nucleated substructures of distinct conformation and function. When it
binds DNA, the domain dimerizes, placing the subunits in adjacent major grooves.
In one complex, the DNA has the symmetrical consensus target sequence; in the
second, the central spacing between the target's half-sites is larger by one
base pair. This results in one subunit interacting specifically with the
consensus target half-site and the other nonspecifically with a noncognate
element. The DNA-induced dimer fixes the separation of the subunits' recognition
surfaces so that the spacing between the half-sites becomes a critical feature
of the target sequence's identity.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
W.H.Hudson,
C.Youn,
and
E.A.Ortlund
(2013).
The structural basis of direct glucocorticoid-mediated transrepression.
|
| |
Nat Struct Mol Biol,
20,
53-58.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.K.Hinz,
Y.Wang,
and
M.J.Smerdon
(2010).
Base excision repair in a glucocorticoid response element: effect of glucocorticoid receptor binding.
|
| |
J Biol Chem,
285,
28683-28690.
|
|
|
|
|
|
|
D.M.Chenoweth,
and
P.B.Dervan
(2010).
Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding.
|
| |
J Am Chem Soc,
132,
14521-14529.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
I.E.Sánchez,
D.U.Ferreiro,
M.Dellarole,
and
G.de Prat-Gay
(2010).
Experimental snapshots of a protein-DNA binding landscape.
|
| |
Proc Natl Acad Sci U S A,
107,
7751-7756.
|
|
|
|
|
|
|
J.D.Ballin,
J.P.Prevas,
C.R.Ross,
E.A.Toth,
G.M.Wilson,
and
M.T.Record
(2010).
Contributions of the histidine side chain and the N-terminal alpha-amino group to the binding thermodynamics of oligopeptides to nucleic acids as a function of pH.
|
| |
Biochemistry,
49,
2018-2030.
|
|
|
|
|
|
|
J.M.D'Antonio,
D.J.Vander Griend,
L.Antony,
G.Ndikuyeze,
S.L.Dalrymple,
S.Koochekpour,
and
J.T.Isaacs
(2010).
Loss of androgen receptor-dependent growth suppression by prostate cancer cells can occur independently from acquiring oncogenic addiction to androgen receptor signaling.
|
| |
PLoS One,
5,
e11475.
|
|
|
|
|
|
|
L.E.Shipp,
J.V.Lee,
C.Y.Yu,
M.Pufall,
P.Zhang,
D.K.Scott,
and
J.C.Wang
(2010).
Transcriptional regulation of human dual specificity protein phosphatase 1 (DUSP1) gene by glucocorticoids.
|
| |
PLoS One,
5,
e13754.
|
|
|
|
|
|
|
R.Newton,
R.Leigh,
and
M.A.Giembycz
(2010).
Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases.
|
| |
Pharmacol Ther,
125,
286-327.
|
|
|
|
|
|
|
R.Rohs,
X.Jin,
S.M.West,
R.Joshi,
B.Honig,
and
R.S.Mann
(2010).
Origins of specificity in protein-DNA recognition.
|
| |
Annu Rev Biochem,
79,
233-269.
|
|
|
|
|
|
|
T.Kino,
D.E.Hurt,
T.Ichijo,
N.Nader,
and
G.P.Chrousos
(2010).
Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor.
|
| |
Sci Signal,
3,
ra8.
|
|
|
|
|
|
|
Y.Xing,
X.Fan,
and
D.Ying
(2010).
Liver X receptor agonist treatment promotes the migration of granule neurons during cerebellar development.
|
| |
J Neurochem,
115,
1486-1494.
|
|
|
|
|
|
|
A.A.George,
R.L.Schiltz,
and
G.L.Hager
(2009).
Dynamic access of the glucocorticoid receptor to response elements in chromatin.
|
| |
Int J Biochem Cell Biol,
41,
214-224.
|
|
|
|
|
|
|
L.R.Stow,
M.L.Gumz,
I.J.Lynch,
M.M.Greenlee,
A.Rudin,
B.D.Cain,
and
C.S.Wingo
(2009).
Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1).
|
| |
J Biol Chem,
284,
30087-30096.
|
|
|
|
|
|
|
M.S.Flaherty,
J.Zavadil,
L.A.Ekas,
and
E.A.Bach
(2009).
Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway.
|
| |
Dev Dyn,
238,
2235-2253.
|
|
|
|
|
|
|
S.H.Meijsing,
M.A.Pufall,
A.Y.So,
D.L.Bates,
L.Chen,
and
K.R.Yamamoto
(2009).
DNA binding site sequence directs glucocorticoid receptor structure and activity.
|
| |
Science,
324,
407-410.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.K.Koliwad,
T.Kuo,
L.E.Shipp,
N.E.Gray,
F.Backhed,
A.Y.So,
R.V.Farese,
and
J.C.Wang
(2009).
Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
|
| |
J Biol Chem,
284,
25593-25601.
|
|
|
|
|
|
|
A.Morani,
M.Warner,
and
J.A.Gustafsson
(2008).
Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues.
|
| |
J Intern Med,
264,
128-142.
|
|
|
|
|
|
|
A.Y.So,
S.B.Cooper,
B.J.Feldman,
M.Manuchehri,
and
K.R.Yamamoto
(2008).
Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes.
|
| |
Proc Natl Acad Sci U S A,
105,
5745-5749.
|
|
|
|
|
|
|
F.Claessens,
S.Denayer,
N.Van Tilborgh,
S.Kerkhofs,
C.Helsen,
and
A.Haelens
(2008).
Diverse roles of androgen receptor (AR) domains in AR-mediated signaling.
|
| |
Nucl Recept Signal,
6,
e008.
|
|
|
|
|
|
|
H.Reinke,
C.Saini,
F.Fleury-Olela,
C.Dibner,
I.J.Benjamin,
and
U.Schibler
(2008).
Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor.
|
| |
Genes Dev,
22,
331-345.
|
|
|
|
|
|
|
L.A.Ponguta,
C.W.Gregory,
F.S.French,
and
E.M.Wilson
(2008).
Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer.
|
| |
J Biol Chem,
283,
20989-21001.
|
|
|
|
|
|
|
R.Kumar,
and
W.J.Calhoun
(2008).
Differential regulation of the transcriptional activity of the glucocorticoid receptor through site-specific phosphorylation.
|
| |
Biologics,
2,
845-854.
|
|
|
|
|
|
|
S.R.Holmstrom,
S.Chupreta,
A.Y.So,
and
J.A.Iñiguez-Lluhí
(2008).
SUMO-mediated inhibition of glucocorticoid receptor synergistic activity depends on stable assembly at the promoter but not on DAXX.
|
| |
Mol Endocrinol,
22,
2061-2075.
|
|
|
|
|
|
|
A.Carrigan,
R.F.Walther,
H.A.Salem,
D.Wu,
E.Atlas,
Y.A.Lefebvre,
and
R.J.Haché
(2007).
An active nuclear retention signal in the glucocorticoid receptor functions as a strong inducer of transcriptional activation.
|
| |
J Biol Chem,
282,
10963-10971.
|
|
|
|
|
|
|
A.Marabotti,
G.Colonna,
and
A.Facchiano
(2007).
New computational strategy to analyze the interactions of ERalpha and ERbeta with different ERE sequences.
|
| |
J Comput Chem,
28,
1031-1041.
|
|
|
|
|
|
|
A.Y.So,
C.Chaivorapol,
E.C.Bolton,
H.Li,
and
K.R.Yamamoto
(2007).
Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor.
|
| |
PLoS Genet,
3,
e94.
|
|
|
|
|
|
|
D.L.Bain,
A.F.Heneghan,
K.D.Connaghan-Jones,
and
M.T.Miura
(2007).
Nuclear receptor structure: implications for function.
|
| |
Annu Rev Physiol,
69,
201-220.
|
|
|
|
|
|
|
D.Nguyen,
M.Bail,
G.Pesant,
V.N.Dupont,
E.Rouault,
J.Deschênes,
W.Rocha,
G.Melançon,
S.V.Steinberg,
and
S.Mader
(2007).
Rational design of an estrogen receptor mutant with altered DNA-binding specificity.
|
| |
Nucleic Acids Res,
35,
3465-3477.
|
|
|
|
|
|
|
K.Schauwaers,
K.De Gendt,
P.T.Saunders,
N.Atanassova,
A.Haelens,
L.Callewaert,
U.Moehren,
J.V.Swinnen,
G.Verhoeven,
G.Verrijdt,
and
F.Claessens
(2007).
Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model.
|
| |
Proc Natl Acad Sci U S A,
104,
4961-4966.
|
|
|
|
|
|
|
L.Pujo,
J.Fagart,
F.Gary,
D.T.Papadimitriou,
A.Claës,
X.Jeunemaître,
and
M.C.Zennaro
(2007).
Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism.
|
| |
Hum Mutat,
28,
33-40.
|
|
|
|
|
|
|
M.M.McGrane
(2007).
Vitamin A regulation of gene expression: molecular mechanism of a prototype gene.
|
| |
J Nutr Biochem,
18,
497-508.
|
|
|
|
|
|
|
N.G.Nickols,
and
P.B.Dervan
(2007).
Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide.
|
| |
Proc Natl Acad Sci U S A,
104,
10418-10423.
|
|
|
|
|
|
|
R.P.Metpally,
R.Vigneshwar,
and
R.Sowdhamini
(2007).
Genome inventory and analysis of nuclear hormone receptors in Tetraodon nigroviridis.
|
| |
J Biosci,
32,
43-50.
|
|
|
|
|
|
|
S.A.Townson,
J.C.Samuelson,
Y.Bao,
S.Y.Xu,
and
A.K.Aggarwal
(2007).
BstYI bound to noncognate DNA reveals a "hemispecific" complex: implications for DNA scanning.
|
| |
Structure,
15,
449-459.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
T.Bawa-Khalfe,
J.Cheng,
Z.Wang,
and
E.T.Yeh
(2007).
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
|
| |
J Biol Chem,
282,
37341-37349.
|
|
|
|
|
|
|
A.V.Fedorova,
I.S.Chan,
and
J.A.Shin
(2006).
The GCN4 bZIP can bind to noncognate gene regulatory sequences.
|
| |
Biochim Biophys Acta,
1764,
1252-1259.
|
|
|
|
|
|
|
C.Xu,
M.E.Call,
and
K.W.Wucherpfennig
(2006).
A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.
|
| |
J Biol Chem,
281,
36977-36984.
|
|
|
|
|
|
|
I.H.Chan,
and
M.L.Privalsky
(2006).
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs.
|
| |
Oncogene,
25,
3576-3588.
|
|
|
|
|
|
|
J.T.Moore,
J.L.Collins,
and
K.H.Pearce
(2006).
The nuclear receptor superfamily and drug discovery.
|
| |
ChemMedChem,
1,
504-523.
|
|
|
|
|
|
|
M.D.Sam,
M.A.Abbani,
D.Cascio,
R.C.Johnson,
and
R.T.Clubb
(2006).
Crystallization, dehydration and preliminary X-ray analysis of excisionase (Xis) proteins cooperatively bound to DNA.
|
| |
Acta Crystallogr Sect F Struct Biol Cryst Commun,
62,
825-828.
|
|
|
|
|
|
|
M.J.Herold,
K.G.McPherson,
and
H.M.Reichardt
(2006).
Glucocorticoids in T cell apoptosis and function.
|
| |
Cell Mol Life Sci,
63,
60-72.
|
|
|
|
|
|
|
S.C.Roemer,
D.C.Donham,
L.Sherman,
V.H.Pon,
D.P.Edwards,
and
M.E.Churchill
(2006).
Structure of the progesterone receptor-deoxyribonucleic acid complex: novel interactions required for binding to half-site response elements.
|
| |
Mol Endocrinol,
20,
3042-3052.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Y.Chen,
T.J.Nickola,
N.L.DiFronzo,
A.M.Colberg-Poley,
and
M.C.Rose
(2006).
Dexamethasone-mediated repression of MUC5AC gene expression in human lung epithelial cells.
|
| |
Am J Respir Cell Mol Biol,
34,
338-347.
|
|
|
|
|
|
|
Z.Orbak
(2006).
Glucocorticoid resistance.
|
| |
Biochemistry (Mosc),
71,
1073-1081.
|
|
|
|
|
|
|
A.M.Zimeri,
O.P.Dhankher,
B.McCaig,
and
R.B.Meagher
(2005).
The plant MT1 metallothioneins are stabilized by binding cadmiums and are required for cadmium tolerance and accumulation.
|
| |
Plant Mol Biol,
58,
839-855.
|
|
|
|
|
|
|
A.Sarai,
and
H.Kono
(2005).
Protein-DNA recognition patterns and predictions.
|
| |
Annu Rev Biophys Biomol Struct,
34,
379-398.
|
|
|
|
|
|
|
C.He,
J.C.Hus,
L.J.Sun,
P.Zhou,
D.P.Norman,
V.Dötsch,
H.Wei,
J.D.Gross,
W.S.Lane,
G.Wagner,
and
G.L.Verdine
(2005).
A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada.
|
| |
Mol Cell,
20,
117-129.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.E.Donald,
and
E.I.Shakhnovich
(2005).
Predicting specificity-determining residues in two large eukaryotic transcription factor families.
|
| |
Nucleic Acids Res,
33,
4455-4465.
|
|
|
|
|
|
|
M.Fuxreiter,
M.Mezei,
I.Simon,
and
R.Osman
(2005).
Interfacial water as a "hydration fingerprint" in the noncognate complex of BamHI.
|
| |
Biophys J,
89,
903-911.
|
|
|
|
|
|
|
Y.Shostak,
and
K.R.Yamamoto
(2005).
Overlapping but separable determinants of DNA binding and nuclear localization map to the C-terminal end of the Caenorhabditis elegans DAF-12 DNA binding domain.
|
| |
J Biol Chem,
280,
6554-6560.
|
|
|
|
|
|
|
B.M.Necela,
and
J.A.Cidlowski
(2004).
A single amino acid change in the first zinc finger of the DNA binding domain of the glucocorticoid receptor regulates differential promoter selectivity.
|
| |
J Biol Chem,
279,
39279-39288.
|
|
|
|
|
|
|
M.Grabacka,
W.Placha,
P.M.Plonka,
S.Pajak,
K.Urbanska,
P.Laidler,
and
A.Slominski
(2004).
Inhibition of melanoma metastases by fenofibrate.
|
| |
Arch Dermatol Res,
296,
54-58.
|
|
|
|
|
|
|
M.Welin,
U.Kosinska,
N.E.Mikkelsen,
C.Carnrot,
C.Zhu,
L.Wang,
S.Eriksson,
B.Munch-Petersen,
and
H.Eklund
(2004).
Structures of thymidine kinase 1 of human and mycoplasmic origin.
|
| |
Proc Natl Acad Sci U S A,
101,
17970-17975.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
N.Z.Lu,
and
J.A.Cidlowski
(2004).
The origin and functions of multiple human glucocorticoid receptor isoforms.
|
| |
Ann N Y Acad Sci,
1024,
102-123.
|
|
|
|
|
|
|
P.L.Shaffer,
A.Jivan,
D.E.Dollins,
F.Claessens,
and
D.T.Gewirth
(2004).
Structural basis of androgen receptor binding to selective androgen response elements.
|
| |
Proc Natl Acad Sci U S A,
101,
4758-4763.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.Kumar,
D.E.Volk,
J.Li,
J.C.Lee,
D.G.Gorenstein,
and
E.B.Thompson
(2004).
TATA box binding protein induces structure in the recombinant glucocorticoid receptor AF1 domain.
|
| |
Proc Natl Acad Sci U S A,
101,
16425-16430.
|
|
|
|
|
|
|
S.Belikov,
C.Astrand,
P.H.Holmqvist,
and
O.Wrange
(2004).
Chromatin-mediated restriction of nuclear factor 1/CTF binding in a repressed and hormone-activated promoter in vivo.
|
| |
Mol Cell Biol,
24,
3036-3047.
|
|
|
|
|
|
|
V.S.Melvin,
C.Harrell,
J.S.Adelman,
W.L.Kraus,
M.Churchill,
and
D.P.Edwards
(2004).
The role of the C-terminal extension (CTE) of the estrogen receptor alpha and beta DNA binding domain in DNA binding and interaction with HMGB.
|
| |
J Biol Chem,
279,
14763-14771.
|
|
|
|
|
|
|
Y.Umemura,
T.Ishiduka,
R.Yamamoto,
and
M.Esaka
(2004).
The Dof domain, a zinc finger DNA-binding domain conserved only in higher plants, truly functions as a Cys2/Cys2 Zn finger domain.
|
| |
Plant J,
37,
741-749.
|
|
|
|
|
|
|
B.M.Necela,
and
J.A.Cidlowski
(2003).
Crystallization of the human glucocorticoid receptor ligand binding domain: a step towards selective glucocorticoids.
|
| |
Trends Pharmacol Sci,
24,
58-61.
|
|
|
|
|
|
|
I.Rogatsky,
J.C.Wang,
M.K.Derynck,
D.F.Nonaka,
D.B.Khodabakhsh,
C.M.Haqq,
B.D.Darimont,
M.J.Garabedian,
and
K.R.Yamamoto
(2003).
Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor.
|
| |
Proc Natl Acad Sci U S A,
100,
13845-13850.
|
|
|
|
|
|
|
J.C.Payne,
B.W.Rous,
A.L.Tenderholt,
and
H.A.Godwin
(2003).
Spectroscopic determination of the binding affinity of zinc to the DNA-binding domains of nuclear hormone receptors.
|
| |
Biochemistry,
42,
14214-14224.
|
|
|
|
|
|
|
J.Sun,
H.Viadiu,
A.K.Aggarwal,
and
H.Weinstein
(2003).
Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex.
|
| |
Biophys J,
84,
3317-3325.
|
|
|
|
|
|
|
M.E.Colosimo,
S.Tran,
and
P.Sengupta
(2003).
The divergent orphan nuclear receptor ODR-7 regulates olfactory neuron gene expression via multiple mechanisms in Caenorhabditis elegans.
|
| |
Genetics,
165,
1779-1791.
|
|
|
|
|
|
|
N.Shibusawa,
A.N.Hollenberg,
and
F.E.Wondisford
(2003).
Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation.
|
| |
J Biol Chem,
278,
732-738.
|
|
|
|
|
|
|
R.Jauch,
G.P.Bourenkov,
H.R.Chung,
H.Urlaub,
U.Reidt,
H.Jäckle,
and
M.C.Wahl
(2003).
The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module.
|
| |
Structure,
11,
1393-1402.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.Devarakonda,
J.M.Harp,
Y.Kim,
A.Ozyhar,
and
F.Rastinejad
(2003).
Structure of the heterodimeric ecdysone receptor DNA-binding complex.
|
| |
EMBO J,
22,
5827-5840.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.G.Kalodimos,
A.M.Bonvin,
R.K.Salinas,
R.Wechselberger,
R.Boelens,
and
R.Kaptein
(2002).
Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain.
|
| |
EMBO J,
21,
2866-2876.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
G.Verrijdt,
K.Schauwaers,
A.Haelens,
W.Rombauts,
and
F.Claessens
(2002).
Functional interplay between two response elements with distinct binding characteristics dictates androgen specificity of the mouse sex-limited protein enhancer.
|
| |
J Biol Chem,
277,
35191-35201.
|
|
|
|
|
|
|
J.Bredenberg,
and
L.Nilsson
(2002).
Conformational states of the glucocorticoid receptor DNA-binding domain from molecular dynamics simulations.
|
| |
Proteins,
49,
24-36.
|
|
|
|
|
|
|
J.Chen,
S.Kaul,
and
S.S.Simons
(2002).
Structure/activity elements of the multifunctional protein, GMEB-1. Characterization of domains relevant for the modulation of glucocorticoid receptor transactivation properties.
|
| |
J Biol Chem,
277,
22053-22062.
|
|
|
|
|
|
|
K.Mitsouras,
B.Wong,
C.Arayata,
R.C.Johnson,
and
M.Carey
(2002).
The DNA architectural protein HMGB1 displays two distinct modes of action that promote enhanceosome assembly.
|
| |
Mol Cell Biol,
22,
4390-4401.
|
|
|
|
|
|
|
P.L.Shaffer,
and
D.T.Gewirth
(2002).
Structural basis of VDR-DNA interactions on direct repeat response elements.
|
| |
EMBO J,
21,
2242-2252.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
P.W.Jurutka,
P.N.MacDonald,
S.Nakajima,
J.C.Hsieh,
P.D.Thompson,
G.K.Whitfield,
M.A.Galligan,
C.A.Haussler,
and
M.R.Haussler
(2002).
Isolation of baculovirus-expressed human vitamin D receptor: DNA responsive element interactions and phosphorylation of the purified receptor.
|
| |
J Cell Biochem,
85,
435-457.
|
|
|
|
|
|
|
R.Sanchez,
D.Nguyen,
W.Rocha,
J.H.White,
and
S.Mader
(2002).
Diversity in the mechanisms of gene regulation by estrogen receptors.
|
| |
Bioessays,
24,
244-254.
|
|
|
|
|
|
|
X.Gao,
D.J.Rowley,
X.Gai,
and
D.F.Voytas
(2002).
Ty5 gag mutations increase retrotransposition and suggest a role for hydrogen bonding in the function of the nucleocapsid zinc finger.
|
| |
J Virol,
76,
3240-3247.
|
|
|
|
|
|
|
Y.S.Ji,
B.H.Johnson,
M.S.Webb,
and
E.B.Thompson
(2002).
Mutational analysis of DBD*--a unique antileukemic gene sequence.
|
| |
Neoplasia,
4,
417-423.
|
|
|
|
|
|
|
F.Rastinejad
(2001).
Retinoid X receptor and its partners in the nuclear receptor family.
|
| |
Curr Opin Struct Biol,
11,
33-38.
|
|
|
|
|
|
|
H.Hauksdóttir,
and
M.L.Privalsky
(2001).
DNA recognition by the aberrant retinoic acid receptors implicated in human acute promyelocytic leukemia.
|
| |
Cell Growth Differ,
12,
85-98.
|
|
|
|
|
|
|
J.G.Savory,
G.G.Préfontaine,
C.Lamprecht,
M.Liao,
R.F.Walther,
Y.A.Lefebvre,
and
R.J.Haché
(2001).
Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces.
|
| |
Mol Cell Biol,
21,
781-793.
|
|
|
|
|
|
|
K.Pettersson,
and
J.A.Gustafsson
(2001).
Role of estrogen receptor beta in estrogen action.
|
| |
Annu Rev Physiol,
63,
165-192.
|
|
|
|
|
|
|
M.Ruiz,
U.Lind,
M.Gåfvels,
G.Eggertsen,
J.Carlstedt-Duke,
L.Nilsson,
M.Holtmann,
P.Stierna,
A.C.Wikström,
and
S.Werner
(2001).
Characterization of two novel mutations in the glucocorticoid receptor gene in patients with primary cortisol resistance.
|
| |
Clin Endocrinol (Oxf),
55,
363-371.
|
|
|
|
|
|
|
M.Wang,
J.S.You,
and
S.H.Lee
(2001).
Role of zinc-finger motif in redox regulation of human replication protein A.
|
| |
Antioxid Redox Signal,
3,
657-669.
|
|
|
|
|
|
|
N.V.Grishin
(2001).
Treble clef finger--a functionally diverse zinc-binding structural motif.
|
| |
Nucleic Acids Res,
29,
1703-1714.
|
|
|
|
|
|
|
O.Littlefield,
and
H.C.Nelson
(2001).
Crystal packing interaction that blocks crystallization of a site-specific DNA binding protein-DNA complex.
|
| |
Proteins,
45,
219-228.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.Khorasanizadeh,
and
F.Rastinejad
(2001).
Nuclear-receptor interactions on DNA-response elements.
|
| |
Trends Biochem Sci,
26,
384-390.
|
|
|
|
|
|
|
S.Plaza,
F.Prince,
J.Jaeger,
U.Kloter,
S.Flister,
C.Benassayag,
D.Cribbs,
and
W.J.Gehring
(2001).
Molecular basis for the inhibition of Drosophila eye development by Antennapedia.
|
| |
EMBO J,
20,
802-811.
|
|
|
|
|
|
|
A.Antebi,
W.H.Yeh,
D.Tait,
E.M.Hedgecock,
and
D.L.Riddle
(2000).
daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans.
|
| |
Genes Dev,
14,
1512-1527.
|
|
|
|
|
|
|
A.Sapone,
J.M.Peters,
S.Sakai,
S.Tomita,
S.S.Papiha,
R.Dai,
F.K.Friedman,
and
F.J.Gonzalez
(2000).
The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.
|
| |
Pharmacogenetics,
10,
321-333.
|
|
|
|
|
|
|
C.Castagné,
H.Terenzi,
M.M.Zakin,
and
M.Delepierre
(2000).
Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*.
|
| |
Biochimie,
82,
739-748.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.B.Defranco
(2000).
Role of molecular chaperones in subnuclear trafficking of glucocorticoid receptors.
|
| |
Kidney Int,
57,
1241-1249.
|
|
|
|
|
|
|
D.J.Segal,
and
C.F.Barbas
(2000).
Design of novel sequence-specific DNA-binding proteins.
|
| |
Curr Opin Chem Biol,
4,
34-39.
|
|
|
|
|
|
|
E.Schoenmakers,
G.Verrijdt,
B.Peeters,
G.Verhoeven,
W.Rombauts,
and
F.Claessens
(2000).
Differences in DNA binding characteristics of the androgen and glucocorticoid receptors can determine hormone-specific responses.
|
| |
J Biol Chem,
275,
12290-12297.
|
|
|
|
|
|
|
F.Rastinejad,
T.Wagner,
Q.Zhao,
and
S.Khorasanizadeh
(2000).
Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.
|
| |
EMBO J,
19,
1045-1054.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.Poukka,
P.Aarnisalo,
H.Santti,
O.A.Jänne,
and
J.J.Palvimo
(2000).
Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms.
|
| |
J Biol Chem,
275,
571-579.
|
|
|
|
|
|
|
I.Anderson,
and
J.Gorski
(2000).
Estrogen receptor alpha interaction with estrogen response element half-sites from the rat prolactin gene.
|
| |
Biochemistry,
39,
3842-3847.
|
|
|
|
|
|
|
J.A.Iñiguez-Lluhí,
and
D.Pearce
(2000).
A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy.
|
| |
Mol Cell Biol,
20,
6040-6050.
|
|
|
|
|
|
|
J.S.You,
M.Wang,
and
S.H.Lee
(2000).
Functional characterization of zinc-finger motif in redox regulation of RPA-ssDNA interaction.
|
| |
Biochemistry,
39,
12953-12958.
|
|
|
|
|
|
|
J.Zhang,
and
M.A.Lazar
(2000).
The mechanism of action of thyroid hormones.
|
| |
Annu Rev Physiol,
62,
439-466.
|
|
|
|
|
|
|
L.M.Lima,
D.Foguel,
and
J.L.Silva
(2000).
DNA tightens the dimeric DNA-binding domain of human papillomavirus E2 protein without changes in volume.
|
| |
Proc Natl Acad Sci U S A,
97,
14289-14294.
|
|
|
|
|
|
|
M.Ruff,
M.Gangloff,
J.M.Wurtz,
and
D.Moras
(2000).
Estrogen receptor transcription and transactivation: Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors.
|
| |
Breast Cancer Res,
2,
353-359.
|
|
|
|
|
|
|
M.Thompson,
and
N.W.Woodbury
(2000).
Fluorescent and photochemical properties of a single zinc finger conjugated to a fluorescent DNA-binding probe.
|
| |
Biochemistry,
39,
4327-4338.
|
|
|
|
|
|
|
N.Radoja,
M.Komine,
S.H.Jho,
M.Blumenberg,
and
M.Tomic-Canic
(2000).
Novel mechanism of steroid action in skin through glucocorticoid receptor monomers.
|
| |
Mol Cell Biol,
20,
4328-4339.
|
|
|
|
|
|
|
P.J.van Tilborg,
M.Czisch,
F.A.Mulder,
G.E.Folkers,
A.M.Bonvin,
M.Nair,
R.Boelens,
and
R.Kaptein
(2000).
Changes in dynamical behavior of the retinoid X receptor DNA-binding domain upon binding to a 14 base-pair DNA half site.
|
| |
Biochemistry,
39,
8747-8757.
|
|
|
|
|
|
|
R.M.Nissen,
and
K.R.Yamamoto
(2000).
The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain.
|
| |
Genes Dev,
14,
2314-2329.
|
|
|
|
|
|
|
R.Mohana-Borges,
A.B.Pacheco,
F.J.Sousa,
D.Foguel,
D.F.Almeida,
and
J.L.Silva
(2000).
LexA repressor forms stable dimers in solution. The role of specific dna in tightening protein-protein interactions.
|
| |
J Biol Chem,
275,
4708-4712.
|
|
|
|
|
|
|
T.Lundbäck,
S.van Den Berg,
and
T.Härd
(2000).
Sequence-specific DNA binding by the glucocorticoid receptor DNA-binding domain is linked to a salt-dependent histidine protonation.
|
| |
Biochemistry,
39,
8909-8916.
|
|
|
|
|
|
|
T.M.Fletcher,
B.W.Ryu,
C.T.Baumann,
B.S.Warren,
G.Fragoso,
S.John,
and
G.L.Hager
(2000).
Structure and dynamic properties of a glucocorticoid receptor-induced chromatin transition.
|
| |
Mol Cell Biol,
20,
6466-6475.
|
|
|
|
|
|
|
B.Xiao,
G.Shi,
X.Chen,
H.Yan,
and
X.Ji
(1999).
Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents.
|
| |
Structure,
7,
489-496.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
C.Huang,
N.Kohno,
H.Inufusa,
K.Kodama,
T.Taki,
and
M.Miyake
(1999).
Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53.
|
| |
Am J Pathol,
155,
955-965.
|
|
|
|
|
|
|
C.M.Falcon,
and
K.S.Matthews
(1999).
Glycine insertion in the hinge region of lactose repressor protein alters DNA binding.
|
| |
J Biol Chem,
274,
30849-30857.
|
|
|
|
|
|
|
C.Wolberger
(1999).
Multiprotein-DNA complexes in transcriptional regulation.
|
| |
Annu Rev Biophys Biomol Struct,
28,
29-56.
|
|
|
|
|
|
|
D.B.DeFranco
(1999).
Regulation of steroid receptor subcellular trafficking.
|
| |
Cell Biochem Biophys,
30,
1.
|
|
|
|
|
|
|
F.H.Allain,
Y.M.Yen,
J.E.Masse,
P.Schultze,
T.Dieckmann,
R.C.Johnson,
and
J.Feigon
(1999).
Solution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence-specific binding.
|
| |
EMBO J,
18,
2563-2579.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
G.Schweizer-Groyer,
N.Jibard,
E.Neau,
D.Fortin,
F.Cadepond,
E.E.Baulieu,
and
A.Groyer
(1999).
The glucocorticoid response element II is functionally homologous in rat and human insulin-like growth factor-binding protein-1 promoters.
|
| |
J Biol Chem,
274,
11679-11686.
|
|
|
|
|
|
|
H.J.Berkovits,
and
J.M.Berg
(1999).
Metal and DNA binding properties of a two-domain fragment of neural zinc finger factor 1, a CCHC-type zinc binding protein.
|
| |
Biochemistry,
38,
16826-16830.
|
|
|
|
|
|
|
H.Kono,
and
A.Sarai
(1999).
Structure-based prediction of DNA target sites by regulatory proteins.
|
| |
Proteins,
35,
114-131.
|
|
|
|
|
|
|
H.Tanaka,
Y.Makino,
K.Okamoto,
T.Iida,
K.Yan,
and
N.Yoshikawa
(1999).
Redox regulation of the glucocorticoid receptor.
|
| |
Antioxid Redox Signal,
1,
403-423.
|
|
|
|
|
|
|
I.Rogatsky,
A.B.Hittelman,
D.Pearce,
and
M.J.Garabedian
(1999).
Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids.
|
| |
Mol Cell Biol,
19,
5036-5049.
|
|
|
|
|
|
|
I.V.Baskakov,
R.Kumar,
G.Srinivasan,
Y.S.Ji,
D.W.Bolen,
and
E.B.Thompson
(1999).
Trimethylamine N-oxide-induced cooperative folding of an intrinsically unfolded transcription-activating fragment of human glucocorticoid receptor.
|
| |
J Biol Chem,
274,
10693-10696.
|
|
|
|
|
|
|
J.F.Schildbach,
A.W.Karzai,
B.E.Raumann,
and
R.T.Sauer
(1999).
Origins of DNA-binding specificity: role of protein contacts with the DNA backbone.
|
| |
Proc Natl Acad Sci U S A,
96,
811-817.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.P.Charles,
T.Shinoda,
and
Y.Chinzei
(1999).
Characterization and DNA-binding properties of GRF, a novel monomeric binding orphan receptor related to GCNF and betaFTZ-F1.
|
| |
Eur J Biochem,
266,
181-190.
|
|
|
|
|
|
|
J.S.Park,
M.Wang,
S.J.Park,
and
S.H.Lee
(1999).
Zinc finger of replication protein A, a non-DNA binding element, regulates its DNA binding activity through redox.
|
| |
J Biol Chem,
274,
29075-29080.
|
|
|
|
|
|
|
K.E.Hightower,
and
C.A.Fierke
(1999).
Zinc-catalyzed sulfur alkyation:insights from protein farnesyltransferase.
|
| |
Curr Opin Chem Biol,
3,
176-181.
|
|
|
|
|
|
|
K.Nadassy,
S.J.Wodak,
and
J.Janin
(1999).
Structural features of protein-nucleic acid recognition sites.
|
| |
Biochemistry,
38,
1999-2017.
|
|
|
|
|
|
|
P.J.van Tilborg,
F.A.Mulder,
M.M.de Backer,
M.Nair,
E.C.van Heerde,
G.Folkers,
P.T.van der Saag,
Y.Karimi-Nejad,
R.Boelens,
and
R.Kaptein
(1999).
Millisecond to microsecond time scale dynamics of the retinoid X and retinoic acid receptor DNA-binding domains and dimeric complex formation.
|
| |
Biochemistry,
38,
1951-1956.
|
|
|
|
|
|
|
R.Kumar,
I.V.Baskakov,
G.Srinivasan,
D.W.Bolen,
J.C.Lee,
and
E.B.Thompson
(1999).
Interdomain signaling in a two-domain fragment of the human glucocorticoid receptor.
|
| |
J Biol Chem,
274,
24737-24741.
|
|
|
|
|
|
|
R.V.Weatherman,
R.J.Fletterick,
and
T.S.Scanlan
(1999).
Nuclear-receptor ligands and ligand-binding domains.
|
| |
Annu Rev Biochem,
68,
559-581.
|
|
|
|
|
|
|
S.Chen,
C.H.Costa,
K.Nakamura,
R.C.Ribeiro,
and
D.G.Gardner
(1999).
Vitamin D-dependent suppression of human atrial natriuretic peptide gene promoter activity requires heterodimer assembly.
|
| |
J Biol Chem,
274,
11260-11266.
|
|
|
|
|
|
|
S.Chusacultanachai,
K.A.Glenn,
A.O.Rodriguez,
E.K.Read,
J.F.Gardner,
B.S.Katzenellenbogen,
and
D.J.Shapiro
(1999).
Analysis of estrogen response element binding by genetically selected steroid receptor DNA binding domain mutants exhibiting altered specificity and enhanced affinity.
|
| |
J Biol Chem,
274,
23591-23598.
|
|
|
|
|
|
|
S.Sen,
and
L.Nilsson
(1999).
Structure, interaction, dynamics and solvent effects on the DNA-EcoRI complex in aqueous solution from molecular dynamics simulation.
|
| |
Biophys J,
77,
1782-1800.
|
|
|
|
|
|
|
T.Uz,
Y.Dwivedi,
P.D.Savani,
F.Impagnatiello,
G.Pandey,
and
H.Manev
(1999).
Glucocorticoids stimulate inflammatory 5-lipoxygenase gene expression and protein translocation in the brain.
|
| |
J Neurochem,
73,
693-699.
|
|
|
|
|
|
|
X.Yao,
G.C.Pérez-Alvarado,
H.A.Louis,
P.Pomiès,
C.Hatt,
M.F.Summers,
and
M.C.Beckerle
(1999).
Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation.
|
| |
Biochemistry,
38,
5701-5713.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.W.Norman
(1998).
Receptors for 1alpha,25(OH)2D3: past, present, and future.
|
| |
J Bone Miner Res,
13,
1360-1369.
|
|
|
|
|
|
|
C.Massaad,
X.Coumoul,
M.Sabbah,
M.Garlatti,
G.Redeuilh,
and
R.Barouki
(1998).
Properties of overlapping EREs: synergistic activation of transcription and cooperative binding of ER.
|
| |
Biochemistry,
37,
6023-6032.
|
|
|
|
|
|
|
C.R.Robinson,
and
S.G.Sligar
(1998).
Changes in solvation during DNA binding and cleavage are critical to altered specificity of the EcoRI endonuclease.
|
| |
Proc Natl Acad Sci U S A,
95,
2186-2191.
|
|
|
|
|
|
|
C.Tzagarakis-Foster,
and
M.L.Privalsky
(1998).
Phosphorylation of thyroid hormone receptors by protein kinase A regulates DNA recognition by specific inhibition of receptor monomer binding.
|
| |
J Biol Chem,
273,
10926-10932.
|
|
|
|
|
|
|
D.Rabinovich,
H.Rozenberg,
and
Z.Shakked
(1998).
Molecular replacement: the revival of the molecular Fourier transform method.
|
| |
Acta Crystallogr D Biol Crystallogr,
54,
1336-1342.
|
|
|
|
|
|
|
E.Carosa,
A.Fanelli,
S.Ulisse,
R.Di Lauro,
J.E.Rall,
and
E.A.Jannini
(1998).
Ciona intestinalis nuclear receptor 1: a member of steroid/thyroid hormone receptor family.
|
| |
Proc Natl Acad Sci U S A,
95,
11152-11157.
|
|
|
|
|
|
|
F.Tronche,
C.Kellendonk,
H.M.Reichardt,
and
G.Schütz
(1998).
Genetic dissection of glucocorticoid receptor function in mice.
|
| |
Curr Opin Genet Dev,
8,
532-538.
|
|
|
|
|
|
|
G.B.Koudelka
(1998).
Recognition of DNA structure by 434 repressor.
|
| |
Nucleic Acids Res,
26,
669-675.
|
|
|
|
|
|
|
G.G.Préfontaine,
M.E.Lemieux,
W.Giffin,
C.Schild-Poulter,
L.Pope,
E.LaCasse,
P.Walker,
and
R.J.Haché
(1998).
Recruitment of octamer transcription factors to DNA by glucocorticoid receptor.
|
| |
Mol Cell Biol,
18,
3416-3430.
|
|
|
|
|
|
|
H.M.Reichardt,
and
G.Schütz
(1998).
Glucocorticoid signalling--multiple variations of a common theme.
|
| |
Mol Cell Endocrinol,
146,
1-6.
|
|
|
|
|
|
|
H.M.Reichardt,
K.H.Kaestner,
J.Tuckermann,
O.Kretz,
O.Wessely,
R.Bock,
P.Gass,
W.Schmid,
P.Herrlich,
P.Angel,
and
G.Schütz
(1998).
DNA binding of the glucocorticoid receptor is not essential for survival.
|
| |
Cell,
93,
531-541.
|
|
|
|
|
|
|
H.Terenzi,
P.M.Alzari,
and
M.M.Zakin
(1998).
Structural features involved in the formation of a complex between the monomeric or the dimeric form of the rev-erb beta DNA-binding domain and its DNA reactive sites.
|
| |
Biochemistry,
37,
11488-11495.
|
|
|
|
|
|
|
J.C.Corton,
E.Moreno,
and
S.A.Johnston
(1998).
Alterations in the GAL4 DNA-binding domain can affect transcriptional activation independent of DNA binding.
|
| |
J Biol Chem,
273,
13776-13780.
|
|
|
|
|
|
|
J.D.Klemm,
S.L.Schreiber,
and
G.R.Crabtree
(1998).
Dimerization as a regulatory mechanism in signal transduction.
|
| |
Annu Rev Immunol,
16,
569-592.
|
|
|
|
|
|
|
J.R.Wood,
G.L.Greene,
and
A.M.Nardulli
(1998).
Estrogen response elements function as allosteric modulators of estrogen receptor conformation.
|
| |
Mol Cell Biol,
18,
1927-1934.
|
|
|
|
|
|
|
K.D.Finley,
P.T.Edeen,
M.Foss,
E.Gross,
N.Ghbeish,
R.H.Palmer,
B.J.Taylor,
and
M.McKeown
(1998).
Dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior.
|
| |
Neuron,
21,
1363-1374.
|
|
|
|
|
|
|
L.Howe,
and
J.Ausió
(1998).
Nucleosome translational position, not histone acetylation, determines TFIIIA binding to nucleosomal Xenopus laevis 5S rRNA genes.
|
| |
Mol Cell Biol,
18,
1156-1162.
|
|
|
|
|
|
|
M.H.Hsu,
C.N.Palmer,
W.Song,
K.J.Griffin,
and
E.F.Johnson
(1998).
A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding.
|
| |
J Biol Chem,
273,
27988-27997.
|
|
|
|
|
|
|
M.Li,
X.Ye,
R.N.Woodward,
C.Zhu,
L.A.Nichols,
and
L.J.Holland
(1998).
Analysis of the DNA-binding site for Xenopus glucocorticoid receptor accessory factor. Critical nucleotides for binding specificity in vitro and for amplification of steroid-induced fibrinogen gene transcription.
|
| |
J Biol Chem,
273,
9790-9796.
|
|
|
|
|
|
|
M.Vögtli,
C.Elke,
M.O.Imhof,
and
M.Lezzi
(1998).
High level transactivation by the ecdysone receptor complex at the core recognition motif.
|
| |
Nucleic Acids Res,
26,
2407-2414.
|
|
|
|
|
|
|
Q.Zhao,
S.Khorasanizadeh,
Y.Miyoshi,
M.A.Lazar,
and
F.Rastinejad
(1998).
Structural elements of an orphan nuclear receptor-DNA complex.
|
| |
Mol Cell,
1,
849-861.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.A.Albright,
M.C.Mossing,
and
B.W.Matthews
(1998).
Crystal structure of an engineered Cro monomer bound nonspecifically to DNA: possible implications for nonspecific binding by the wild-type protein.
|
| |
Protein Sci,
7,
1485-1494.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.Konrat,
B.Kräutler,
R.Weiskirchen,
and
K.Bister
(1998).
Structure of cysteine- and glycine-rich protein CRP2. Backbone dynamics reveal motional freedom and independent spatial orientation of the lim domains.
|
| |
J Biol Chem,
273,
23233-23240.
|
|
|
|
|
|
|
S.Xiao,
S.R.Nalabolu,
J.C.Aster,
J.Ma,
L.Abruzzo,
E.S.Jaffe,
R.Stone,
S.M.Weissman,
T.J.Hudson,
and
J.A.Fletcher
(1998).
FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome.
|
| |
Nat Genet,
18,
84-87.
|
|
|
|
|
|
|
V.H.van der Velden
(1998).
Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma.
|
| |
Mediators Inflamm,
7,
229-237.
|
|
|
|
|
|
|
V.M.Christoffels,
T.Grange,
K.H.Kaestner,
T.J.Cole,
G.J.Darlington,
C.M.Croniger,
and
W.H.Lamers
(1998).
Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene.
|
| |
Mol Cell Biol,
18,
6305-6315.
|
|
|
|
|
|
|
Y.G.Kim,
J.Smith,
M.Durgesha,
and
S.Chandrasegaran
(1998).
Chimeric restriction enzyme: Gal4 fusion to FokI cleavage domain.
|
| |
Biol Chem,
379,
489-495.
|
|
|
|
|
|
|
A.K.Ostlund Farrants,
P.Blomquist,
H.Kwon,
and
O.Wrange
(1997).
Glucocorticoid receptor-glucocorticoid response element binding stimulates nucleosome disruption by the SWI/SNF complex.
|
| |
Mol Cell Biol,
17,
895-905.
|
|
|
|
|
|
|
B.A.Lieberman,
and
S.K.Nordeen
(1997).
DNA intersegment transfer, how steroid receptors search for a target site.
|
| |
J Biol Chem,
272,
1061-1068.
|
|
|
|
|
|
|
D.Kosztin,
T.C.Bishop,
and
K.Schulten
(1997).
Binding of the estrogen receptor to DNA. The role of waters.
|
| |
Biophys J,
73,
557-570.
|
|
|
|
|
|
|
D.S.Sem,
D.R.Casimiro,
S.A.Kliewer,
J.Provencal,
R.M.Evans,
and
P.E.Wright
(1997).
NMR spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2. The carboxyl-terminal extension to the zinc-finger region is unstructured in the free form of the protein.
|
| |
J Biol Chem,
272,
18038-18043.
|
|
|
|
|
|
|
E.Hatzivassiliou,
P.Cardot,
V.I.Zannis,
and
S.A.Mitsialis
(1997).
Ultraspiracle, a Drosophila retinoic X receptor alpha homologue, can mobilize the human thyroid hormone receptor to transactivate a human promoter.
|
| |
Biochemistry,
36,
9221-9231.
|
|
|
|
|
|
|
G.E.Carney,
A.A.Wade,
R.Sapra,
E.S.Goldstein,
and
M.Bender
(1997).
DHR3, an ecdysone-inducible early-late gene encoding a Drosophila nuclear receptor, is required for embryogenesis.
|
| |
Proc Natl Acad Sci U S A,
94,
12024-12029.
|
|
|
|
|
|
|
G.Jiang,
and
F.M.Sladek
(1997).
The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor alpha.
|
| |
J Biol Chem,
272,
1218-1225.
|
|
|
|
|
|
|
G.Jiang,
U.Lee,
and
F.M.Sladek
(1997).
Proposed mechanism for the stabilization of nuclear receptor DNA binding via protein dimerization.
|
| |
Mol Cell Biol,
17,
6546-6554.
|
|
|
|
|
|
|
G.Patikoglou,
and
S.K.Burley
(1997).
Eukaryotic transcription factor-DNA complexes.
|
| |
Annu Rev Biophys Biomol Struct,
26,
289-325.
|
|
|
|
|
|
|
H.Berglund,
M.Wolf-Watz,
T.Lundbäck,
S.van den Berg,
and
T.Härd
(1997).
Structure and dynamics of the glucocorticoid receptor DNA-binding domain: comparison of wild type and a mutant with altered specificity.
|
| |
Biochemistry,
36,
11188-11197.
|
|
|
|
|
|
|
H.T.Brüggenwirth,
A.L.Boehmer,
S.Ramnarain,
M.C.Verleun-Mooijman,
D.P.Satijn,
J.Trapman,
J.A.Grootegoed,
and
A.O.Brinkmann
(1997).
Molecular analysis of the androgen-receptor gene in a family with receptor-positive partial androgen insensitivity: an unusual type of intronic mutation.
|
| |
Am J Hum Genet,
61,
1067-1077.
|
|
|
|
|
|
|
J.A.Subirana,
and
T.Faria
(1997).
Influence of sequence on the conformation of the B-DNA helix.
|
| |
Biophys J,
73,
333-338.
|
|
|
|
|
|
|
J.D.Spahn,
D.Y.Leung,
and
S.J.Szefler
(1997).
New insights into the pathogenesis and management of steroid-resistant asthma.
|
| |
J Asthma,
34,
177-194.
|
|
|
|
|
|
|
J.G.Omichinski,
P.V.Pedone,
G.Felsenfeld,
A.M.Gronenborn,
and
G.M.Clore
(1997).
The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode.
|
| |
Nat Struct Biol,
4,
122-132.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.Liden,
F.Delaunay,
I.Rafter,
J.Gustafsson,
and
S.Okret
(1997).
A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation.
|
| |
J Biol Chem,
272,
21467-21472.
|
|
|
|
|
|
|
J.P.Kahlen,
and
C.Carlberg
(1997).
Allosteric interaction of the 1alpha,25-dihydroxyvitamin D3 receptor and the retinoid X receptor on DNA.
|
| |
Nucleic Acids Res,
25,
4307-4313.
|
|
|
|
|
|
|
J.R.Wilkinson,
and
H.C.Towle
(1997).
Identification and characterization of the AF-1 transactivation domain of thyroid hormone receptor beta1.
|
| |
J Biol Chem,
272,
23824-23832.
|
|
|
|
|
|
|
J.S.Albert,
M.W.Peczuh,
and
A.D.Hamilton
(1997).
Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an alpha-helical conformation.
|
| |
Bioorg Med Chem,
5,
1455-1467.
|
|
|
|
|
|
|
J.W.Schwabe
(1997).
The role of water in protein-DNA interactions.
|
| |
Curr Opin Struct Biol,
7,
126-134.
|
|
|
|
|
|
|
K.Grandien,
A.Berkenstam,
and
J.A.Gustafsson
(1997).
The estrogen receptor gene: promoter organization and expression.
|
| |
Int J Biochem Cell Biol,
29,
1343-1369.
|
|
|
|
|
|
|
K.L.Schmeichel,
and
M.C.Beckerle
(1997).
Molecular dissection of a LIM domain.
|
| |
Mol Biol Cell,
8,
219-230.
|
|
|
|
|
|
|
L.Jen-Jacobson
(1997).
Protein-DNA recognition complexes: conservation of structure and binding energy in the transition state.
|
| |
Biopolymers,
44,
153-180.
|
|
|
|
|
|
|
L.Li,
and
K.S.Matthews
(1997).
Differences in water release with DNA binding by ultrabithorax and deformed homeodomains.
|
| |
Biochemistry,
36,
7003-7011.
|
|
|
|
|
|
|
M.A.Kuntz,
and
D.J.Shapiro
(1997).
Dimerizing the estrogen receptor DNA binding domain enhances binding to estrogen response elements.
|
| |
J Biol Chem,
272,
27949-27956.
|
|
|
|
|
|
|
M.Beato,
and
K.Eisfeld
(1997).
Transcription factor access to chromatin.
|
| |
Nucleic Acids Res,
25,
3559-3563.
|
|
|
|
|
|
|
M.K.Bhat,
P.McPhie,
and
S.Cheng
(1997).
Critical role of glutamine 252 in the hormone-dependent transcriptional activity of the thyroid hormone beta1 nuclear receptor.
|
| |
Biochemistry,
36,
4233-4239.
|
|
|
|
|
|
|
M.S.Finnin,
M.P.Cicero,
C.Davies,
S.J.Porter,
S.W.White,
and
K.N.Kreuzer
(1997).
The activation domain of the MotA transcription factor from bacteriophage T4.
|
| |
EMBO J,
16,
1992-2003.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
P.Doesburg,
C.W.Kuil,
C.A.Berrevoets,
K.Steketee,
P.W.Faber,
E.Mulder,
A.O.Brinkmann,
and
J.Trapman
(1997).
Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor.
|
| |
Biochemistry,
36,
1052-1064.
|
|
|
|
|
|
|
P.Pace,
J.Taylor,
S.Suntharalingam,
R.C.Coombes,
and
S.Ali
(1997).
Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha.
|
| |
J Biol Chem,
272,
25832-25838.
|
|
|
|
|
|
|
S.Aliau,
D.El Garrouj,
A.Yasri,
B.S.Katzenellenbogen,
and
J.L.Borgna
(1997).
17 alpha (haloacetamidoalkyl) estradiols alkylate the human estrogen receptor at cysteine residues 417 and 530.
|
| |
Biochemistry,
36,
5861-5867.
|
|
|
|
|
|
|
S.Taraviras,
G.Schütz,
and
G.Kelsey
(1997).
Generation of inhibitory mutants of hepatocyte nuclear factor 4.
|
| |
Eur J Biochem,
244,
883-889.
|
|
|
|
|
|
|
T.C.Bishop,
D.Kosztin,
and
K.Schulten
(1997).
How hormone receptor-DNA binding affects nucleosomal DNA: the role of symmetry.
|
| |
Biophys J,
72,
2056-2067.
|
|
|
|
|
|
|
T.Meyer,
D.B.Starr,
and
J.Carlstedt-Duke
(1997).
The rat glucocorticoid receptor mutant K461A differentiates between two different mechanisms of transrepression.
|
| |
J Biol Chem,
272,
21090-21095.
|
|
|
|
|
|
|
Y.Tang,
C.Ramakrishnan,
J.Thomas,
and
D.B.DeFranco
(1997).
A role for HDJ-2/HSDJ in correcting subnuclear trafficking, transactivation, and transrepression defects of a glucocorticoid receptor zinc finger mutant.
|
| |
Mol Biol Cell,
8,
795-809.
|
|
|
|
|
|
|
Y.Z.Chen,
J.W.Powell,
and
E.W.Prohofsky
(1997).
Vibrational normal modes and dynamical stability of DNA triplex poly(dA). 2poly(dT): S-type structure is more stable and in better agreement with observations in solution.
|
| |
Biophys J,
72,
1327-1334.
|
|
|
|
|
|
|
A.G.Elefanty,
M.Antoniou,
N.Custodio,
M.Carmo-Fonseca,
and
F.G.Grosveld
(1996).
GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes.
|
| |
EMBO J,
15,
319-333.
|
|
|
|
|
|
|
A.Hammarström,
K.D.Berndt,
R.Sillard,
K.Adermann,
and
G.Otting
(1996).
Solution structure of a naturally-occurring zinc-peptide complex demonstrates that the N-terminal zinc-binding module of the Lasp-1 LIM domain is an independent folding unit.
|
| |
Biochemistry,
35,
12723-12732.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
B.D.Lemon,
and
L.P.Freedman
(1996).
Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo.
|
| |
Mol Cell Biol,
16,
1006-1016.
|
|
|
|
|
|
|
C.Brostjan,
J.Anrather,
V.Csizmadia,
D.Stroka,
M.Soares,
F.H.Bach,
and
H.Winkler
(1996).
Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis.
|
| |
J Biol Chem,
271,
19612-19616.
|
|
|
|
|
|
|
C.C.Nelson,
S.C.Hendy,
J.S.Faris,
and
P.J.Romaniuk
(1996).
Retinoid X receptor alters the determination of DNA binding specificity by the P-box amino acids of the thyroid hormone receptor.
|
| |
J Biol Chem,
271,
19464-19474.
|
|
|
|
|
|
|
C.Rachez,
P.Sautière,
P.Formstecher,
and
P.Lefebvre
(1996).
Identification of amino acids critical for the DNA binding and dimerization properties of the human retinoic acid receptor alpha. Importance of lysine 360, lysine 365, and valine 361.
|
| |
J Biol Chem,
271,
17996-18006.
|
|
|
|
|
|
|
C.Wenz,
A.Jeltsch,
and
A.Pingoud
(1996).
Probing the indirect readout of the restriction enzyme EcoRV. Mutational analysis of contacts to the DNA backbone.
|
| |
J Biol Chem,
271,
5565-5573.
|
|
|
|
|
|
|
D.A.Erlanson,
M.Chytil,
and
G.L.Verdine
(1996).
The leucine zipper domain controls the orientation of AP-1 in the NFAT.AP-1.DNA complex.
|
| |
Chem Biol,
3,
981-991.
|
|
|
|
|
|
|
D.G.Mottershead,
P.Polly,
R.J.Lyons,
R.L.Sutherland,
and
C.K.Watts
(1996).
High activity, soluble, bacterially expressed human vitamin D receptor and its ligand binding domain.
|
| |
J Cell Biochem,
61,
325-337.
|
|
|
|
|
|
|
I.Segard-Maurel,
K.Rajkowski,
N.Jibard,
G.Schweizer-Groyer,
E.E.Baulieu,
and
F.Cadepond
(1996).
Glucocorticosteroid receptor dimerization investigated by analysis of receptor binding to glucocorticosteroid responsive elements using a monomer-dimer equilibrium model.
|
| |
Biochemistry,
35,
1634-1642.
|
|
|
|
|
|
|
I.Tzameli,
and
V.I.Zannis
(1996).
Binding specificity and modulation of the ApoA-I promoter activity by homo- and heterodimers of nuclear receptors.
|
| |
J Biol Chem,
271,
8402-8415.
|
|
|
|
|
|
|
J.H.Pinter,
C.Deep,
and
O.K.Park-Sarge
(1996).
Progesterone receptors: expression and regulation in the mammalian ovary.
|
| |
Clin Obstet Gynecol,
39,
424-435.
|
|
|
|
|
|
|
J.P.Aumais,
H.S.Lee,
C.DeGannes,
J.Horsford,
and
J.H.White
(1996).
Function of directly repeated half-sites as response elements for steroid hormone receptors.
|
| |
J Biol Chem,
271,
12568-12577.
|
|
|
|
|
|
|
J.S.Hanas,
and
C.G.Gunn
(1996).
Inhibition of transcription factor IIIA-DNA interactions by xenobiotic metal ions.
|
| |
Nucleic Acids Res,
24,
924-930.
|
|
|
|
|
|
|
J.W.Schwabe
(1996).
Transcriptional control: how nuclear receptors get turned on.
|
| |
Curr Biol,
6,
372-374.
|
|
|
|
|
|
|
K.Baysal,
and
D.W.Losordo
(1996).
Oestrogen receptors and cardiovascular disease.
|
| |
Clin Exp Pharmacol Physiol,
23,
537-548.
|
|
|
|
|
|
|
M.Balbín,
and
C.López-Otín
(1996).
Hormonal regulation of the human pepsinogen C gene in breast cancer cells. Identification of a cis-acting element mediating its induction by androgens, glucocorticoids, and progesterone.
|
| |
J Biol Chem,
271,
15175-15181.
|
|
|
|
|
|
|
M.Beato,
M.Truss,
and
S.Chávez
(1996).
Control of transcription by steroid hormones.
|
| |
Ann N Y Acad Sci,
784,
93.
|
|
|
|
|
|
|
M.E.Saks,
and
J.R.Sampson
(1996).
Variant minihelix RNAs reveal sequence-specific recognition of the helical tRNA(Ser) acceptor stem by E.coli seryl-tRNA synthetase.
|
| |
EMBO J,
15,
2843-2849.
|
|
|
|
|
|
|
M.K.Agarwai
(1996).
The antiglucocorticoid action of mifepristone.
|
| |
Pharmacol Ther,
70,
183-213.
|
|
|
|
|
|
|
M.Suckow,
M.Lopata,
A.Seydel,
B.Kisters-Woike,
B.von Wilcken-Bergmann,
and
B.Müller-Hill
(1996).
Mutant bZip-DNA complexes with four quasi-identical protein-DNA interfaces.
|
| |
EMBO J,
15,
598-606.
|
|
|
|
|
|
|
M.Truss,
J.Bartsch,
C.Möws,
S.Chávez,
and
M.Beato
(1996).
Chromatin structure of the MMTV promoter and its changes during hormonal induction.
|
| |
Cell Mol Neurobiol,
16,
85.
|
|
|
|
|
|
|
M.Xu,
P.K.Chakraborti,
M.J.Garabedian,
K.R.Yamamoto,
and
S.S.Simons
(1996).
Modular structure of glucocorticoid receptor domains is not equivalent to functional independence. Stability and activity of the steroid binding domain are controlled by sequences in separate domains.
|
| |
J Biol Chem,
271,
21430-21438.
|
|
|
|
|
|
|
P.Blomquist,
Q.Li,
and
O.Wrange
(1996).
The affinity of nuclear factor 1 for its DNA site is drastically reduced by nucleosome organization irrespective of its rotational or translational position.
|
| |
J Biol Chem,
271,
153-159.
|
|
|
|
|
|
|
S.R.Patel,
R.J.Koenig,
and
C.H.Hsu
(1996).
Effect of Schiff base formation on the function of the calcitriol receptor.
|
| |
Kidney Int,
50,
1539-1545.
|
|
|
|
|
|
|
T.Härd,
and
T.Lundbäck
(1996).
Thermodynamics of sequence-specific protein-DNA interactions.
|
| |
Biophys Chem,
62,
121-139.
|
|
|
|
|
|
|
T.Lemberger,
B.Desvergne,
and
W.Wahli
(1996).
Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology.
|
| |
Annu Rev Cell Dev Biol,
12,
335-363.
|
|
|
|
|
|
|
T.Lundbäck,
and
T.Härd
(1996).
Sequence-specific DNA-binding dominated by dehydration.
|
| |
Proc Natl Acad Sci U S A,
93,
4754-4759.
|
|
|
|
|
|
|
X.Cao,
S.L.Teitelbaum,
H.J.Zhu,
L.Zhang,
X.Feng,
and
F.P.Ross
(1996).
Competition for a unique response element mediates retinoic acid inhibition of vitamin D3-stimulated transcription.
|
| |
J Biol Chem,
271,
20650-20654.
|
|
|
|
|
|
|
Y.Makino,
K.Okamoto,
N.Yoshikawa,
M.Aoshima,
K.Hirota,
J.Yodoi,
K.Umesono,
I.Makino,
and
H.Tanaka
(1996).
Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.
|
| |
J Clin Invest,
98,
2469-2477.
|
|
|
|
|
|
|
Y.Xue,
M.Murdjeva,
S.Okret,
D.McConkey,
D.Kiuossis,
and
M.Jondal
(1996).
Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice.
|
| |
Eur J Immunol,
26,
428-434.
|
|
|
|
|
|
|
Z.Dauter,
K.S.Wilson,
L.C.Sieker,
J.M.Moulis,
and
J.Meyer
(1996).
Zinc- and iron-rubredoxins from Clostridium pasteurianum at atomic resolution: a high-precision model of a ZnS4 coordination unit in a protein.
|
| |
Proc Natl Acad Sci U S A,
93,
8836-8840.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.H.Swirnoff,
and
J.Milbrandt
(1995).
DNA-binding specificity of NGFI-A and related zinc finger transcription factors.
|
| |
Mol Cell Biol,
15,
2275-2287.
|
|
|
|
|
|
|
A.K.Aggarwal
(1995).
A gripping end to NF-kappa B.
|
| |
Nat Struct Biol,
2,
184-186.
|
|
|
|
|
|
|
A.Klug
(1995).
Gene regulatory proteins and their interaction with DNA.
|
| |
Ann N Y Acad Sci,
758,
143-160.
|
|
|
|
|
|
|
A.M.Gronenborn,
and
G.M.Clore
(1995).
Structures of protein complexes by multidimensional heteronuclear magnetic resonance spectroscopy.
|
| |
Crit Rev Biochem Mol Biol,
30,
351-385.
|
|
|
|
|
|
|
B.E.Raumann,
K.L.Knight,
and
R.T.Sauer
(1995).
Dramatic changes in DNA-binding specificity caused by single residue substitutions in an Arc/Mnt hybrid repressor.
|
| |
Nat Struct Biol,
2,
1115-1122.
|
|
|
|
|
|
|
B.M.Forman,
and
R.M.Evans
(1995).
Nuclear hormone receptors activate direct, inverted, and everted repeats.
|
| |
Ann N Y Acad Sci,
761,
29-37.
|
|
|
|
|
|
|
C.C.Nelson,
S.C.Hendy,
and
P.J.Romaniuk
(1995).
Relationship between P-box amino acid sequence and DNA binding specificity of the thyroid hormone receptor. The effects of half-site sequence in everted repeats.
|
| |
J Biol Chem,
270,
16981-16987.
|
|
|
|
|
|
|
C.C.Nelson,
S.C.Hendy,
and
P.J.Romaniuk
(1995).
Relationship between P-box amino acid sequence and DNA binding specificity of the thyroid hormone receptor. The effects of sequences flanking half-sites in thyroid hormone response elements.
|
| |
J Biol Chem,
270,
16988-16994.
|
|
|
|
|
|
|
Cheng Sy
(1995).
New Insights into the Structure and Function of the Thyroid Hormone Receptor.
|
| |
J Biomed Sci,
2,
77-89.
|
|
|
|
|
|
|
D.J.Mangelsdorf,
and
R.M.Evans
(1995).
The RXR heterodimers and orphan receptors.
|
| |
Cell,
83,
841-850.
|
|
|
|
|
|
|
D.T.Gewirth,
and
P.B.Sigler
(1995).
The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex.
|
| |
Nat Struct Biol,
2,
386-394.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.V.Kuprash,
N.R.Rice,
and
S.A.Nedospasov
(1995).
Homodimer of p50 (NF kappa B1) does not introduce a substantial directed bend into DNA according to three different experimental assays.
|
| |
Nucleic Acids Res,
23,
427-433.
|
|
|
|
|
|
|
E.C.LaCasse,
and
Y.A.Lefebvre
(1995).
Nuclear localization signals overlap DNA- or RNA-binding domains in nucleic acid-binding proteins.
|
| |
Nucleic Acids Res,
23,
1647-1656.
|
|
|
|
|
|
|
E.Langley,
Z.X.Zhou,
and
E.M.Wilson
(1995).
Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer.
|
| |
J Biol Chem,
270,
29983-29990.
|
|
|
|
|
|
|
H.Chen,
and
M.L.Privalsky
(1995).
Cooperative formation of high-order oligomers by retinoid X receptors: an unexpected mode of DNA recognition.
|
| |
Proc Natl Acad Sci U S A,
92,
422-426.
|
|
|
|
|
|
|
H.H.Thole,
I.Maschler,
and
P.W.Jungblut
(1995).
Surface mapping of the ligand-filled C-terminal half of the porcine estradiol receptor by restricted proteolysis.
|
| |
Eur J Biochem,
231,
510-516.
|
|
|
|
|
|
|
H.P.Harding,
and
M.A.Lazar
(1995).
The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat.
|
| |
Mol Cell Biol,
15,
4791-4802.
|
|
|
|
|
|
|
H.Zaima,
N.Ueyama,
H.Adachi,
and
A.Nakamura
(1995).
1H-, 13C-, and 113Cd-NMR study of the Cd(II) complex of a blocked peptide, Z-Cys-Ala-Pro-His-OMe, in organic solvents.
|
| |
Biopolymers,
35,
319-329.
|
|
|
|
|
|
|
I.Alroy,
T.L.Towers,
and
L.P.Freedman
(1995).
Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor.
|
| |
Mol Cell Biol,
15,
5789-5799.
|
|
|
|
|
|
|
J.A.Lupisella,
J.E.Driscoll,
W.J.Metzler,
and
P.R.Reczek
(1995).
The ligand binding domain of the human retinoic acid receptor gamma is predominantly alpha-helical with a Trp residue in the ligand binding site.
|
| |
J Biol Chem,
270,
24884-24890.
|
|
|
|
|
|
|
J.E.Visvader,
M.Crossley,
J.Hill,
S.H.Orkin,
and
J.M.Adams
(1995).
The C-terminal zinc finger of GATA-1 or GATA-2 is sufficient to induce megakaryocytic differentiation of an early myeloid cell line.
|
| |
Mol Cell Biol,
15,
634-641.
|
|
|
|
|
|
|
J.Nishikawa,
M.Kitaura,
M.Imagawa,
and
T.Nishihara
(1995).
Vitamin D receptor contains multiple dimerization interfaces that are functionally different.
|
| |
Nucleic Acids Res,
23,
606-611.
|
|
|
|
|
|
|
J.P.Renaud,
N.Rochel,
M.Ruff,
V.Vivat,
P.Chambon,
H.Gronemeyer,
and
D.Moras
(1995).
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.
|
| |
Nature,
378,
681-689.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Roux,
R.Pictet,
and
T.Grange
(1995).
Hepatocyte nuclear factor 3 determines the amplitude of the glucocorticoid response of the rat tyrosine aminotransferase gene.
|
| |
DNA Cell Biol,
14,
385-396.
|
|
|
|
|
|
|
J.S.Qi,
V.Desai-Yajnik,
M.E.Greene,
B.M.Raaka,
and
H.H.Samuels
(1995).
The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation.
|
| |
Mol Cell Biol,
15,
1817-1825.
|
|
|
|
|
|
|
J.W.Schwabe,
L.Chapman,
and
D.Rhodes
(1995).
The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation.
|
| |
Structure,
3,
201-213.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.Neuman,
A.Soosaar,
H.O.Nornes,
and
T.Neuman
(1995).
Orphan receptor COUP-TF I antagonizes retinoic acid-induced neuronal differentiation.
|
| |
J Neurosci Res,
41,
39-48.
|
|
|
|
|
|
|
L.D.McBroom,
G.Flock,
and
V.Giguère
(1995).
The nonconserved hinge region and distinct amino-terminal domains of the ROR alpha orphan nuclear receptor isoforms are required for proper DNA bending and ROR alpha-DNA interactions.
|
| |
Mol Cell Biol,
15,
796-808.
|
|
|
|
|
|
|
L.Shimoni,
and
J.P.Glusker
(1995).
Hydrogen bonding motifs of protein side chains: descriptions of binding of arginine and amide groups.
|
| |
Protein Sci,
4,
65-74.
|
|
|
|
|
|
|
M.A.Eriksson,
T.Härd,
and
L.Nilsson
(1995).
Molecular dynamics simulations of the glucocorticoid receptor DNA-binding domain in complex with DNA and free in solution.
|
| |
Biophys J,
68,
402-426.
|
|
|
|
|
|
|
M.A.Young,
G.Ravishanker,
D.L.Beveridge,
and
H.M.Berman
(1995).
Analysis of local helix bending in crystal structures of DNA oligonucleotides and DNA-protein complexes.
|
| |
Biophys J,
68,
2454-2468.
|
|
|
|
|
|
|
M.Crossley,
M.Merika,
and
S.H.Orkin
(1995).
Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains.
|
| |
Mol Cell Biol,
15,
2448-2456.
|
|
|
|
|
|
|
M.L.Espinás,
J.Roux,
R.Pictet,
and
T.Grange
(1995).
Glucocorticoids and protein kinase A coordinately modulate transcription factor recruitment at a glucocorticoid-responsive unit.
|
| |
Mol Cell Biol,
15,
5346-5354.
|
|
|
|
|
|
|
M.Suzuki,
and
M.Gerstein
(1995).
Binding geometry of alpha-helices that recognize DNA.
|
| |
Proteins,
23,
525-535.
|
|
|
|
|
|
|
M.Suzuki,
and
N.Yagi
(1995).
Stereochemical basis of DNA bending by transcription factors.
|
| |
Nucleic Acids Res,
23,
2083-2091.
|
|
|
|
|
|
|
N.D.Arbuckle,
and
B.Luisi
(1995).
A recipe for specificity.
|
| |
Nat Struct Biol,
2,
341-346.
|
|
|
|
|
|
|
Q.Li,
and
O.Wrange
(1995).
Accessibility of a glucocorticoid response element in a nucleosome depends on its rotational positioning.
|
| |
Mol Cell Biol,
15,
4375-4384.
|
|
|
|
|
|
|
R.C.Ribeiro,
J.W.Apriletti,
B.L.West,
R.L.Wagner,
R.J.Fletterick,
F.Schaufele,
and
J.D.Baxter
(1995).
The molecular biology of thyroid hormone action.
|
| |
Ann N Y Acad Sci,
758,
366-389.
|
|
|
|
|
|
|
R.J.Austin,
and
M.D.Biggin
(1995).
A domain of the even-skipped protein represses transcription by preventing TFIID binding to a promoter: repression by cooperative blocking.
|
| |
Mol Cell Biol,
15,
4683-4693.
|
|
|
|
|
|
|
R.L.Wagner,
J.W.Apriletti,
M.E.McGrath,
B.L.West,
J.D.Baxter,
and
R.J.Fletterick
(1995).
A structural role for hormone in the thyroid hormone receptor.
|
| |
Nature,
378,
690-697.
|
|
|
|
|
|
|
R.S.Devon,
D.J.Porteous,
and
A.J.Brookes
(1995).
Splinkerettes--improved vectorettes for greater efficiency in PCR walking.
|
| |
Nucleic Acids Res,
23,
1644-1645.
|
|
|
|
|
|
|
S.E.Rundlett,
and
R.L.Miesfeld
(1995).
Quantitative differences in androgen and glucocorticoid receptor DNA binding properties contribute to receptor-selective transcriptional regulation.
|
| |
Mol Cell Endocrinol,
109,
1.
|
|
|
|
|
|
|
S.Kato,
H.Sasaki,
M.Suzawa,
S.Masushige,
L.Tora,
P.Chambon,
and
H.Gronemeyer
(1995).
Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors.
|
| |
Mol Cell Biol,
15,
5858-5867.
|
|
|
|
|
|
|
V.Giguère,
L.D.McBroom,
and
G.Flock
(1995).
Determinants of target gene specificity for ROR alpha 1: monomeric DNA binding by an orphan nuclear receptor.
|
| |
Mol Cell Biol,
15,
2517-2526.
|
|
|
|
|
|
|
V.Saha,
T.Chaplin,
A.Gregorini,
P.Ayton,
and
B.D.Young
(1995).
The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins.
|
| |
Proc Natl Acad Sci U S A,
92,
9737-9741.
|
|
|
|
|
|
|
W.Liu,
J.Wang,
N.K.Sauter,
and
D.Pearce
(1995).
Steroid receptor heterodimerization demonstrated in vitro and in vivo.
|
| |
Proc Natl Acad Sci U S A,
92,
12480-12484.
|
|
|
|
|
|
|
Y.Ogata,
M.Yamauchi,
R.H.Kim,
J.J.Li,
L.P.Freedman,
and
J.Sodek
(1995).
Glucocorticoid regulation of bone sialoprotein (BSP) gene expression. Identification of a glucocorticoid response element in the bone sialoprotein gene promoter.
|
| |
Eur J Biochem,
230,
183-192.
|
|
|
|
|
|
|
A.O.Brinkmann
(1994).
Steroid hormone receptors: activators of gene transcription.
|
| |
J Pediatr Endocrinol,
7,
275-282.
|
|
|
|
|
|
|
A.P.Wolffe
(1994).
Nucleosome positioning and modification: chromatin structures that potentiate transcription.
|
| |
Trends Biochem Sci,
19,
240-244.
|
|
|
|
|
|
|
A.R.Rut,
M.Hewison,
K.Kristjansson,
B.Luisi,
M.R.Hughes,
and
J.L.O'Riordan
(1994).
Two mutations causing vitamin D resistant rickets: modelling on the basis of steroid hormone receptor DNA-binding domain crystal structures.
|
| |
Clin Endocrinol (Oxf),
41,
581-590.
|
|
|
|
|
|
|
A.V.Hine,
and
C.C.Richardson
(1994).
A functional chimeric DNA primase: the Cys4 zinc-binding domain of bacteriophage T3 primase fused to the helicase of bacteriophage T7.
|
| |
Proc Natl Acad Sci U S A,
91,
12327-12331.
|
|
|
|
|
|
|
B.Cheskis,
and
L.P.Freedman
(1994).
Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers.
|
| |
Mol Cell Biol,
14,
3329-3338.
|
|
|
|
|
|
|
C.Antoniewski,
M.Laval,
A.Dahan,
and
J.A.Lepesant
(1994).
The ecdysone response enhancer of the Fbp1 gene of Drosophila melanogaster is a direct target for the EcR/USP nuclear receptor.
|
| |
Mol Cell Biol,
14,
4465-4474.
|
|
|
|
|
|
|
C.K.Ohno,
H.Ueda,
and
M.Petkovich
(1994).
The Drosophila nuclear receptors FTZ-F1 alpha and FTZ-F1 beta compete as monomers for binding to a site in the fushi tarazu gene.
|
| |
Mol Cell Biol,
14,
3166-3175.
|
|
|
|
|
|
|
C.P.White,
N.A.Morrison,
E.M.Gardiner,
and
J.A.Eisman
(1994).
Vitamin D receptor alleles and bone physiology.
|
| |
J Cell Biochem,
56,
307-314.
|
|
|
|
|
|
|
C.Ris-Stalpers,
M.C.Verleun-Mooijman,
T.J.de Blaeij,
H.J.Degenhart,
J.Trapman,
and
A.O.Brinkmann
(1994).
Differential splicing of human androgen receptor pre-mRNA in X-linked Reifenstein syndrome, because of a deletion involving a putative branch site.
|
| |
Am J Hum Genet,
54,
609-617.
|
|
|
|
|
|
|
C.Zechel,
X.Q.Shen,
J.Y.Chen,
Z.P.Chen,
P.Chambon,
and
H.Gronemeyer
(1994).
The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.
|
| |
EMBO J,
13,
1425-1433.
|
|
|
|
|
|
|
C.Zechel,
X.Q.Shen,
P.Chambon,
and
H.Gronemeyer
(1994).
Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.
|
| |
EMBO J,
13,
1414-1424.
|
|
|
|
|
|
|
D.J.Rozansky,
H.Wu,
K.Tang,
R.J.Parmer,
and
D.T.O'Connor
(1994).
Glucocorticoid activation of chromogranin A gene expression. Identification and characterization of a novel glucocorticoid response element.
|
| |
J Clin Invest,
94,
2357-2368.
|
|
|
|
|
|
|
E.P.Slater,
H.Hesse,
and
M.Beato
(1994).
Regulation of transcription by steroid hormones.
|
| |
Ann N Y Acad Sci,
733,
103-112.
|
|
|
|
|
|
|
F.Bouillaud,
I.Arechaga,
P.X.Petit,
S.Raimbault,
C.Levi-Meyrueis,
L.Casteilla,
M.Laurent,
E.Rial,
and
D.Ricquier
(1994).
A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein.
|
| |
EMBO J,
13,
1990-1997.
|
|
|
|
|
|
|
G.C.Pérez-Alvarado,
C.Miles,
J.W.Michelsen,
H.A.Louis,
D.R.Winge,
M.C.Beckerle,
and
M.F.Summers
(1994).
Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP.
|
| |
Nat Struct Biol,
1,
388-398.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
G.M.Clore,
and
A.M.Gronenborn
(1994).
Young Investigator Award Lecture. Structures of larger proteins, protein-ligand and protein-DNA complexes by multidimensional heteronuclear NMR.
|
| |
Protein Sci,
3,
372-390.
|
|
|
|
|
|
|
G.Mukhopadhyay,
S.Sozhamannan,
and
D.K.Chattoraj
(1994).
Relaxation of replication control in chaperone-independent initiator mutants of plasmid P1.
|
| |
EMBO J,
13,
2089-2096.
|
|
|
|
|
|
|
J.Casanova,
E.Helmer,
S.Selmi-Ruby,
J.S.Qi,
M.Au-Fliegner,
V.Desai-Yajnik,
N.Koudinova,
F.Yarm,
B.M.Raaka,
and
H.H.Samuels
(1994).
Functional evidence for ligand-dependent dissociation of thyroid hormone and retinoic acid receptors from an inhibitory cellular factor.
|
| |
Mol Cell Biol,
14,
5756-5765.
|
|
|
|
|
|
|
J.Pfau,
D.N.Arvidson,
and
P.Youderian
(1994).
Mutants of Escherichia coli Trp repressor with changes of conserved, helix-turn-helix residue threonine 81 have altered DNA-binding specificities.
|
| |
Mol Microbiol,
13,
1001-1012.
|
|
|
|
|
|
|
J.Yang,
and
D.B.DeFranco
(1994).
Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen.
|
| |
Mol Cell Biol,
14,
5088-5098.
|
|
|
|
|
|
|
J.Zilliacus,
J.Carlstedt-Duke,
J.A.Gustafsson,
and
A.P.Wright
(1994).
Evolution of distinct DNA-binding specificities within the nuclear receptor family of transcription factors.
|
| |
Proc Natl Acad Sci U S A,
91,
4175-4179.
|
|
|
|
|
|
|
L.Nekludova,
and
C.O.Pabo
(1994).
Distinctive DNA conformation with enlarged major groove is found in Zn-finger-DNA and other protein-DNA complexes.
|
| |
Proc Natl Acad Sci U S A,
91,
6948-6952.
|
|
|
|
|
|
|
L.V.Mendelman,
B.B.Beauchamp,
and
C.C.Richardson
(1994).
Requirement for a zinc motif for template recognition by the bacteriophage T7 primase.
|
| |
EMBO J,
13,
3909-3916.
|
|
|
|
|
|
|
M.Garlatti,
M.Daheshia,
E.Slater,
J.Bouguet,
J.Hanoune,
M.Beato,
and
R.Barouki
(1994).
A functional glucocorticoid-responsive unit composed of two overlapping inactive receptor-binding sites: evidence for formation of a receptor tetramer.
|
| |
Mol Cell Biol,
14,
8007-8017.
|
|
|
|
|
|
|
M.H.Werner,
G.M.Clore,
A.M.Gronenborn,
and
H.A.Nash
(1994).
Symmetry and asymmetry in the function of Escherichia coli integration host factor: implications for target identification by DNA-binding proteins.
|
| |
Curr Biol,
4,
477-487.
|
|
|
|
|
|
|
M.Joëls,
and
E.R.de Kloet
(1994).
Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems.
|
| |
Prog Neurobiol,
43,
1.
|
|
|
|
|
|
|
M.L.Espinás,
J.Roux,
J.Ghysdael,
R.Pictet,
and
T.Grange
(1994).
Participation of Ets transcription factors in the glucocorticoid response of the rat tyrosine aminotransferase gene.
|
| |
Mol Cell Biol,
14,
4116-4125.
|
|
|
|
|
|
|
M.S.Finnin,
D.W.Hoffman,
and
S.W.White
(1994).
The DNA-binding domain of the MotA transcription factor from bacteriophage T4 shows structural similarity to the TATA-binding protein.
|
| |
Proc Natl Acad Sci U S A,
91,
10972-10976.
|
|
|
|
|
|
|
M.S.Lee,
D.S.Sem,
S.A.Kliewer,
J.Provencal,
R.M.Evans,
and
P.E.Wright
(1994).
NMR assignments and secondary structure of the retinoid X receptor alpha DNA-binding domain. Evidence for the novel C-terminal helix.
|
| |
Eur J Biochem,
224,
639-650.
|
|
|
|
|
|
|
M.Suzuki,
and
N.Yagi
(1994).
DNA recognition code of transcription factors in the helix-turn-helix, probe helix, hormone receptor, and zinc finger families.
|
| |
Proc Natl Acad Sci U S A,
91,
12357-12361.
|
|
|
|
|
|
|
M.Suzuki
(1994).
A framework for the DNA-protein recognition code of the probe helix in transcription factors: the chemical and stereochemical rules.
|
| |
Structure,
2,
317-326.
|
|
|
|
|
|
|
N.Fabris
(1994).
Neuroendocrine-immune aging: an integrative view on the role of zinc.
|
| |
Ann N Y Acad Sci,
719,
353-368.
|
|
|
|
|
|
|
P.F.Predki,
and
B.Sarkar
(1994).
Metal replacement in "zinc finger" and its effect on DNA binding.
|
| |
Environ Health Perspect,
102,
195-198.
|
|
|
|
|
|
|
P.Sengupta,
H.A.Colbert,
and
C.I.Bargmann
(1994).
The C. elegans gene odr-7 encodes an olfactory-specific member of the nuclear receptor superfamily.
|
| |
Cell,
79,
971-980.
|
|
|
|
|
|
|
R.M.de Waal
(1994).
The anti-inflammatory activity of glucocorticoids.
|
| |
Mol Biol Rep,
19,
81-88.
|
|
|
|
|
|
|
S.Heck,
M.Kullmann,
A.Gast,
H.Ponta,
H.J.Rahmsdorf,
P.Herrlich,
and
A.C.Cato
(1994).
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.
|
| |
EMBO J,
13,
4087-4095.
|
|
|
|
|
|
|
S.K.Burley
(1994).
Plus ça change, plus c'est la même chose.
|
| |
Nat Struct Biol,
1,
207-208.
|
|
|
|
|
|
|
T.E.O'Toole,
Y.Katagiri,
R.J.Faull,
K.Peter,
R.Tamura,
V.Quaranta,
J.C.Loftus,
S.J.Shattil,
and
M.H.Ginsberg
(1994).
Integrin cytoplasmic domains mediate inside-out signal transduction.
|
| |
J Cell Biol,
124,
1047-1059.
|
|
|
|
|
|
|
U.Moens,
N.Subramaniam,
B.Johansen,
T.Johansen,
and
T.Traavik
(1994).
A steroid hormone response unit in the late leader of the noncoding control region of the human polyomavirus BK confers enhanced host cell permissivity.
|
| |
J Virol,
68,
2398-2408.
|
|
|
|
|
|
|
Z.Luo,
J.Rouvinen,
and
P.H.Mäenpää
(1994).
A peptide C-terminal to the second Zn finger of human vitamin D receptor is able to specify nuclear localization.
|
| |
Eur J Biochem,
223,
381-387.
|
|
|
|
|
|
|
A.D.Sharrocks,
H.Gille,
and
P.E.Shaw
(1993).
Identification of amino acids essential for DNA binding and dimerization in p67SRF: implications for a novel DNA-binding motif.
|
| |
Mol Cell Biol,
13,
123-132.
|
|
|
|
|
|
|
B.Cuenoud,
and
A.Schepartz
(1993).
Design of a metallo-bZIP protein that discriminates between CRE and AP1 target sites: selection against AP1.
|
| |
Proc Natl Acad Sci U S A,
90,
1154-1159.
|
|
|
|
|
|
|
F.Kaspar,
H.Klocker,
A.Denninger,
and
A.C.Cato
(1993).
A mutant androgen receptor from patients with Reifenstein syndrome: identification of the function of a conserved alanine residue in the D box of steroid receptors.
|
| |
Mol Cell Biol,
13,
7850-7858.
|
|
|
|
|
|
|
G.Fang,
and
T.R.Cech
(1993).
Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits.
|
| |
Proc Natl Acad Sci U S A,
90,
6056-6060.
|
|
|
|
|
|
|
G.J.Liaw,
E.Steingrimsson,
F.Pignoni,
A.J.Courey,
and
J.A.Lengyel
(1993).
Characterization of downstream elements in a Raf-1 pathway.
|
| |
Proc Natl Acad Sci U S A,
90,
858-862.
|
|
|
|
|
|
|
H.Chen,
Z.Smit-McBride,
S.Lewis,
M.Sharif,
and
M.L.Privalsky
(1993).
Nuclear hormone receptors involved in neoplasia: erb A exhibits a novel DNA sequence specificity determined by amino acids outside of the zinc-finger domain.
|
| |
Mol Cell Biol,
13,
2366-2376.
|
|
|
|
|
|
|
H.G.Stunnenberg
(1993).
Mechanisms of transactivation by retinoic acid receptors.
|
| |
Bioessays,
15,
309-315.
|
|
|
|
|
|
|
H.P.Harding,
and
M.A.Lazar
(1993).
The orphan receptor Rev-ErbA alpha activates transcription via a novel response element.
|
| |
Mol Cell Biol,
13,
3113-3121.
|
|
|
|
|
|
|
H.W.Chen,
and
M.L.Privalsky
(1993).
The erbA oncogene represses the actions of both retinoid X and retinoid A receptors but does so by distinct mechanisms.
|
| |
Mol Cell Biol,
13,
5970-5980.
|
|
|
|
|
|
|
J.G.Omichinski,
C.Trainor,
T.Evans,
A.M.Gronenborn,
G.M.Clore,
and
G.Felsenfeld
(1993).
A small single-"finger" peptide from the erythroid transcription factor GATA-1 binds specifically to DNA as a zinc or iron complex.
|
| |
Proc Natl Acad Sci U S A,
90,
1676-1680.
|
|
|
|
|
|
|
J.M.Lobaccaro,
S.Lumbroso,
C.Belon,
F.Galtier-Dereure,
J.Bringer,
T.Lesimple,
J.F.Heron,
H.Pujol,
and
C.Sultan
(1993).
Male breast cancer and the androgen receptor gene.
|
| |
Nat Genet,
5,
109-110.
|
|
|
|
|
|
|
J.Schmitt,
and
H.G.Stunnenberg
(1993).
The glucocorticoid receptor hormone binding domain mediates transcriptional activation in vitro in the absence of ligand.
|
| |
Nucleic Acids Res,
21,
2673-2681.
|
|
|
|
|
|
|
J.Trapman,
and
A.O.Brinkmann
(1993).
Mutations in the androgen receptor.
|
| |
Ann N Y Acad Sci,
684,
85-93.
|
|
|
|
|
|
|
J.W.Michelsen,
K.L.Schmeichel,
M.C.Beckerle,
and
D.R.Winge
(1993).
The LIM motif defines a specific zinc-binding protein domain.
|
| |
Proc Natl Acad Sci U S A,
90,
4404-4408.
|
|
|
|
|
|
|
J.W.Schwabe,
L.Chapman,
J.T.Finch,
and
D.Rhodes
(1993).
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements.
|
| |
Cell,
75,
567-578.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.W.Schwabe,
L.Chapman,
J.T.Finch,
D.Rhodes,
and
D.Neuhaus
(1993).
DNA recognition by the oestrogen receptor: from solution to the crystal.
|
| |
Structure,
1,
187-204.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.Zilliacus,
A.P.Wright,
U.Norinder,
J.A.Gustafsson,
and
J.Carlstedt-Duke
(1993).
DNA-binding specificity of mutant glucocorticoid receptor DNA-binding domains.
|
| |
Ann N Y Acad Sci,
684,
253-255.
|
|
|
|
|
|
|
K.Cohen-Solal,
A.Bailly,
C.Rauch,
M.Quesne,
and
E.Milgrom
(1993).
Specific binding of progesterone receptor to progesterone-responsive elements does not require prior dimerization.
|
| |
Eur J Biochem,
214,
189-195.
|
|
|
|
|
|
|
K.Frech,
G.Herrmann,
and
T.Werner
(1993).
Computer-assisted prediction, classification, and delimitation of protein binding sites in nucleic acids.
|
| |
Nucleic Acids Res,
21,
1655-1664.
|
|
|
|
|
|
|
K.Kristjansson,
A.R.Rut,
M.Hewison,
J.L.O'Riordan,
and
M.R.Hughes
(1993).
Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3.
|
| |
J Clin Invest,
92,
12-16.
|
|
|
|
|
|
|
L.F.Harris,
M.R.Sullivan,
and
D.F.Hickok
(1993).
Conservation of genetic information: a code for site-specific DNA recognition.
|
| |
Proc Natl Acad Sci U S A,
90,
5534-5538.
|
|
|
|
|
|
|
L.P.Freedman,
and
B.F.Luisi
(1993).
On the mechanism of DNA binding by nuclear hormone receptors: a structural and functional perspective.
|
| |
J Cell Biochem,
51,
140-150.
|
|
|
|
|
|
|
M.Au-Fliegner,
E.Helmer,
J.Casanova,
B.M.Raaka,
and
H.H.Samuels
(1993).
The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation.
|
| |
Mol Cell Biol,
13,
5725-5737.
|
|
|
|
|
|
|
M.B.Toledano,
D.Ghosh,
F.Trinh,
and
W.J.Leonard
(1993).
N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65.
|
| |
Mol Cell Biol,
13,
852-860.
|
|
|
|
|
|
|
M.G.Parker
(1993).
Steroid and related receptors.
|
| |
Curr Opin Cell Biol,
5,
499-504.
|
|
|
|
|
|
|
M.Hewison,
A.R.Rut,
K.Kristjansson,
R.E.Walker,
M.J.Dillon,
M.R.Hughes,
and
J.L.O'Riordan
(1993).
Tissue resistance to 1,25-dihydroxyvitamin D without a mutation of the vitamin D receptor gene.
|
| |
Clin Endocrinol (Oxf),
39,
663-670.
|
|
|
|
|
|
|
M.Karin,
H.F.Yang-Yen,
J.C.Chambard,
T.Deng,
and
F.Saatcioglu
(1993).
Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones.
|
| |
Eur J Clin Pharmacol,
45,
S9.
|
|
|
|
|
|
|
M.L.Whitelaw,
M.Göttlicher,
J.A.Gustafsson,
and
L.Poellinger
(1993).
Definition of a novel ligand binding domain of a nuclear bHLH receptor: co-localization of ligand and hsp90 binding activities within the regulable inactivation domain of the dioxin receptor.
|
| |
EMBO J,
12,
4169-4179.
|
|
|
|
|
|
|
M.Molinete,
W.Vermeulen,
A.Bürkle,
J.Ménissier-de Murcia,
J.H.Küpper,
J.H.Hoeijmakers,
and
G.de Murcia
(1993).
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.
|
| |
EMBO J,
12,
2109-2117.
|
|
|
|
|
|
|
M.Suzuki
(1993).
Common features in DNA recognition helices of eukaryotic transcription factors.
|
| |
EMBO J,
12,
3221-3226.
|
|
|
|
|
|
|
M.Whitelaw,
I.Pongratz,
A.Wilhelmsson,
J.A.Gustafsson,
and
L.Poellinger
(1993).
Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor.
|
| |
Mol Cell Biol,
13,
2504-2514.
|
|
|
|
|
|
|
O.A.Jänne,
J.J.Palvimo,
P.Kallio,
and
M.Mehto
(1993).
Androgen receptor and mechanism of androgen action.
|
| |
Ann Med,
25,
83-89.
|
|
|
|
|
|
|
P.A.Montgomery,
G.K.Scott,
M.C.Luce,
M.Kaufmann,
and
C.C.Benz
(1993).
Human breast tumors containing non-DNA-binding immunoreactive (67 kDa) estrogen receptor.
|
| |
Breast Cancer Res Treat,
26,
181-189.
|
|
|
|
|
|
|
P.J.Barnes,
and
I.Adcock
(1993).
Anti-inflammatory actions of steroids: molecular mechanisms.
|
| |
Trends Pharmacol Sci,
14,
436-441.
|
|
|
|
|
|
|
P.S.Freemont
(1993).
The RING finger. A novel protein sequence motif related to the zinc finger.
|
| |
Ann N Y Acad Sci,
684,
174-192.
|
|
|
|
|
|
|
P.Z.Wang,
S.J.Projan,
V.Henriquez,
and
R.P.Novick
(1993).
Origin recognition specificity in pT181 plasmids is determined by a functionally asymmetric palindromic DNA element.
|
| |
EMBO J,
12,
45-52.
|
|
|
|
|
|
|
R.A.Goldstein,
J.A.Katzenellenbogen,
Z.A.Luthey-Schulten,
D.A.Seielstad,
and
P.G.Wolynes
(1993).
Three-dimensional model for the hormone binding domains of steroid receptors.
|
| |
Proc Natl Acad Sci U S A,
90,
9949-9953.
|
|
|
|
|
|
|
R.Lovering,
I.M.Hanson,
K.L.Borden,
S.Martin,
N.J.O'Reilly,
G.I.Evan,
D.Rahman,
D.J.Pappin,
J.Trowsdale,
and
P.S.Freemont
(1993).
Identification and preliminary characterization of a protein motif related to the zinc finger.
|
| |
Proc Natl Acad Sci U S A,
90,
2112-2116.
|
|
|
|
|
|
|
R.M.Knegtel,
R.Boelens,
M.L.Ganadu,
A.V.George,
M.Katahira,
A.M.Bonvin,
D.Eib,
P.T.van der Saag,
and
R.Kaptein
(1993).
NMR studies of the human retinoic acid receptor-beta DNA-binding domain. Metal coordination and three-dimensional structure.
|
| |
Ann N Y Acad Sci,
684,
49-62.
|
|
|
|
|
|
|
S.Cuthill,
G.J.Sibbet,
and
M.S.Campo
(1993).
Characterization of a nuclear factor, papilloma enhancer binding factor-1, that binds the long control region of human papillomavirus type 16 and contributes to enhancer activity.
|
| |
Mol Carcinog,
8,
96.
|
|
|
|
|
|
|
S.Mader,
and
J.H.White
(1993).
A steroid-inducible promoter for the controlled overexpression of cloned genes in eukaryotic cells.
|
| |
Proc Natl Acad Sci U S A,
90,
5603-5607.
|
|
|
|
|
|
|
S.Mader,
J.Y.Chen,
Z.Chen,
J.White,
P.Chambon,
and
H.Gronemeyer
(1993).
The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.
|
| |
EMBO J,
12,
5029-5041.
|
|
|
|
|
|
|
S.Mader,
P.Chambon,
and
J.H.White
(1993).
Defining a minimal estrogen receptor DNA binding domain.
|
| |
Nucleic Acids Res,
21,
1125-1132.
|
|
|
|
|
|
|
S.R.Grant,
S.Hardenack,
S.Trentmann,
and
H.Saedler
(1993).
Functional cis-element sequence requirements for suppression of gene expression by the TNPA protein of the Zea mays transposon En/Spm.
|
| |
Mol Gen Genet,
241,
153-160.
|
|
|
|
|
|
|
T.E.Wilson,
K.A.Padgett,
M.Johnston,
and
J.Milbrandt
(1993).
A genetic method for defining DNA-binding domains: application to the nuclear receptor NGFI-B.
|
| |
Proc Natl Acad Sci U S A,
90,
9186-9190.
|
|
|
|
|
|
|
T.E.Wilson,
T.J.Fahrner,
and
J.Milbrandt
(1993).
The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.
|
| |
Mol Cell Biol,
13,
5794-5804.
|
|
|
|
|
|
|
T.L.Towers,
B.F.Luisi,
A.Asianov,
and
L.P.Freedman
(1993).
DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element.
|
| |
Proc Natl Acad Sci U S A,
90,
6310-6314.
|
|
|
|
|
|
|
X.P.Lu,
N.L.Eberhardt,
and
M.Pfahl
(1993).
DNA bending by retinoid X receptor-containing retinoid and thyroid hormone receptor complexes.
|
| |
Mol Cell Biol,
13,
6509-6519.
|
|
|
|
|
|
|
A.J.Cooney,
S.Y.Tsai,
B.W.O'Malley,
and
M.J.Tsai
(1992).
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.
|
| |
Mol Cell Biol,
12,
4153-4163.
|
|
|
|
|
|
|
A.M.Nardulli,
and
D.J.Shapiro
(1992).
Binding of the estrogen receptor DNA-binding domain to the estrogen response element induces DNA bending.
|
| |
Mol Cell Biol,
12,
2037-2042.
|
|
|
|
|
|
|
D.Metzger,
R.Losson,
J.M.Bornert,
Y.Lemoine,
and
P.Chambon
(1992).
Promoter specificity of the two transcriptional activation functions of the human oestrogen receptor in yeast.
|
| |
Nucleic Acids Res,
20,
2813-2817.
|
|
|
|
|
|
|
D.N.Danforth
(1992).
Hormone receptors in malignancy.
|
| |
Crit Rev Oncol Hematol,
12,
91.
|
|
|
|
|
|
|
E.A.Golemis,
and
R.Brent
(1992).
Fused protein domains inhibit DNA binding by LexA.
|
| |
Mol Cell Biol,
12,
3006-3014.
|
|
|
|
|
|
|
E.R.Kellenbach,
M.L.Remerowski,
D.Eib,
R.Boelens,
G.A.van der Marel,
H.van den Elst,
J.H.van Boom,
and
R.Kaptein
(1992).
Synthesis of isotope labeled oligonucleotides and their use in an NMR study of a protein-DNA complex.
|
| |
Nucleic Acids Res,
20,
653-657.
|
|
|
|
|
|
|
H.Klocker,
F.Kaspar,
J.Eberle,
S.Uberreiter,
C.Radmayr,
and
G.Bartsch
(1992).
Point mutation in the DNA binding domain of the androgen receptor in two families with Reifenstein syndrome.
|
| |
Am J Hum Genet,
50,
1318-1327.
|
|
|
|
|
|
|
I.Alroy,
and
L.P.Freedman
(1992).
DNA binding analysis of glucocorticoid receptor specificity mutants.
|
| |
Nucleic Acids Res,
20,
1045-1052.
|
|
|
|
|
|
|
I.Cosic,
and
M.T.Hearn
(1992).
Studies on protein-DNA interactions using the resonant recognition model. Application to repressors and transforming proteins.
|
| |
Eur J Biochem,
205,
613-619.
|
|
|
|
|
|
|
J.A.Tainer,
V.A.Roberts,
and
E.D.Getzoff
(1992).
Protein metal-binding sites.
|
| |
Curr Opin Biotechnol,
3,
378-387.
|
|
|
|
|
|
|
J.G.Kim,
and
L.D.Hudson
(1992).
Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene.
|
| |
Mol Cell Biol,
12,
5632-5639.
|
|
|
|
|
|
|
J.J.Hayes,
and
A.P.Wolffe
(1992).
The interaction of transcription factors with nucleosomal DNA.
|
| |
Bioessays,
14,
597-603.
|
|
|
|
|
|
|
J.W.Schwabe
(1992).
DNA between the sheets.
|
| |
Curr Biol,
2,
661-663.
|
|
|
|
|
|
|
M.A.Hirst,
L.Hinck,
M.Danielsen,
and
G.M.Ringold
(1992).
Discrimination of DNA response elements for thyroid hormone and estrogen is dependent on dimerization of receptor DNA binding domains.
|
| |
Proc Natl Acad Sci U S A,
89,
5527-5531.
|
|
|
|
|
|
|
M.B.Diccianni,
M.Imagawa,
and
M.Muramatsu
(1992).
The dyad palindromic glutathione transferase P enhancer binds multiple factors including AP1.
|
| |
Nucleic Acids Res,
20,
5153-5158.
|
|
|
|
|
|
|
M.F.Summers,
L.E.Henderson,
M.R.Chance,
J.W.Bess,
T.L.South,
P.R.Blake,
I.Sagi,
G.Perez-Alvarado,
R.C.Sowder,
and
D.R.Hare
(1992).
Nucleocapsid zinc fingers detected in retroviruses: EXAFS studies of intact viruses and the solution-state structure of the nucleocapsid protein from HIV-1.
|
| |
Protein Sci,
1,
563-574.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.H.Allen,
and
T.W.Hutchens
(1992).
Electrospray-ionization mass spectrometry for the detection of discrete peptide/metal-ion complexes involving multiple cysteine (sulfur) ligands.
|
| |
Rapid Commun Mass Spectrom,
6,
308-312.
|
|
|
|
|
|
|
M.L.Privalsky
(1992).
v-erb A, nuclear hormone receptors, and oncogenesis.
|
| |
Biochim Biophys Acta,
1114,
51-62.
|
|
|
|
|
|
|
M.Leid,
P.Kastner,
R.Lyons,
H.Nakshatri,
M.Saunders,
T.Zacharewski,
J.Y.Chen,
A.Staub,
J.M.Garnier,
and
S.Mader
(1992).
Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
|
| |
Cell,
68,
377-395.
|
|
|
|
|
|
|
M.R.Koelle,
W.A.Segraves,
and
D.S.Hogness
(1992).
DHR3: a Drosophila steroid receptor homolog.
|
| |
Proc Natl Acad Sci U S A,
89,
6167-6171.
|
|
|
|
|
|
|
M.S.Marks,
P.L.Hallenbeck,
T.Nagata,
J.H.Segars,
E.Appella,
V.M.Nikodem,
and
K.Ozato
(1992).
H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes.
|
| |
EMBO J,
11,
1419-1435.
|
|
|
|
|
|
|
M.Truss,
J.Bartsch,
G.Chalepakis,
and
M.Beato
(1992).
Artificial steroid hormone response element generated by dam-methylation.
|
| |
Nucleic Acids Res,
20,
1483-1486.
|
|
|
|
|
|
|
P.F.Halloran
(1992).
Four decades of glucocorticosteroid immunosuppression.
|
| |
CMAJ,
147,
613-614.
|
|
|
|
|
|
|
P.L.Hallenbeck,
M.S.Marks,
R.E.Lippoldt,
K.Ozato,
and
V.M.Nikodem
(1992).
Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXR beta) enhances DNA binding and TH-dependent transcriptional activation.
|
| |
Proc Natl Acad Sci U S A,
89,
5572-5576.
|
|
|
|
|
|
|
P.S.Danielian,
R.White,
J.A.Lees,
and
M.G.Parker
(1992).
Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.
|
| |
EMBO J,
11,
1025-1033.
|
|
|
|
|
|
|
P.Tran,
X.K.Zhang,
G.Salbert,
T.Hermann,
J.M.Lehmann,
and
M.Pfahl
(1992).
COUP orphan receptors are negative regulators of retinoic acid response pathways.
|
| |
Mol Cell Biol,
12,
4666-4676.
|
|
|
|
|
|
|
R.Baltz,
C.Domon,
D.T.Pillay,
and
A.Steinmetz
(1992).
Characterization of a pollen-specific cDNA from sunflower encoding a zinc finger protein.
|
| |
Plant J,
2,
713-721.
|
|
|
|
|
|
|
R.E.Harrington
(1992).
DNA curving and bending in protein-DNA recognition.
|
| |
Mol Microbiol,
6,
2549-2555.
|
|
|
|
|
|
|
R.K.Hall,
D.K.Scott,
E.L.Noisin,
P.C.Lucas,
and
D.K.Granner
(1992).
Activation of the phosphoenolpyruvate carboxykinase gene retinoic acid response element is dependent on a retinoic acid receptor/coregulator complex.
|
| |
Mol Cell Biol,
12,
5527-5535.
|
|
|
|
|
|
|
S.Kato,
L.Tora,
J.Yamauchi,
S.Masushige,
M.Bellard,
and
P.Chambon
(1992).
A far upstream estrogen response element of the ovalbumin gene contains several half-palindromic 5'-TGACC-3' motifs acting synergistically.
|
| |
Cell,
68,
731-742.
|
|
|
|
|
|
|
T.H.Bestor
(1992).
Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.
|
| |
EMBO J,
11,
2611-2617.
|
|
|
|
|
|
|
T.H.Bugge,
J.Pohl,
O.Lonnoy,
and
H.G.Stunnenberg
(1992).
RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors.
|
| |
EMBO J,
11,
1409-1418.
|
|
|
|
|
|
|
T.Perlmann
(1992).
Glucocorticoid receptor DNA-binding specificity is increased by the organization of DNA in nucleosomes.
|
| |
Proc Natl Acad Sci U S A,
89,
3884-3888.
|
|
|
|
|
|
|
V.C.Yu,
A.M.Näär,
and
M.G.Rosenfeld
(1992).
Transcriptional regulation by the nuclear receptor superfamily.
|
| |
Curr Opin Biotechnol,
3,
597-602.
|
|
|
|
|
|
|
C.K.Glass,
J.DiRenzo,
R.Kurokawa,
and
Z.H.Han
(1991).
Regulation of gene expression by retinoic acid receptors.
|
| |
DNA Cell Biol,
10,
623-638.
|
|
|
|
|
|
|
D.K.Lee,
M.Horikoshi,
and
R.G.Roeder
(1991).
Interaction of TFIID in the minor groove of the TATA element.
|
| |
Cell,
67,
1241-1250.
|
|
|
|
|
|
|
R.Kaptein
(1991).
Distinguishing features.
|
| |
Curr Biol,
1,
336-338.
|
|
|
|
|
|
|
V.C.Yu,
C.Delsert,
B.Andersen,
J.M.Holloway,
O.V.Devary,
A.M.Näär,
S.Y.Kim,
J.M.Boutin,
C.K.Glass,
and
M.G.Rosenfeld
(1991).
RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements.
|
| |
Cell,
67,
1251-1266.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
|
|
Links
