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PDBsum entry 1exb
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protein ligands Protein-protein interface(s) links
Metal transport PDB id
1exb

 

 

 

 

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Contents
Protein chains
326 a.a. *
91 a.a. *
Ligands
NDP
Waters ×266
* Residue conservation analysis
PDB id:
1exb
Name: Metal transport
Title: Structure of the cytoplasmic beta subunit-t1 assembly of voltage- dependent k channels
Structure: Kv beta2 protein. Chain: a. Fragment: beta subunit, residues 36-367. Engineered: yes. Potassium channel kv1.1. Chain: e. Fragment: t1 domain, residues 27-129. Engineered: yes
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: brain. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Biol. unit: Octamer (from PDB file)
Resolution:
2.10Å     R-factor:   0.215     R-free:   0.227
Authors: J.M.Gulbis,M.Zhou,S.Mann,R.Mackinnon
Key ref:
J.M.Gulbis et al. (2000). Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science, 289, 123-127. PubMed id: 10884227 DOI: 10.1126/science.289.5476.123
Date:
02-May-00     Release date:   19-Jul-00    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P62483  (KCAB2_RAT) -  Voltage-gated potassium channel subunit beta-2 from Rattus norvegicus
Seq:
Struc: 		367 a.a.
326 a.a.
Protein chain
Pfam   ArchSchema ?
P10499  (KCNA1_RAT) -  Potassium voltage-gated channel subfamily A member 1 from Rattus norvegicus
Seq:
Struc: 		495 a.a.
91 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 1: Chain A: E.C.1.1.1.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
   Enzyme class 2: Chain E: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

 

 
DOI no: 10.1126/science.289.5476.123 Science 289:123-127 (2000)
PubMed id: 10884227  
 
 
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels.
J.M.Gulbis, M.Zhou, S.Mann, R.MacKinnon.
 
  ABSTRACT  
 
The structure of the cytoplasmic assembly of voltage-dependent K+ channels was solved by x-ray crystallography at 2.1 angstrom resolution. The assembly includes the cytoplasmic (T1) domain of the integral membrane alpha subunit together with the oxidoreductase beta subunit in a fourfold symmetric T1(4)beta4 complex. An electrophysiological assay showed that this complex is oriented with four T1 domains facing the transmembrane pore and four beta subunits facing the cytoplasm. The transmembrane pore communicates with the cytoplasm through lateral, negatively charged openings above the T1(4)beta4 complex. The inactivation peptides of voltage-dependent K(+) channels reach their site of action by entering these openings.
 
  Selected figure(s)  
 
Figure 1.
Fig. 1. Structure of the T1[4] [4] complex. (A) Ribbon representation showing four contact loops that form the primary interface between the T1 and tetramers. The T1 tetramer is red and the tetramer is blue. (B) Molecular detail of a T1 contact loop touching the subunit surface (24). (C) Stereoview of a C trace of the tetramer (blue) and T1 tetramer (red) viewed along the four-fold axis and showing the relative proximity of the NH[2]-termini of each where inactivation gates are attached. The NADP+ cofactor in each active site is green. This figure was generated with the programs O (25), MOLSCRIPT (26), Raster-3D (27), and POVRAY (28). 		Figure 5.
Fig. 5. Composite model of a voltage-dependent K+ channel. The subunit is shown in red, and the subunit is in blue. The model of the pore region is based on the KcsA K+ channel (30). The structures of the voltage-sensing region and connectors are unknown (depicted schematically). An NH[2]-terminal inactivation peptide is shown entering a lateral opening to gain access to the pore. Proposed locations of amino acids 273 to 275 on the T1-S1 linker are shown (black asterisks) with the location of Val247 on the T1 domain surface (green asterisks).
 
  The above figures are reprinted by permission from the AAAs: Science (2000, 289, 123-127) copyright 2000.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
21357749 H.Vacher, J.W.Yang, O.Cerda, A.Autillo-Touati, B.Dargent, and J.S.Trimmer (2011).
Cdk-mediated phosphorylation of the Kv{beta}2 auxiliary subunit regulates Kv1 channel axonal targeting.
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21159668 U.Ravens, and E.Wettwer (2011).
Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications.
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21436029 Y.Pan, J.Weng, E.J.Levin, and M.Zhou (2011).
Oxidation of NADPH on Kvbeta1 inhibits ball-and-chain type inactivation by restraining the chain.
  Proc Natl Acad Sci U S A, 108, 5885-5890.  
19619557 N.Niwa, and J.M.Nerbonne (2010).
Molecular determinants of cardiac transient outward potassium current (I(to)) expression and regulation.
  J Mol Cell Cardiol, 48, 12-25.  
19690160 A.Lvov, D.Greitzer, S.Berlin, D.Chikvashvili, S.Tsuk, I.Lotan, and I.Michaelevski (2009).
Rearrangements in the relative orientation of cytoplasmic domains induced by a membrane-anchored protein mediate modulations in Kv channel gating.
  J Biol Chem, 284, 28276-28291.  
  19528261 A.Prince-Carter, and P.J.Pfaffinger (2009).
Multiple intermediate states precede pore block during N-type inactivation of a voltage-gated potassium channel.
  J Gen Physiol, 134, 15-34.  
18836841 A.V.Pischalnikova, and O.S.Sokolova (2009).
The domain and conformational organization in potassium voltage-gated ion channels.
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19113860 C.A.Ahern, and W.R.Kobertz (2009).
Chemical tools for K(+) channel biology.
  Biochemistry, 48, 517-526.  
18607586 D.Wray (2009).
Intracellular regions of potassium channels: Kv2.1 and heag.
  Eur Biophys J, 38, 285-292.  
19028475 L.Di Costanzo, T.M.Penning, and D.W.Christianson (2009).
Aldo-keto reductases in which the conserved catalytic histidine is substituted.
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19521339 Y.Haitin, R.Wiener, D.Shaham, A.Peretz, E.B.Cohen, L.Shamgar, O.Pongs, J.A.Hirsch, and B.Attali (2009).
Intracellular domains interactions and gated motions of I(KS) potassium channel subunits.
  EMBO J, 28, 1994-2005.  
  19237592 Z.Zhang, X.H.Zeng, X.M.Xia, and C.J.Lingle (2009).
N-terminal inactivation domains of beta subunits are protected from trypsin digestion by binding within the antechamber of BK channels.
  J Gen Physiol, 133, 263-282.  
18542995 A.Lvov, D.Chikvashvili, I.Michaelevski, and I.Lotan (2008).
VAMP2 interacts directly with the N terminus of Kv2.1 to enhance channel inactivation.
  Pflugers Arch, 456, 1121-1136.  
18364354 H.Soh, and S.A.Goldstein (2008).
I SA channel complexes include four subunits each of DPP6 and Kv4.2.
  J Biol Chem, 283, 15072-15077.  
  18923186 H.Vacher, D.P.Mohapatra, and J.S.Trimmer (2008).
Localization and targeting of voltage-dependent ion channels in mammalian central neurons.
  Physiol Rev, 88, 1407-1447.  
17981906 J.Barghaan, M.Tozakidou, H.Ehmke, and R.Bähring (2008).
Role of N-terminal domain and accessory subunits in controlling deactivation-inactivation coupling of Kv4.2 channels.
  Biophys J, 94, 1276-1294.  
18415675 K.Wang (2008).
Modulation by clamping: Kv4 and KChIP interactions.
  Neurochem Res, 33, 1964-1969.  
18357523 M.Covarrubias, A.Bhattacharji, J.A.De Santiago-Castillo, K.Dougherty, Y.A.Kaulin, T.R.Na-Phuket, and G.Wang (2008).
The neuronal Kv4 channel complex.
  Neurochem Res, 33, 1558-1567.  
18959476 M.M.Kuo, I.Maslennikov, B.Molden, and S.Choe (2008).
The desensitization gating of the MthK K+ channel is governed by its cytoplasmic amino terminus.
  PLoS Biol, 6, e223.  
18987637 N.Decher, T.Gonzalez, A.K.Streit, F.B.Sachse, V.Renigunta, M.Soom, S.H.Heinemann, J.Daut, and M.C.Sanguinetti (2008).
Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2.
  EMBO J, 27, 3164-3174.  
18949601 O.A.Barski, S.M.Tipparaju, and A.Bhatnagar (2008).
The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.
  Drug Metab Rev, 40, 553-624.  
18668522 R.Martínez-Mármol, N.Villalonga, L.Solé, R.Vicente, M.M.Tamkun, C.Soler, and A.Felipe (2008).
Multiple Kv1.5 targeting to membrane surface microdomains.
  J Cell Physiol, 217, 667-673.  
18936745 S.C.Kohout, and E.Y.Isacoff (2008).
To dislodge an enzyme from an ion channel, try steroids.
  Nat Chem Biol, 4, 650-651.  
18672894 S.M.Tipparaju, O.A.Barski, S.Srivastava, and A.Bhatnagar (2008).
Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel.
  Biochemistry, 47, 8840-8854.  
18541528 T.J.Morin, and W.R.Kobertz (2008).
Tethering chemistry and K+ channels.
  J Biol Chem, 283, 25105-25109.  
18782578 Y.Fujiwara, and D.L.Minor (2008).
X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil.
  J Mol Biol, 383, 854-870.
PDB code: 3e7k
18806782 Y.Pan, J.Weng, V.Kabaleeswaran, H.Li, Y.Cao, R.C.Bhosle, and M.Zhou (2008).
Cortisone dissociates the Shaker family K+ channels from their beta subunits.
  Nat Chem Biol, 4, 708-714.
PDB codes: 3eau 3eb3 3eb4
18222921 Y.Pan, J.Weng, Y.Cao, R.C.Bhosle, and M.Zhou (2008).
Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1.
  J Biol Chem, 283, 8634-8642.  
18974836 Z.Frankenstein, J.Sperling, R.Sperling, and M.Eisenstein (2008).
FitEM2EM--tools for low resolution study of macromolecular assembly and dynamics.
  PLoS ONE, 3, e3594.  
19016844 Z.Yuchi, V.P.Pau, and D.S.Yang (2008).
GCN4 enhances the stability of the pore domain of potassium channel KcsA.
  FEBS J, 275, 6228-6236.  
17605815 A.M.Burroughs, S.Balaji, L.M.Iyer, and L.Aravind (2007).
Small but versatile: the extraordinary functional and structural diversity of the beta-grasp fold.
  Biol Direct, 2, 18.  
17993327 G.W.Abbott, X.Xu, and T.K.Roepke (2007).
Impact of ancillary subunits on ventricular repolarization.
  J Electrocardiol, 40, S42-S46.  
17187064 H.Wang, Y.Yan, Q.Liu, Y.Huang, Y.Shen, L.Chen, Y.Chen, Q.Yang, Q.Hao, K.Wang, and J.Chai (2007).
Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits.
  Nat Neurosci, 10, 32-39.
PDB code: 2nz0
17541769 I.S.Gabashvili, B.H.Sokolowski, C.C.Morton, and A.B.Giersch (2007).
Ion channel gene expression in the inner ear.
  J Assoc Res Otolaryngol, 8, 305-328.  
17261810 M.D.Benson, Q.J.Li, K.Kieckhafer, D.Dudek, M.R.Whorton, R.K.Sunahara, J.A.Iñiguez-Lluhí, and J.R.Martens (2007).
SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.
  Proc Natl Acad Sci U S A, 104, 1805-1810.  
17340113 N.A.Caballero, F.J.Meléndez, A.Niño, and C.Muñoz-Caro (2007).
Molecular docking study of the binding of aminopyridines within the K+ channel.
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17534481 X.Liang, D.J.Campopiano, and P.J.Sadler (2007).
Metals in membranes.
  Chem Soc Rev, 36, 968-992.  
16909197 A.F.Dulhunty, N.A.Beard, P.Pouliquin, and T.Kimura (2006).
Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies.
  J Muscle Res Cell Motil, 27, 351-365.  
16685597 E.D.Burg, C.V.Remillard, and J.X.Yuan (2006).
K+ channels in apoptosis.
  J Membr Biol, 209, 3.  
  16418401 G.R.Benzinger, X.M.Xia, and C.J.Lingle (2006).
Direct observation of a preinactivated, open state in BK channels with beta2 subunits.
  J Gen Physiol, 127, 119-131.  
  16533897 G.Wang, and M.Covarrubias (2006).
Voltage-dependent gating rearrangements in the intracellular T1-T1 interface of a K+ channel.
  J Gen Physiol, 127, 391-400.  
16791144 H.C.Lai, and L.Y.Jan (2006).
The distribution and targeting of neuronal voltage-gated ion channels.
  Nat Rev Neurosci, 7, 548-562.  
16892366 H.Sun (2006).
An accurate and interpretable bayesian classification model for prediction of HERG liability.
  ChemMedChem, 1, 315-322.  
16569641 J.Weng, Y.Cao, N.Moss, and M.Zhou (2006).
Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase.
  J Biol Chem, 281, 15194-15200.  
17156368 P.Imbrici, M.C.D'Adamo, D.M.Kullmann, and M.Pessia (2006).
Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2.
  Eur J Neurosci, 24, 3073-3083.  
16725367 P.Pouliquin, S.M.Pace, S.M.Curtis, P.J.Harvey, E.M.Gallant, F.Zorzato, M.G.Casarotto, and A.F.Dulhunty (2006).
Effects of an alpha-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: modulation by Homer.
  Int J Biochem Cell Biol, 38, 1700-1715.  
16472864 S.I.Judge, and C.T.Bever (2006).
Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment.
  Pharmacol Ther, 111, 224-259.  
16770729 T.Fujita, I.Utsunomiya, J.Ren, Y.Matsushita, M.Kawai, S.Sasaki, K.Hoshi, T.Miyatake, and K.Taguchi (2006).
Glycosylation and cell surface expression of Kv1.2 potassium channel are regulated by determinants in the pore region.
  Neurochem Res, 31, 589-596.  
16504945 U.Schulte, J.O.Thumfart, N.Klöcker, C.A.Sailer, W.Bildl, M.Biniossek, D.Dehn, T.Deller, S.Eble, K.Abbass, T.Wangler, H.G.Knaus, and B.Fakler (2006).
The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.
  Neuron, 49, 697-706.  
16169480 A.Grottesi, Z.A.Sands, and M.S.Sansom (2005).
Potassium channels: complete and undistorted.
  Curr Biol, 15, R771-R774.  
16096338 B.Callsen, D.Isbrandt, K.Sauter, L.S.Hartmann, O.Pongs, and R.Bähring (2005).
Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected]
  J Physiol, 568, 397-412.  
15613396 B.Pierce, W.Tong, and Z.Weng (2005).
M-ZDOCK: a grid-based approach for Cn symmetric multimer docking.
  Bioinformatics, 21, 1472-1478.  
15827117 D.Kerschensteiner, F.Soto, and M.Stocker (2005).
Fluorescence measurements reveal stoichiometry of K+ channels formed by modulatory and delayed rectifier alpha-subunits.
  Proc Natl Acad Sci U S A, 102, 6160-6165.  
  15955876 G.Wang, M.Shahidullah, C.A.Rocha, C.Strang, P.J.Pfaffinger, and M.Covarrubias (2005).
Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels.
  J Gen Physiol, 126, 55-69.  
16262625 J.F.Rivera, P.J.Chu, and D.B.Arnold (2005).
The T1 domain of Kv1.3 mediates intracellular targeting to axons.
  Eur J Neurosci, 22, 1853-1862.  
15664174 J.M.Robinson, and C.Deutsch (2005).
Coupled tertiary folding and oligomerization of the T1 domain of Kv channels.
  Neuron, 45, 223-232.  
16149768 L.B.French, A.Singh, R.Luik, and R.M.Harris-Warrick (2005).
Structural requirements for rapid inactivation and voltage dependence in splice variants of lobster Shaker potassium channels.
  J Recept Signal Transduct Res, 25, 73-97.  
16207353 P.J.Stogios, G.S.Downs, J.J.Jauhal, S.K.Nandra, and G.G.Privé (2005).
Sequence and structural analysis of BTB domain proteins.
  Genome Biol, 6, R82.  
  15618483 S.C.Hebert, G.Desir, G.Giebisch, and W.Wang (2005).
Molecular diversity and regulation of renal potassium channels.
  Physiol Rev, 85, 319-371.  
15816169 S.J.Korn, and J.G.Trapani (2005).
Potassium channels.
  IEEE Trans Nanobioscience, 4, 21-33.  
15473968 A.Kosolapov, L.Tu, J.Wang, and C.Deutsch (2004).
Structure acquisition of the T1 domain of Kv1.3 during biogenesis.
  Neuron, 44, 295-307.  
15357420 B.L.Resendes, S.F.Kuo, N.G.Robertson, A.B.Giersch, D.Honrubia, O.Ohara, J.C.Adams, and C.C.Morton (2004).
Isolation from cochlea of a novel human intronless gene with predominant fetal expression.
  J Assoc Res Otolaryngol, 5, 185-202.  
15313238 J.M.Gulbis, and D.A.Doyle (2004).
Potassium channel structures: do they conform?
  Curr Opin Struct Biol, 14, 440-446.  
15473959 J.S.Trimmer (2004).
Peering into the birth canal during ion channel parturition.
  Neuron, 44, 214-216.  
15189853 K.Yu, W.Fu, H.Liu, X.Luo, K.X.Chen, J.Ding, J.Shen, and H.Jiang (2004).
Computational simulations of interactions of scorpion toxins with the voltage-gated potassium ion channel.
  Biophys J, 86, 3542-3555.  
14980201 L.A.Kim, J.Furst, D.Gutierrez, M.H.Butler, S.Xu, S.A.Goldstein, and N.Grigorieff (2004).
Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution.
  Neuron, 41, 513-519.  
14695263 M.Gebauer, D.Isbrandt, K.Sauter, B.Callsen, A.Nolting, O.Pongs, and R.Bähring (2004).
N-type inactivation features of Kv4.2 channel gating.
  Biophys J, 86, 210-223.  
14980207 R.H.Scannevin, K.Wang, F.Jow, J.Megules, D.C.Kopsco, W.Edris, K.C.Carroll, Q.Lü, W.Xu, Z.Xu, A.H.Katz, S.Olland, L.Lin, M.Taylor, M.Stahl, K.Malakian, W.Somers, L.Mosyak, M.R.Bowlby, P.Chanda, and K.J.Rhodes (2004).
Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
  Neuron, 41, 587-598.
PDB codes: 1s1e 1s1g
15103137 T.Shimamura, O.Shamotienko, S.Akhtar, J.O.Dolly, and S.Iwata (2004).
Crystallization and preliminary X-ray analysis of pseudo-merohedrally twinned crystals of the full-length beta(2) subunit of the Kv1 K(+) channel from Rattus norvegicus.
  Acta Crystallogr D Biol Crystallogr, 60, 912-914.  
14675526 D.E.Clapham, R.MacKinnon, and P.Agre (2003).
Symmetry, selectivity, and the 2003 Nobel Prize.
  Cell, 115, 641-646.  
14569011 O.Sokolova, A.Accardi, D.Gutierrez, A.Lau, M.Rigney, and N.Grigorieff (2003).
Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.
  Proc Natl Acad Sci U S A, 100, 12607-12612.  
12655069 S.C.Burdette, and S.J.Lippard (2003).
Meeting of the minds: metalloneurochemistry.
  Proc Natl Acad Sci U S A, 100, 3605-3610.  
11826262 C.Deutsch (2002).
Potassium channel ontogeny.
  Annu Rev Physiol, 64, 19-46.  
12214225 G.Yellen (2002).
The voltage-gated potassium channels and their relatives.
  Nature, 419, 35-42.  
12040127 J.Meidanis, M.D.Braga, and S.Verjovski-Almeida (2002).
Whole-genome analysis of transporters in the plant pathogen Xylella fastidiosa.
  Microbiol Mol Biol Rev, 66, 272-299.  
12203387 L.K.Bekar, and W.Walz (2002).
Intracellular chloride modulates A-type potassium currents in astrocytes.
  Glia, 39, 207-216.  
11867445 M.A.Harrington, and R.R.Kopito (2002).
Cysteine residues in the nucleotide binding domains regulate the conductance state of CFTR channels.
  Biophys J, 82, 1278-1292.  
11980705 M.K.Higgins, D.Weitz, T.Warne, G.F.Schertler, and U.B.Kaupp (2002).
Molecular architecture of a retinal cGMP-gated channel: the arrangement of the cytoplasmic domains.
  EMBO J, 21, 2087-2094.  
12507423 M.Nishida, and R.MacKinnon (2002).
Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution.
  Cell, 111, 957-965.
PDB code: 1n9p
11863426 M.R.Hanlon, and B.A.Wallace (2002).
Structure and function of voltage-dependent ion channel regulatory beta subunits.
  Biochemistry, 41, 2886-2894.  
11988468 R.H.Spencer, and D.C.Rees (2002).
The alpha-helix and the organization and gating of channels.
  Annu Rev Biophys Biomol Struct, 31, 207-233.  
12539258 S.Choe, and T.Roosild (2002).
Regulation of the K channels by cytoplasmic domains.
  Biopolymers, 66, 294-299.  
11854493 S.H.Loukin, J.Lin, U.Athar, C.Palmer, and Y.Saimi (2002).
The carboxyl tail forms a discrete functional domain that blocks closure of the yeast K+ channel.
  Proc Natl Acad Sci U S A, 99, 1926-1930.  
12414683 T.Wagenknecht, C.E.Hsieh, B.K.Rath, S.Fleischer, and M.Marko (2002).
Electron tomography of frozen-hydrated isolated triad junctions.
  Biophys J, 83, 2491-2501.  
  11723163 B.L.Moss, and K.L.Magleby (2001).
Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels.
  J Gen Physiol, 118, 711-734.  
  11158168 D.M.Cortes, L.G.Cuello, and E.Perozo (2001).
Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating.
  J Gen Physiol, 117, 165-180.
PDB code: 1f6g
11432987 E.Aydar, and C.Palmer (2001).
Functional characterization of the C-terminus of the human ether-à-go-go-related gene K(+) channel (HERG).
  J Physiol, 534, 1.  
  11524461 H.T.Kurata, G.S.Soon, and D.Fedida (2001).
Altered state dependence of c-type inactivation in the long and short forms of human Kv1.5.
  J Gen Physiol, 118, 315-332.  
  11134230 J.Kurokawa, H.K.Motoike, and R.S.Kass (2001).
TEA(+)-sensitive KCNQ1 constructs reveal pore-independent access to KCNE1 in assembled I(Ks) channels.
  J Gen Physiol, 117, 43-52.  
11286888 O.Sokolova, L.Kolmakova-Partensky, and N.Grigorieff (2001).
Three-dimensional structure of a voltage-gated potassium channel at 2.5 nm resolution.
  Structure, 9, 215-220.  
11306109 S.Q.Liu, H.Jin, A.Zacarias, S.Srivastava, and A.Bhatnagar (2001).
Binding of pyridine coenzymes to the beta-subunit of the voltage sensitive potassium channels.
  Chem Biol Interact, 130, 955-962.  
  11178249 C.Miller (2000).
An overview of the potassium channel family.
  Genome Biol, 1, REVIEWS0004.  
10956024 W.R.Kobertz, C.Williams, and C.Miller (2000).
Hanging gondola structure of the T1 domain in a voltage-gated K(+) channel.
  Biochemistry, 39, 10347-10352.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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