PDBsum entry 1am6

Hydrolase

PDB id: 1am6

Contents

Protein chain

258 a.a. *

Ligands

HAE

Metals

_HG

_ZN

Waters ×113

* Residue conservation analysis

PDB id:

1am6

Name:

Hydrolase

Title:

Carbonic anhydrase ii inhibitor: acetohydroxamate

Structure:

Carbonic anhydrase. Chain: a. Ec: 4.2.1.1

Source:

Homo sapiens. Human. Organism_taxid: 9606. Cell: erythrocytes. Cellular_location: cytoplasm

Resolution:

2.00Å R-factor: 0.160 R-free: 0.220

Authors:

L.R.Scolnick,A.M.Clements,D.W.Christianson

Key ref:

L.R.Scolnick et al. (1997). Novel binding mode of hydroxamate inhibitors to human carbonic anhydrase ii. J am chem soc, 119, 850.

Date:

24-Jun-97 Release date: 24-Jun-98

Protein chain

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 258 a.a.

Enzyme reactions

• Enzyme class 2: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)
• Enzyme class 3: E.C.4.2.1.69 - cyanamide hydratase.
• Reaction: urea = cyanamide + H2O

urea (Bound ligand (Het Group name = HAE) matches with 50.00% similarity) = cyanamide + H2O

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site