PDBsum entry 1al6

Lyase

PDB id: 1al6

Contents

Protein chain

435 a.a. *

Ligands

OAA

HAX

Waters ×143

* Residue conservation analysis

PDB id:

1al6

Name:

Lyase

Title:

Chicken citrate synthase complex with n-hydroxyamido-coa and oxaloacetate

Structure:

Citrate synthase. Chain: a. Ec: 4.1.3.7

Source:

Gallus gallus. Chicken. Organism_taxid: 9031. Cell_line: 293. Organ: heart. Tissue: muscle. Organelle: mitochondrion. Cellular_location: inner matrix

Biol. unit:

Homo-Dimer (from PDB file)

Resolution:

1.85Å R-factor: 0.157

Authors:

K.C.Usher,S.J.Remington

Key ref:

B.Schwartz et al. Mechanisms of enzyme-Catalyzed deprotonation of acetyl-Coenzyme a. To be published, .

Date:

12-Jun-97 Release date: 24-Dec-97

Protein chain

P23007  (CISY_CHICK) -  Citrate synthase, mitochondrial from Gallus gallus

Seq: 433 a.a.

Struc: 435 a.a.*

* PDB and UniProt seqs differ at 31 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.3.1 - citrate (Si)-synthase.
• Pathway: Citric acid cycle
• Reaction: oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H⁺

oxaloacetate + acetyl-CoA + H2O (Bound ligand (Het Group name = OAA) corresponds exactly) = citrate + CoA (Bound ligand (Het Group name = HAX) matches with 88.68% similarity) + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site