Description: The SCOP database, created by manual inspection and abetted by a battery of automated methods, aims to provide a detailed and comprehensive description of the structural and evolutionary relationships between all proteins whose structure is known.

Description: The Pfam database is a large collection of protein families, each represented by multiple sequence alignments and hidden Markov models (HMMs).

Description: InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Description: The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.

Description: The Protein Kinase Ontology (ProKinO), is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

Description: CATH-FunSites are groups of amino acid residues that are evolutionarily conserved within a CATH FunFam, i.e. proteins sharing the same function and hence, are most likely to be functionally important.

Description: ChannelsDB is a comprehensive and regularly updated resource of channels, pores and tunnels found in biomacromolecules deposited in the Protein Data Bank. As such, it is a unique service for channel-related analyses.

Description: canSAR is an integrated knowledge-base that brings together multidisciplinary data across biology, chemistry, pharmacology, structural biology, cellular networks and clinical annotations, and applies machine learning approaches to provide drug-discovery useful predictions.

Description: 3DLigandSite is an automated method for the prediction of ligand binding sites.

Description: M-CSA is a database of enzyme reaction mechanisms. It provides annotation on the protein, catalytic residues, cofactors, and the reaction mechanisms of hundreds of enzymes.

Description: P2Rank is a machine learning based method for prediction of ligand binding sites from protein structure.

Description: Functional annotation of metal-binding sites in 3D structures

Description: Missense3D predicts the structural changes introduced by an amino acid substitution and is applicable to analyse both PDB coordinates and homology-predicted structures.

Description: FoldX provides a fast and quantitative estimation of the importance of the interactions contributing to the stability of proteins and protein complexes.

Description: 14-3-3-Pred is a webserver that predicts 14-3-3-binding sites in proteins by combining predictions from three different classifiers: ANN, PSSM SVM, as wll as a consensus predictor. 14-3-3-Pred provides prediction scores as well as information on the phosphorylation state of the respective Ser/Thr.

Description: Predictions of phosphorylation sites for kinases in target proteins.

Description: CaMKinet is a Calcium/Calmodulin-dependent protein kinases (CaMKs) and their substrates database. CaMKs and their allies constitute a large family of Serine/Threonine kinases.

Description: DynaMine is a fast predictor of protein backbone dynamics using only sequence information as input.

Description: POPSCOMP is a method to analyse interactions between individual complex components of proteins and/or nucleic acids by calculating the solvent accessible surface area (SASA) buried upon complex formation.

Description: Calculations of interatomic interactions in protein structures

Description: Server for computing/predicting depth, cavity sizes, ligand binding sites and pKa

Description: Sequence-based predictions of the residues that start to fold independently in proteins

Description: MobiDB provides consensus intrinsic disorder predictions.