Featured structures

25 Feb 2015Structure of FGFR1 with an inhibitor bound FGFR1 with an inhibitor

PDB 4ux0:
Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. Structures released on 25th February describe insights underpinning the impact of mutations on these proteins on drug efficacy.

The structures are described by Bunney et al. in EBioMedicine doi:10.1016/J.EBIOM.2015.02.009

23 Feb 2015 Human Retinoid X Receptor DNA-Binding Domain Bound to the Human Ramp2 Response Element.

PDB 4cn2:
Signalling by retinoid X receptors control many cellular functions such as embryogenesis, cell growth, differentiation, and apoptosis. This structure, and several others published with it, describe the binding of the receptor to DNA.

Osz et al. Sci. Rep (2015) DOI 10.1038/srep08216