Bringing Structure to Biology
|22 Dec 2015||
You've got the Christmas Factor
There’s an enzyme in humans, called Christmas Factor. It isn’t responsible for filling us with festive cheer, but is one of the enzymes responsible for blood clotting.
|23 Jul 2015||
Solanezumab. An anti-Alzheimer's antibody
Solanezumab, an antibody which may slow the progression of Alzheimer's disease, recognizes a central portion of amyloid beta. Its structure reveals how.
|30 Jun 2015||
Turning a hormone into a weapon
Structures of a venom peptide from distantly related arthropods have revealed that these peptides are evolved convergently from a common ancestral hormone.
|28 May 2015||
New letters in the genetic code
Structures of DNA containing two non-natural nucleotides, termed 'Z' and 'P', have recently been determined. They base pair with a standard Watson-Crick geometry and short lengths of DNA containing this base pair, or several of them, can form both B- and A-form structures.
|09 May 2015||
The more you bind, the less you need
How the different types of MHC molecules you express could affect how you react to a disease.
|08 Apr 2015||
It takes two. HindIII needs two manganese ions at the active site.
The restriction enzyme HindIII is used in probably every molecular biology lab in the world, but recent studies have shed light on how it works.
|25 Mar 2015||
Mupain: Better binding with higher entropy
Mupain is a cyclic peptide which inhibits the serine protease murine urokinase-type plasminogen activator. More flexible forms of mupain bind with a greater affinity to the protease.
|11 Mar 2015||
Structure of a left-handed DNA G-quadruplex.
The iconic double helical structure of B-form DNA needs no introduction, but DNA can take on several different structures too. A new one has entered the PDB this week.
|05 Mar 2015||
Structure of an allergen from surgical gloves
Latex allergy can be a major issue in the healthcare environment and can lead to anaphylactic shock in extreme cases. This study examines how a protein allergen is modified during the manufacturing process of latex products. The structure was determined of an allergen after first purifiying the protein from surgical gloves!
The paper is published in Molecular Immunology by Galicia et al. 10.1016/j.molimm.2015.01.018
|27 Feb 2015||
Cryo-EM structure of the Dark apoptosome.
This apoptosome structure was solved by cryo-EM at 4Å resolution and, along with the atomic model fitted into the map, is published by Pang et al. in Genes & Development. 10.1101/gad.255877.11