Featured structures

22 Dec 2015Structure of porcine Christmas Factor You've got the Christmas Factor

There’s an enzyme in humans, called Christmas Factor. It isn’t responsible for filling us with festive cheer, but is one of the enzymes responsible for blood clotting.
23 Jul 2015Schematic diagram of Solanezumab bound to amyloid beta peptide Solanezumab. An anti-Alzheimer's antibody

Solanezumab, an antibody which may slow the progression of Alzheimer's disease, recognizes a central portion of amyloid beta. Its structure reveals how.
30 Jun 2015Centipede with centipede and spider toxins overlayed Turning a hormone into a weapon

Structures of a venom peptide from distantly related arthropods have revealed that these peptides are evolved convergently from a common ancestral hormone.
28 May 2015Stick diagram of a Z-P base pair New letters in the genetic code

Structures of DNA containing two non-natural nucleotides, termed 'Z' and 'P',  have recently been determined. They base pair with a standard Watson-Crick geometry and short lengths of DNA containing this base pair, or several of them, can form both B- and A-form structures. 
09 May 2015Peptide (shown as sticks) bound to a chicken MHC The more you bind, the less you need

How the different types of MHC molecules you express could affect how you react to a disease.
08 Apr 2015Cartoon diagram of a HindIII dimer with bound DNA It takes two. HindIII needs two manganese ions at the active site.

The restriction enzyme HindIII is used in probably every molecular biology lab in the world, but recent studies have shed light on how it works.
25 Mar 2015 Mupain: Better binding with higher entropy

Mupain is a cyclic peptide which inhibits the serine protease murine urokinase-type plasminogen activator. More flexible forms of mupain bind with a greater affinity to the protease.
11 Mar 2015A left-handed DNA G-quadruplex. PDB entry 4u5m Structure of a left-handed DNA G-quadruplex.

The iconic double helical structure of B-form DNA needs no introduction, but DNA can take on several different structures too. A new one has entered the PDB this week.
05 Mar 2015Structure of a latex allergen Structure of an allergen from surgical gloves

PDB 4wp4:

Latex allergy can be a major issue in the healthcare environment and can lead to anaphylactic shock in extreme cases. This study examines how a protein allergen is modified during the manufacturing process of latex products. The structure was determined of an allergen after first purifiying the protein from surgical gloves! 

The paper is published in Molecular Immunology by Galicia et al. 10.1016/j.molimm.2015.01.018

27 Feb 2015Cryo-EM structure of the Dark apoptosome. Cryo-EM structure of the Dark apoptosome.

EMDB EMD-2871:
The apoptosome, which comprises 16 molecules of the Dark protein, facilitates autocatalytic activation of caspase, which starts the process of apoptosis, or cell death.

This apoptosome structure was solved by cryo-EM at 4Å resolution and, along with the atomic model fitted into the map, is published by Pang et al. in Genes & Development. 10.1101/gad.255877.11

Pages