Featured structures

01 Apr 2018PDBe calendar image for April 2018. Zika virus as monomer and full viral capsid. Viruses: Engineering on the nanoscale

The image for April in our 2018 calendar depicts a single Zika virus protein in addition to the full Zika virus capsid. In this feature we discuss the transition between these two structures and demonstrate the beautiful simplicity of virus assembly.

13 Mar 2018Robot next to protein dimer Gin, with a twist

Much like a food mixer, with interchangeable tools that render it suitable for whipping, beating or liquidising, bacterial RNA polymerase has an exchangeable subunit called a sigma factor which adapts it to different programmes of gene expression. Sigma factors are controlled by other proteins called anti-sigma factors, to make sure the polymerase doesn’t whip when it should be liquidising.

01 Mar 2018PDBe calendar image for March 2018. Bacterial pilus with PilT motor protein complex. A powerful little motor

The image for March in our 2018 calendar shows a pathogenic bacterium, the structures that enable it to interact with the environment, and the powerful molecular motor that drives those structures.

01 Feb 2018Poliovirus in intaglio print Polio- A resolution to eradicate

The near-eradication of poliomyelitis is one of the great success stories of modern medicine. The image in our 2018 calendar for February shows the virus which causes it, and highlights one of the amazing developments in modern structural biology.

01 Jan 2018HIV glycoprotein art HIV Glycoprotein

It is estimated that around 37 million people are living with an HIV infection. The molecule on the surface of HIV that recognises host cells and enables the virus to get inside them is depicted in our calendar image for January.

01 Dec 2017Cytochrome P450 shown on the opening flower of the cinchona tree Quinine: Barking up the right tree

The final image in our 2017 calendar shows an important enzyme along with the plant that produces one of its best known substrates. You might drink some if you have a Christmas G&T.

01 Nov 2017Ribosomes in action Making Protein

The human genome codes for 20-25,000 proteins. The lab workhorse bacterium, E.coli, codes for around 2,300. Every single one of those proteins is produced by the huge molecular machine shown on our 2017 calendar image for November.

01 Oct 2017Farnesoid X receptor shown in spheres, with an ivermectin molecule bound Opening a Gate to Human Health

In the 1970s, an exciting discovery of a family of medicines was made by the Japanese scientist Satoshi Ōmura. It is one of these molecules which features in the October image in our 2017 calendar.

01 Sep 2017Calendar artwork depicting the thioredoxin structure overlaid onto the image of a snail Thioredoxin - a small protein with a radical role

This month’s featured structure is that of Thioredoxin, a small protein with a vital role in many organisms.

01 Aug 2017Painting of protein Turning cartwheels

The image from our 2017 calendar for August is inspired by a molecular cartwheel which is essential for the mobility of single celled parasites called trypanosomes. Trypanosomes are the causative agents of several potentially fatal human diseases, including Leishmaniasis, Chagas disease and Sleeping Sickness.