› 8w41

Electron Microscopy
3.54Å resolution

Cryo-EM structure of Myosin VI in the autoinhibited state

Released:
DOI: 10.2210/pdb8w41/pdb
PDB entry 8w41 coloured by chain, front view.
PDB entry 8w41 coloured by chain, side view.
PDB entry 8w41 coloured by chain, top view.
Source organisms:
Primary publication:
Autoinhibition and activation of myosin VI revealed by its cryo-EM structure
Niu F, Li L, Wang L, Xiao J, Xu S, Liu Y, Lin L, Yu C, Wei Z
Nat Commun 15 1187- (2024)
Related structures: EMD-37260

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-240217 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin-1 Chains: B, I
Molecule details ›
Chains: B, I
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DP26 (Residues: 1-149; Coverage: 100%)
Gene names: Calm, Calm1, Cam, Cam1
Sequence domains: EF-hand domain pair
Unconventional myosin-VI Chain: A
Molecule details ›
Chain: A
Length: 1285 amino acids
Theoretical weight: 148.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UM54 (Residues: 1-1294; Coverage: 99%)
Gene names: KIAA0389, MYO6
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand CA 4 x CA
Ligand ADP 1 x ADP
Ligand MG 1 x MG
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.54Å
Relevant EMDB volumes: EMD-37260
Expression system: Homo sapiens

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