› 8uxf

Electron Microscopy
3.13Å resolution

Structure of PKA phosphorylated human RyR2-R420W in the primed state

Released:
DOI: 10.2210/pdb8uxf/pdb
PDB entry 8uxf coloured by chain, front view.
PDB entry 8uxf coloured by chain, side view.
PDB entry 8uxf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Miotto MC, Marks AR
Related structures: EMD-42762

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159297 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ryanodine receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 4967 amino acids
Theoretical weight: 565.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92736 (Residues: 1-4967; Coverage: 100%)
Gene name: RYR2
Sequence domains:
Peptidyl-prolyl cis-trans isomerase FKBP1B Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 108 amino acids
Theoretical weight: 11.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68106 (Residues: 1-108; Coverage: 100%)
Gene names: FKBP12.6, FKBP1B, FKBP1L, FKBP9, OTK4
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase

Ligands and Environments

2 bound ligands:
Ligand ZN 4 x ZN
Ligand ATP 8 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.13Å
Relevant EMDB volumes: EMD-42762
Expression systems:
  • Homo sapiens
  • Escherichia coli

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