› 8hwe

Electron Microscopy
3.3Å resolution

Cryo-EM Structure of D5 ATP-ADP form

Released:
DOI: 10.2210/pdb8hwe/pdb
PDB entry 8hwe coloured by chain, front view.
PDB entry 8hwe coloured by chain, side view.
PDB entry 8hwe coloured by chain, top view.
Source organism: Monkeypox virus
Primary publication:
Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus.
Li Y, Zhu J, Guo Y, Yan R
Nat Struct Mol Biol (2024)
PMID: 38177671
Related structures: EMD-35055

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243321 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uncoating factor OPG117 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 785 amino acids
Theoretical weight: 90.48 KDa
Source organism: Monkeypox virus
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A7H0DN89 (Residues: 1-785; Coverage: 100%)
Gene names: MPXVgp100, OPG117
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ATP 5 x ATP
Ligand MG 5 x MG
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-35055
Expression system: Homo sapiens

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