8gq5

Electron Microscopy
2.7Å resolution

Human SARM1 bounded with NMN and Nanobody-C6, double-layer structure

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 32-mer (preferred)
PDBe Complex ID:
PDB-CPX-226286 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD(+) hydrolase SARM1 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 724 amino acids
Theoretical weight: 79.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6SZW1 (Residues: 1-724; Coverage: 100%)
Gene names: KIAA0524, SAMD2, SARM, SARM1
Sequence domains:
Nanobody C6 Chains: a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p
Molecule details ›
Chains: a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p
Length: 119 amino acids
Theoretical weight: 13.17 KDa
Source organism: Vicugna pacos
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.7Å
Relevant EMDB volumes: EMD-34198
Expression system: Homo sapiens