› 8f2u

Electron Microscopy
3.53Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
PDBe Complex ID:
PDB-CPX-216247 (preferred)
Entry contents:
12 distinct polypeptide molecules
Macromolecules (12 distinct):
COMM domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 190 amino acids
Theoretical weight: 21.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q8N668 (Residues: 1-190; Coverage: 100%)
Gene names: C2orf5, COMMD1, MURR1
Sequence domains:
COMM domain-containing protein 2 Chain: B
Molecule details ›
Chain: B
Length: 199 amino acids
Theoretical weight: 22.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q86X83 (Residues: 1-199; Coverage: 100%)
Gene names: COMMD2, HSPC042, My004
Sequence domains: COMM domain
COMM domain-containing protein 3 Chain: C
Molecule details ›
Chain: C
Length: 195 amino acids
Theoretical weight: 22.18 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9UBI1 (Residues: 1-195; Coverage: 100%)
Gene names: BUP, C10orf8, COMMD3
Sequence domains: COMM domain
COMM domain-containing protein 4 Chain: D
Molecule details ›
Chain: D
Length: 199 amino acids
Theoretical weight: 21.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9H0A8 (Residues: 1-199; Coverage: 100%)
Gene name: COMMD4
Sequence domains:
COMM domain-containing protein 5 Chain: E
Molecule details ›
Chain: E
Length: 260 amino acids
Theoretical weight: 28.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9GZQ3 (Residues: 1-224; Coverage: 100%)
Gene names: COMMD5, HT002
Sequence domains:
COMM domain-containing protein 6 Chain: F
Molecule details ›
Chain: F
Length: 85 amino acids
Theoretical weight: 9.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q7Z4G1 (Residues: 1-85; Coverage: 100%)
Gene names: COMMD6, MSTP076
Sequence domains: COMM domain
COMM domain-containing protein 7 Chain: G
Molecule details ›
Chain: G
Length: 200 amino acids
Theoretical weight: 22.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q86VX2 (Residues: 1-200; Coverage: 100%)
Gene names: C20orf92, COMMD7
Sequence domains:
COMM domain-containing protein 8 Chain: H
Molecule details ›
Chain: H
Length: 183 amino acids
Theoretical weight: 21.12 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9NX08 (Residues: 1-183; Coverage: 100%)
Gene names: COMMD8, MDS022
Sequence domains: COMM domain
COMM domain-containing protein 9 Chain: I
Molecule details ›
Chain: I
Length: 198 amino acids
Theoretical weight: 21.84 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9P000 (Residues: 1-198; Coverage: 100%)
Gene names: COMMD9, HSPC166
Sequence domains:
COMM domain-containing protein 10 Chain: J
Molecule details ›
Chain: J
Length: 212 amino acids
Theoretical weight: 24.38 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q9Y6G5 (Residues: 1-202; Coverage: 100%)
Gene names: COMMD10, HSPC305, PTD002
Sequence domains:
Coiled-coil domain-containing protein 93 Chain: N
Molecule details ›
Chain: N
Length: 631 amino acids
Theoretical weight: 73.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: Q567U6 (Residues: 1-631; Coverage: 100%)
Gene name: CCDC93
Sequence domains:
Coiled-coil domain-containing protein 22 Chain: T
Molecule details ›
Chain: T
Length: 627 amino acids
Theoretical weight: 70.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera
UniProt:
  • Canonical: O60826 (Residues: 1-627; Coverage: 100%)
Gene names: CCDC22, CXorf37, JM1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.53Å
Relevant EMDB volumes: EMD-28827
Expression system: Spodoptera

Quick links

Citations

1 review citation

The PDLIM family of actin-associated proteins and their emerging role in membrane trafficking.
Healy et al. (2023)
2 other articles

1 mention without citation

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome.
Healy et al. (2023)