› 8ez6

X-ray diffraction
2Å resolution

The DBC1/SIRT1 Interaction is Choreographed by Post-translational Modification

Released:
DOI: 10.2210/pdb8ez6/pdb
PDB entry 8ez6 coloured by chain, front view.
PDB entry 8ez6 coloured by chain, side view.
PDB entry 8ez6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification.
Krzysiak TC, Choi YJ, Kim YJ, Yang Y, DeHaven C, Thompson L, Ponticelli R, Mermigos MM, Thomas L, Marquez A, Sipula I, Kemper JK, Jurczak M, Thomas G, Gronenborn AM
Protein Sci 33 e4938 (2024)
PMID: 38533551

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-242376 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell cycle and apoptosis regulator protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 72 amino acids
Theoretical weight: 8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N163 (Residues: 52-120; Coverage: 8%)
Gene names: CCAR2, DBC1, KIAA1967
Sequence domains: S1-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 37.388Å b: 50.822Å c: 62.066Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.238
Expression system: Escherichia coli

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