› 8e1q

X-ray diffraction
2.5Å resolution

The crystal structure of the I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023044

Released:
DOI: 10.2210/pdb8e1q/pdb
PDB 8e1q coloured by chain and viewed from the front.
PDB 8e1q coloured by chain and viewed from the side.
PDB 8e1q coloured by chain and viewed from the top.
Source organism: Influenza A virus (A/Luxembourg/43/2009(H1N1))
Entry authors: Cuypers MG, Slavish JP, Rankovic Z, White SW

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein PA-X Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 23.14 KDa
Source organism: Influenza A virus (A/Luxembourg/43/2009(H1N1))
Expression system: Escherichia coli
UniProt:
  • Canonical: C6H0Y9 (Residues: 1-50, 73-196; Coverage: 43%)
Gene name: PA
Sequence domains: Influenza RNA-dependent RNA polymerase subunit PA

Ligands and Environments

4 bound ligands:
Ligand MN 2 x MN
Ligand U0I 1 x U0I
Ligand QQ4 1 x QQ4
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I422
Unit cell:
a: 88.837Å b: 88.837Å c: 133.209Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.227 0.263
Expression system: Escherichia coli

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