8dm4

Electron Microscopy
2.45Å resolution

Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with Fab 4A8 (focused refinement of NTD and 4A8)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-225311 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 1285 amino acids
Theoretical weight: 142.44 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
Fab 4A8 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 258 amino acids
Theoretical weight: 27.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab 4A8 light chain Chain: L
Molecule details ›
Chain: L
Length: 238 amino acids
Theoretical weight: 25.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.45Å
Relevant EMDB volumes: EMD-27526
Expression system: Homo sapiens