› 8ddv

Electron Microscopy
3.2Å resolution

Cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state4

Released:
DOI: 10.2210/pdb8ddv/pdb
PDB entry 8ddv coloured by chain, front view.
PDB entry 8ddv coloured by chain, side view.
PDB entry 8ddv coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and functional analyses of a GPCR-inhibited ion channel TRPM3.
Zhao C, MacKinnon R
Neuron (2022)
PMID: 36283409
Related structures: EMD-27343

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169297 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transient receptor potential cation channel, subfamily M, member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1370 amino acids
Theoretical weight: 157.68 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5F4S7 (Residues: 2-1371; Coverage: 80%)
Gene name: Trpm3
Sequence domains:
Unidentified segment at the N-terminus of TRPM3 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 17 amino acids
Theoretical weight: 1.46 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

4 bound ligands:
Ligand 3PH 4 x 3PH
Ligand 9Z9 4 x 9Z9
Ligand PIO 4 x PIO
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-27343
Expression system: Homo sapiens

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Citations

2 review citations

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases.
Zhang et al. (2023)
1 more