› 8cj3

X-ray diffraction
3Å resolution

Urea-based foldamer inhibitor c3u_7 chimera in complex with ASF1 histone chaperone

Released:
DOI: 10.2210/pdb8cj3/pdb
PDB entry 8cj3 coloured by chain, front view.
PDB entry 8cj3 coloured by chain, side view.
PDB entry 8cj3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unexpected binding modes of inhibitors to the histone chaperone ASF1 revealed by a foldamer scanning approach.
Perrin ME, Li B, Mbianda J, Bakail M, André C, Moal G, Legrand P, Ropars V, Douat C, Ochsenbein F, Guichard G
Chem Commun (Camb) (2023)
PMID: 37347155

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-220772 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone chaperone ASF1A Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y294 (Residues: 1-156; Coverage: 77%)
Gene names: ASF1A, CGI-98, HSPC146
Sequence domains: ASF1 like histone chaperone
c3u_7 chimera inhibitor of histone chaperone ASF1 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.38 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand ALN 1 x ALN

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P64
Unit cell:
a: 133.906Å b: 133.906Å c: 63.429Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.203 0.217
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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