› 8b9u

X-ray diffraction
2.25Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-220544 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ATP-dependent Clp protease ATP-binding subunit ClpC1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 144 amino acids
Theoretical weight: 15.84 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPC9 (Residues: 1-144; Coverage: 17%)
Gene names: MTCY07H7B.26, Rv3596c, clpC1
Sequence domains: Clp amino terminal domain, pathogenicity island component
(MLE)V(MAA)(E9M)G Chain: C
Molecule details ›
Chain: C
Length: 5 amino acids
Theoretical weight: 587 Da
Source organism: Nonomuraea sp. MJM5123
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand FMT 7 x FMT
3 modified residues:
Ligand MLE 1 x MLE
Ligand MAA 1 x MAA
Ligand E9M 1 x E9M

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P3221
Unit cell:
a: 57.44Å b: 57.44Å c: 174.49Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.212 0.249
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 citations in other articles

Proximity-inducing pharmacology.
Winter et al. (2024)