› 8azs

Electron Microscopy
2.9Å resolution

Type I amyloid-beta 42 filaments from high-spin supernatants of aqueous extracts from Alzheimer's disease brains | ABeta42

Released:
DOI: 10.2210/pdb8azs/pdb
PDB entry 8azs coloured by chain, front view.
PDB entry 8azs coloured by chain, side view.
PDB entry 8azs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains.
Stern AM, Yang Y, Jin S, Yamashita K, Meunier AL, Liu W, Cai Y, Ericsson M, Liu L, Goedert M, Scheres SHW, Selkoe DJ
Neuron (2023)
PMID: 37167969
Related structures: EMD-15770

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138402 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta protein 42 Chain: H
Molecule details ›
Chain: H
Length: 42 amino acids
Theoretical weight: 4.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05067 (Residues: 672-713; Coverage: 6%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-15770

Quick links

Citations

1 review citation

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids.
Scheres et al. (2023)
10 other articles