Function and Biology

CRYSTAL STRUCTURES OF ASPARTATE CARBAMOYLTRANSFERASE LIGATED WITH PHOSPHONOACETAMIDE, MALONATE, AND CTP OR ATP AT 2.8-ANGSTROMS RESOLUTION AND NEUTRAL P*H

Source organism: Escherichia coli
Biochemical function: protein binding
Biological process: 'de novo' pyrimidine nucleobase biosynthetic process
Cellular component: cytoplasm

EC 2.1.3.2: Aspartate carbamoyltransferase

Reaction catalysed:
Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate
Systematic name:
Carbamoyl-phosphate:L-aspartate carbamoyltransferase
Alternative Name(s):
  • ATCase
  • Aspartate carbamyltransferase
  • Aspartate transcarbamoylase
  • Aspartate transcarbamylase
  • Aspartic acid transcarbamoylase
  • Aspartic carbamyltransferase
  • Aspartic transcarbamylase
  • Carbamoylaspartotranskinase
  • Carbamylaspartotranskinase
  • L-aspartate transcarbamoylase
  • L-aspartate transcarbamylase

Sequence families

Pfam Protein families (Pfam)
PF01948
Domain description: Aspartate carbamoyltransferase regulatory chain, allosteric domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain

PF02729
Domain description: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit

PF00185
Domain description: Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit

PF02748
Domain description: Aspartate carbamoyltransferase regulatory chain, metal binding domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain

InterPro InterPro annotations
IPR006130
Domain description: Aspartate/ornithine carbamoyltransferase
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
IPR036901
Domain description: Aspartate/ornithine carbamoyltransferase superfamily
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
IPR002082
Domain description: Aspartate carbamoyltransferase
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
IPR036793
Domain description: Aspartate carbamoyltransferase regulatory subunit, N-terminal domain superfamily
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
IPR002801
Domain description: Aspartate transcarbamylase regulatory subunit
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
IPR006132
Domain description: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
IPR006131
Domain description: Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
IPR020542
Domain description: Aspartate carbamoyltransferase regulatory subunit, C-terminal
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
IPR036792
Domain description: Aspartate carbamoyltransferase regulatory subunit, C-terminal domain superfamily
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
IPR020545
Domain description: Aspartate carbamoyltransferase regulatory subunit, N-terminal
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain

Structure domains

CATH CATH domains
3.40.50.1370
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Aspartate/ornithine carbamoyltransferase
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
2.30.30.20
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: Aspartate carbamoyltransferase regulatory subunit, C-terminal domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
3.30.70.140
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Aspartate carbamoyltransferase regulatory subunit, N-terminal domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
SCOP SCOP annotations
53672
Class: Alpha and beta proteins (a/b)
Fold: ATC-like
Superfamily: Aspartate/ornithine carbamoyltransferase
Occurring in:
  1. Aspartate carbamoyltransferase catalytic subunit
54894
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain
57826
Class: Small proteins
Fold: Rubredoxin-like
Superfamily: Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain
Occurring in:
  1. Aspartate carbamoyltransferase regulatory chain