8api

X-ray diffraction
3.1Å resolution

THE S VARIANT OF HUMAN ALPHA1-ANTITRYPSIN, STRUCTURE AND IMPLICATIONS FOR FUNCTION AND METABOLISM

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 347 amino acids
Theoretical weight: 39.11 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01009 (Residues: 36-382; Coverage: 88%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Structure domains:
Short peptide from AAT Chain: B
Molecule details ›
Chain: B
Length: 36 amino acids
Theoretical weight: 4.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01009 (Residues: 383-418; Coverage: 9%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P6522
Unit cell:
a: 119.7Å b: 119.7Å c: 216.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.215 not available