8a66

X-ray diffraction
1.9Å resolution

Crystal structure of MST2 in complex with XMU-MP-1

Released:
Source organism: Homo sapiens
Entry authors: Nawrotek A, Vuillard L, Miallau L, Weber C

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 3 36kDa subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 298 amino acids
Theoretical weight: 33.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13188 (Residues: 16-312; Coverage: 61%)
Gene names: KRS1, MST2, STK3
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: C2221
Unit cell:
a: 90.77Å b: 99.04Å c: 167.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.258
Expression system: Escherichia coli