7znl

Electron Microscopy
3.45Å resolution

Structure of the human TREX core THO-UAP56 complex

Released:

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 28-mer (preferred)
PDBe Complex ID:
PDB-CPX-216401 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
THO complex subunit 1 Chains: A, I, a, i
Molecule details ›
Chains: A, I, a, i
Length: 657 amino acids
Theoretical weight: 75.75 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96FV9 (Residues: 1-657; Coverage: 100%)
Gene names: HPR1, THOC1
Sequence domains:
THO complex subunit 2 Chains: B, J, b, j
Molecule details ›
Chains: B, J, b, j
Length: 1593 amino acids
Theoretical weight: 183.09 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q8NI27 (Residues: 1-1593; Coverage: 100%)
Gene names: CXorf3, THOC2
Sequence domains:
THO complex subunit 3 Chains: C, K, c, k
Molecule details ›
Chains: C, K, c, k
Length: 351 amino acids
Theoretical weight: 38.82 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q96J01 (Residues: 1-351; Coverage: 100%)
Gene name: THOC3
Sequence domains:
THO complex subunit 5 Chains: E, M, e, m
Molecule details ›
Chains: E, M, e, m
Length: 683 amino acids
Theoretical weight: 78.62 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q13769 (Residues: 1-683; Coverage: 100%)
Gene names: C22orf19, KIAA0983, THOC5
Sequence domains: Fms-interacting protein/Thoc5
THO complex subunit 6 Chains: F, N, f, n
Molecule details ›
Chains: F, N, f, n
Length: 341 amino acids
Theoretical weight: 37.58 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q86W42 (Residues: 1-341; Coverage: 100%)
Gene names: PSEC0006, THOC6, WDR58
Sequence domains: WD domain, G-beta repeat
THO complex subunit 7 Chains: G, O, g, o
Molecule details ›
Chains: G, O, g, o
Length: 204 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q6I9Y2 (Residues: 1-204; Coverage: 100%)
Gene names: NIF3L1BP1, THOC7
Sequence domains: Tho complex subunit 7
Spliceosome RNA helicase DDX39B Chains: H, P, h, p
Molecule details ›
Chains: H, P, h, p
Length: 428 amino acids
Theoretical weight: 49.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13838 (Residues: 1-428; Coverage: 100%)
Gene names: BAT1, DDX39B, UAP56
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.45Å
Relevant EMDB volumes: EMD-14808
Expression systems:
  • Trichoplusia ni
  • Escherichia coli