7zbg

X-ray diffraction
2.3Å resolution

Human Topoisomerase II Beta ATPase ADP

Released:
Source organism: Homo sapiens
Entry authors: Ling EM, Basle A, Cowell IG, Blower TR, Austin CA

Function and Biology Details

Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA topoisomerase 2-beta Chain: A
Molecule details ›
Chain: A
Length: 400 amino acids
Theoretical weight: 45.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q02880 (Residues: 50-449; Coverage: 25%)
Gene name: TOP2B
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P321
Unit cell:
a: 103.4Å b: 103.4Å c: 67.02Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.197 0.259
Expression system: Escherichia coli BL21(DE3)