› 7yxg

X-ray diffraction
1.64Å resolution

Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and 2OG

Released:
DOI: 10.2210/pdb7yxg/pdb
PDB 7yxg coloured by chain and viewed from the front.
PDB 7yxg coloured by chain and viewed from the side.
PDB 7yxg coloured by chain and viewed from the top.
Source organism: Drosophila melanogaster
Primary publication:
Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans.
Chowdhury R, Abboud MI, Wiley J, Tumber A, Markolovic S, Schofield CJ
Sci Rep 12 6065 (2022)
PMID: 35410347

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
JmjC domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 322 amino acids
Theoretical weight: 36.7 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9VU77 (Residues: 1-316; Coverage: 100%)
Gene names: CG10133, Dmel\CG10133, Dmel_CG10133, JMJD7
Sequence domains: Cupin-like domain

Ligands and Environments

4 bound ligands:
Ligand MN 2 x MN
Ligand AKG 2 x AKG
Ligand EDO 9 x EDO
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 73.325Å b: 62.856Å c: 99.001Å
α: 90° β: 109.06° γ: 90°
R-values:
R R work R free
0.163 0.162 0.186
Expression system: Escherichia coli BL21(DE3)

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