7ywb

X-ray diffraction
1.92Å resolution

Crystal structure of YTHDF2 in complex with N6-Methyladenine

Released:
Source organism: Homo sapiens
Primary publication:
Fragment Ligands of the m6A-RNA Reader YTHDF2.
ACS Med Chem Lett 13 1500-1509 (2022)
PMID: 36110386

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
YTH domain-containing family protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 167 amino acids
Theoretical weight: 19.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5A9 (Residues: 408-552; Coverage: 25%)
Gene names: HGRG8, YTHDF2
Sequence domains: YT521-B-like domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P65
Unit cell:
a: 80.53Å b: 80.53Å c: 113.88Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.2 0.235
Expression system: Escherichia coli