› 7yis

X-ray diffraction
3.3Å resolution

Crystal structure of N-terminal PH domain of ARAP3 protein in complex with inositol 1,3,4,5-tetrakisphosphate

Released:
DOI: 10.2210/pdb7yis/pdb
PDB entry 7yis coloured by chain, front view.
PDB entry 7yis coloured by chain, side view.
PDB entry 7yis coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3.
Zhang Y, Ge L, Xu L, Liu Y, Wang J, Liu C, Zhao H, Xing L, Wang J, Wu B
Int J Mol Sci 24 (2023)
PMID: 36674645

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186757 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 13.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WWN8 (Residues: 284-385; Coverage: 7%)
Gene names: ARAP3, CENTD3
Sequence domains: PH domain

Ligands and Environments

1 bound ligand:
Ligand 4PT 1 x 4PT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P6122
Unit cell:
a: 74.154Å b: 74.154Å c: 109.85Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.224 0.276
Expression system: Escherichia coli

Quick links

Citations

1 mention without citation

Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3.
Zhang et al. (2023)