› 7yg0

Electron Microscopy
3.75Å resolution

Cryo-EM structure of human sodium-chloride cotransporter

Released:
DOI: 10.2210/pdb7yg0/pdb
PDB entry 7yg0 coloured by chain, front view.
PDB entry 7yg0 coloured by chain, side view.
PDB entry 7yg0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Nan J, Yuan Y, Yang X, Shan Z, Liu H, Wei F, Zhang W, Zhang Y
Sci Adv 8 eadd7176 (2022)
PMID: 36351028
Related structures: EMD-33803

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157149 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Solute carrier family 12 member 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1053 amino acids
Theoretical weight: 116.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55017 (Residues: 1-1021; Coverage: 100%)
Gene names: NCC, SLC12A3, TSC
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.75Å
Relevant EMDB volumes: EMD-33803
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Structural Pharmacology of Cation-Chloride Cotransporters.
Zhao et al. (2022)
3 more