› 7ws7

Electron Microscopy
3.4Å resolution

Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development

Released:
DOI: 10.2210/pdb7ws7/pdb
PDB entry 7ws7 coloured by chain, front view.
PDB entry 7ws7 coloured by chain, side view.
PDB entry 7ws7 coloured by chain, top view.
Source organisms:
Primary publication:
Structures of Omicron spike complexes and implications for neutralizing antibody development.
Guo H, Gao Y, Li T, Li T, Lu Y, Zheng L, Liu Y, Yang T, Luo F, Song S, Wang W, Yang X, Nguyen HC, Zhang H, Huang A, Jin A, Yang H, Rao Z, Ji X
Cell Rep 39 110770 (2022)
PMID: 35477022
Related structures: EMD-32749

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209996 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Spike protein S1 Chain: B
Molecule details ›
Chain: B
Length: 205 amino acids
Theoretical weight: 23.06 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 326-530; Coverage: 16%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding
510A5 light chain Chains: F, J
Molecule details ›
Chains: F, J
Length: 108 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
510A5 heavy chain Chains: G, K
Molecule details ›
Chains: G, K
Length: 125 amino acids
Theoretical weight: 13.74 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-32749
Expression system: Homo sapiens

Quick links

Citations

5 review citations

The nervous system during COVID-19: Caught in the crossfire.
Natale et al. (2022)
4 more

2 mentions without citation

Structures of Omicron spike complexes and implications for neutralizing antibody development.
Guo et al. (2022)
1 more