› 7wix

Electron Microscopy
3.53Å resolution

Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with ADP

Released:
DOI: 10.2210/pdb7wix/pdb
PDB entry 7wix coloured by chain, front view.
PDB entry 7wix coloured by chain, side view.
PDB entry 7wix coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Sun S, Gao Y, Yang X, Yang X, Hu T, Liang J, Xiong Z, Ran Y, Ren P, Bai F, Guddat LW, Yang H, Rao Z, Zhang B
Protein Cell 14 448-458 (2023)
PMID: 36882106
Related structures: EMD-32539

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162080 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mycobactin import ATP-binding/permease protein IrtA Chain: A
Molecule details ›
Chain: A
Length: 859 amino acids
Theoretical weight: 93.07 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: P9WQJ9 (Residues: 1-859; Coverage: 100%)
Gene names: MTCY02B10.12, Rv1348, irtA
Sequence domains:
Mycobactin import ATP-binding/permease protein IrtB Chain: B
Molecule details ›
Chain: B
Length: 579 amino acids
Theoretical weight: 61.01 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: P9WQJ7 (Residues: 1-579; Coverage: 100%)
Gene names: MTCY02B10.13, Rv1349, irtB
Sequence domains: ABC transporter

Ligands and Environments

2 bound ligands:
Ligand ADP 2 x ADP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.53Å
Relevant EMDB volumes: EMD-32539
Expression system: Mycolicibacterium smegmatis MC2 155

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