› 7wfw

Electron Microscopy
3.1Å resolution

Apo human Nav1.8

Released:
DOI: 10.2210/pdb7wfw/pdb
PDB entry 7wfw coloured by chain, front view.
PDB entry 7wfw coloured by chain, side view.
PDB entry 7wfw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8.
Huang X, Jin X, Huang G, Huang J, Wu T, Li Z, Chen J, Kong F, Pan X, Yan N
Proc Natl Acad Sci U S A 119 e2208211119 (2022)
PMID: 35858452
Related structures: EMD-32476

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195304 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Sodium channel protein type 10 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 1956 amino acids
Theoretical weight: 220.9 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y5Y9 (Residues: 1-1956; Coverage: 100%)
Gene name: SCN10A
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
5 bound ligands:
Ligand NAG 4 x NAG
Ligand CLR 4 x CLR
Ligand PCW 3 x PCW
Ligand LPE 8 x LPE
Ligand P5S 2 x P5S
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-32476
Expression system: Homo sapiens

Quick links

Citations

1 review citation

A structural atlas of druggable sites on Nav channels.
Li et al. (2024)
16 other articles