X-ray diffraction
2.3Å resolution

Co-crystal structure of FTO bound to 6e


Function and Biology Details

Reaction catalysed:
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Alpha-ketoglutarate-dependent dioxygenase FTO Chain: A
Molecule details ›
Chain: A
Length: 491 amino acids
Theoretical weight: 56.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9C0B1 (Residues: 32-505; Coverage: 94%)
  • Best match: Q9C0B1-4 (Residues: 1-106)
Gene names: FTO, KIAA1752
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: R3
Unit cell:
a: 141.759Å b: 141.759Å c: 83.74Å
α: 90° β: 90° γ: 120°
R R work R free
0.204 0.202 0.241
Expression system: Escherichia coli