7vpp

X-ray diffraction
2.69Å resolution

Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans

Released:
Entry authors: Ji W, Xu Y, Zhang S

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Aminopeptidase Chains: A, C
Molecule details ›
Chains: A, C
Length: 911 amino acids
Theoretical weight: 103.8 KDa
Source organism: Sus scrofa
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: K7GMF9 (Residues: 58-961; Coverage: 94%)
Gene names: ANPEP, pAPN
Sequence domains:
Spike protein Chain: B
Molecule details ›
Chain: B
Length: 127 amino acids
Theoretical weight: 14.33 KDa
Source organism: Porcine deltacoronavirus
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: A0A4P8D758 (Residues: 299-418; Coverage: 10%)

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL02U1
Spacegroup: P41212
Unit cell:
a: 186.643Å b: 186.643Å c: 173.823Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.23
Expression system: Baculovirus expression vector pFastBac1-HM