7v3g

Electron Microscopy
3.3Å resolution

DENV2_NGC_Fab_C10 28degrees (2Fab:3E)

Released:

Function and Biology Details

Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero 600-mer (preferred)
PDBe Complex ID:
PDB-CPX-210586 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (5 distinct):
Envelope protein E Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 495 amino acids
Theoretical weight: 54.36 KDa
Source organism: Dengue virus 2 Thailand/NGS-C/1944
Expression system: Aedes albopictus C6/36 cell densovirus
UniProt:
  • Canonical: P14340 (Residues: 281-775; Coverage: 15%)
Sequence domains:
Small envelope protein M Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 72 amino acids
Theoretical weight: 8.03 KDa
Source organism: Dengue virus 2 Thailand/NGS-C/1944
Expression system: Aedes albopictus C6/36 cell densovirus
UniProt:
  • Canonical: P14340 (Residues: 206-277; Coverage: 2%)
Sequence domains: Flavivirus envelope glycoprotein M
Fab_C10_light_chain Chains: G, I
Molecule details ›
Chains: G, I
Length: 127 amino acids
Theoretical weight: 14.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fab_C10_heavy_chain Chains: H, M
Molecule details ›
Chains: H, M
Length: 109 amino acids
Theoretical weight: 11.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-31678
Expression systems:
  • Aedes albopictus C6/36 cell densovirus
  • Homo sapiens