X-ray diffraction
3.27Å resolution

Crystal structure of the macro-oligomeric form of DNMT3B methyltransferase domain.

Source organism: Homo sapiens
Entry authors: Gao L, Lu J, Song J

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
DNA (cytosine-5)-methyltransferase 3B Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 285 amino acids
Theoretical weight: 32.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9UBC3 (Residues: 569-853; Coverage: 33%)
Gene name: DNMT3B
Sequence domains: C-5 cytosine-specific DNA methylase

Ligands and Environments

Cofactor: Ligand SAH 8 x SAH
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P32
Unit cell:
a: 164.393Å b: 164.393Å c: 209.175Å
α: 90° β: 90° γ: 120°
R R work R free
0.206 0.206 0.235
Expression system: Escherichia coli