› 7uz9

Electron Microscopy
3.5Å resolution

Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-34

Released:
DOI: 10.2210/pdb7uz9/pdb
PDB entry 7uz9 coloured by chain, front view.
PDB entry 7uz9 coloured by chain, side view.
PDB entry 7uz9 coloured by chain, top view.
Source organisms:
Primary publication:
Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022)
PMID: 36370711
Related structures: EMD-26883

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-225379 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1256 amino acids
Theoretical weight: 139.34 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1213; Coverage: 95%)
Gene names: 2, S
Sequence domains:
M8a-34 Fab heavy chain Chains: H, M, P
Molecule details ›
Chains: H, M, P
Length: 235 amino acids
Theoretical weight: 25.51 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
M8a-34 Fab light chain Chains: L, N, Q
Molecule details ›
Chains: L, N, Q
Length: 218 amino acids
Theoretical weight: 23.96 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
Ligand NAG 42 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.5Å
Relevant EMDB volumes: EMD-26883
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Bringing immunofocusing into focus.
Musunuri et al. (2024)
3 more

1 mention without citation

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.
Fan et al. (2022)