› 7uxn

X-ray diffraction
1.36Å resolution

Structure of PPIA in complex with FP29103, a Helicon Polypeptide

Released:
DOI: 10.2210/pdb7uxn/pdb
PDB entry 7uxn coloured by chain, front view.
PDB entry 7uxn coloured by chain, side view.
PDB entry 7uxn coloured by chain, top view.
Source organisms:
Primary publication:
De novo mapping of α-helix recognition sites on protein surfaces using unbiased libraries.
Li K, Tokareva OS, Thomson TM, Wahl SCT, Travaline TL, Ramirez JD, Choudary SK, Agarwal S, Walkup WG, Olsen TJ, Brennan MJ, Verdine GL, McGee JH
Proc Natl Acad Sci U S A 119 e2210435119 (2022)
PMID: 36534810

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158798 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase A Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 18.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
FP29103 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.34 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand WHL 1 x WHL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 42.08Å b: 48.01Å c: 81.87Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.217
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

Dystrophin- and Utrophin-Based Therapeutic Approaches for Treatment of Duchenne Muscular Dystrophy: A Comparative Review.
Szwec et al. (2023)
4 other articles