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› 7udw

X-ray diffraction
3Å resolution

Designed pentameric proton channel QQLL

Released:
DOI: 10.2210/pdb7udw/pdb
PDB entry 7udw coloured by chain, front view.
PDB entry 7udw coloured by chain, side view.
PDB entry 7udw coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Transient water wires mediate selective proton transport in designed channel proteins.
Kratochvil HT, Watkins LC, Mravic M, Thomaston JL, Nicoludis JM, Somberg NH, Liu L, Hong M, Voth GA, DeGrado WF
Nat Chem (2023)
PMID: 37308712

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-168918 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
De novo designed pentameric proton channel QQLL Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T
Length: 26 amino acids
Theoretical weight: 3.06 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 48.246Å b: 100.175Å c: 50.498Å
α: 90° β: 110.506° γ: 90°
R-values:
R R work R free
0.255 0.251 0.286
Expression system: Not provided

Quick links

Citations

1 citations in other articles

Atomic structure of the open SARS-CoV-2 E viroporin.
Medeiros-Silva et al. (2023)

1 mention without citation

Transient water wires mediate selective proton transport in designed channel proteins.
Kratochvil et al. (2023)